General tests, such as biochemistry and a clinical blood test, are known to every patient who, at least once in a lifetime, undergoes a medical examination. However, diagnostic tools allow you to explore a wide range of parameters in order to get maximum information about the patient’s health status. What is this P-LCR in a blood test? This is one of the types of platelet research, blood cells that are responsible for blood clotting.
Parameters for research
Medical examination begins with general tests. In the presence of anxiety symptoms and complaints from the patient, the standard test expands. In addition to the total number of cells, the laboratory can assess their condition, size, mobility, maturity, and other factors. So, with a normal general level of platelets, the number of large cells can be increased, which means a violation of some processes in the body.
The study is conducted in laboratory conditions. A general clinical analysis may not imply a test for P-LCR (Large Platelet Ratio). This and other parameters for analysis are indicated in the direction at the discretion of the physician. P-LCR reflects the proportion of enlarged platelets relative to normal-sized cells, a measure measured as a percentage. The LCC or fraction of large platelets is essentially the same indicator as P-LCR, but is measured in absolute terms.
During illness or development of the pathology, any of these indicators may be lowered or increased. Changes in the quantity and quality of blood cells, as well as their functions, are displayed by a clinical blood test. To determine the possible violations of the interpretation of the test results. Interpretation of the data obtained is carried out by a qualified specialist, taking into account all factors that could affect the results of the study.
The normal level of P-LCR for all categories of patients is 13-43%. In some cases, if there is a chronic disease or congenital abnormality, an amendment is made to the patient’s condition. The doctor may consider such cases as individual and the treatment may also differ. The generally accepted value of total platelet levels varies with the age of the patient.
- The rate of total platelet count for women and men is 180–320 × 10 9 / l.
- Newborn babies have unstable rates in many ways; platelet counts can vary from 180 to 490 × 10 9 / l. Within a few days the level is stabilized.
- In children in the first year of life, the norm is within 180–400 × 10 9 / l.
- At the age of 1–6 years, the rate of platelet concentration is 160–390 × 10 9 / l.
- In children aged 7 to 12 years, this figure is 16-380 × 10 9 / l.
- In adolescence of 13–15 years, the rate of platelets is 160–360 × 10 9 / l, gradually the indicator approaches the “adult” value.
Exceeding the permissible limit of the norm means that the number of large-sized blood cells has increased. Explanation of the blood test includes not only checking the obtained data for compliance with the norm, but also the individual characteristics of the body, the presence of chronic diseases, etc. Also, the fact that different laboratories use different equipment and reagents should be taken into account. The result even depends on the supplier of the chemicals and the concentration of the solution. Therefore, the results of blood tests of one patient in two laboratories may differ. The permissible rate is indicated on the result form next to the patient indicator.
If the level of platelets is elevated, problems with blood flow occur and the movement of cells through the veins and arteries is hampered. An increase in platelet count is known as thrombocytosis and this condition can be very dangerous for the patient. Due to its unique properties of gluing together, platelets prevent the formation of bleeding. The cells are attached to each other, forming a blood clot, and cover up cuts, scratches and other tissue damage.
If the overall platelet count or P-LCR is high, there is a risk of spontaneous blood clot formation.
Thus, certain parts of the circulatory system can be blocked, and the access of oxygen to certain organs will become limited. The situation is aggravated by high cholesterol or vasoconstriction. Veins and arteries can overlap with cholesterol plaques, which creates additional barriers to the movement of cells through the bloodstream.
The cause of this condition may be a malfunction of the bone marrow, which disrupts the formation of blood cells. For example, leukemia, leukemia, metastasis of cancer, penetrated into the bone marrow. Also, an increase in P-LCR of platelets can be caused by viral infections and the toxic effects of toxic substances (poisons, chemicals, etc.).
When P-LCR is elevated, the patient displays the physical symptoms of such a condition. In most cases, they can not be noticed for the obvious symptoms of the underlying disease. In the treatment of the disease in the hospital under the supervision of the attending physician, the blood for the study is taken regularly. At the same time miss the moment when the level of platelets or P-LCR will begin to increase impossible. But the patient himself can determine the state in which the platelet cells increase in size by the following symptoms.
- High sensitivity of the fingers, especially the tips, up to the pain.
- The appearance of bruises and subcutaneous hemorrhages for no apparent reason.
- Bluish skin and itchy sensation.
- General weakness of the body, lethargy, reduced working capacity.
- Reduced vision.
- Frequent nasal, intestinal bleeding, in women abundant periods.
The manifestation of all the symptoms of high P-LCR at once is extremely unlikely. As a rule, patients notice the appearance of 2-3 signs, which is a reason to consult a doctor and pass the appropriate tests. The sooner the cause of the disease is identified, the higher the chances for a quick and successful recovery.
To normalize the level of platelets and their size, the first treatment is directed to the primary disease. After the elimination of inflammation (pneumonia, hepatitis, parasitic inflammation, etc.), the P-LCR index gradually normalizes. In severe cases, with significant abnormalities, the doctor prescribes medication for thrombocytosis. The process is fully controlled, and the effectiveness of treatment is monitored by regular blood tests. The following drugs are used for exposure: Interferon, Alkeran, Anagrelid, etc.
Minor deviations from the norm do not threaten the patient’s life. The safest and most gentle treatment in this case is diet. It is recommended to include in the diet more foods that can thin the blood. Especially useful garlic and onions in fresh form. Platelets reduce tomatoes and fresh juice from them, dressings for salads with apple cider vinegar, fish oil, olive oil. You must also include in the diet foods rich in magnesium and drink enough fluids, at least 2 liters per day. Excluded from the use of products that thicken the blood.
Reduced P-LCR or total platelet count (thrombocytopenia) is associated with the development of some serious diseases. Chronic nephritis and other kidney inflammation, malaria, leukemia. Greatly reduces the number of platelets by radiation and chemotherapy, as well as poisoning by salts of heavy metals.
Treatment of thrombocytopenia is carried out only after establishing the exact cause of the violation. Therapeutic actions are directed to the elimination of the underlying disease. If there are significant deviations from the norm, the doctor prescribes medication that thickens the blood. Also, herbal tinctures and nutritional adjustments have a rather high efficacy in mild cases of thrombocytopenia. It is recommended to include dogrose broth, walnuts, boiled beef, lentils, etc. in the daily diet. Blood thinning products are excluded.
With a detailed study of the results of the analysis, decoding gives the attending physician a maximum of information. The patient receives an answer to the question what is this P-LCR in the blood test. Among other indicators, data on platelets in human blood can draw attention to a problem in time. Modern methods of treatment can eliminate thrombocytosis and thrombocytopenia and prevent negative consequences.