Apigenin is a widely found plant flavone in nature. It is abundantly present in some fruits and vegetables, recognized as a bioactive flavonoid, which has anti-inflammatory, antioxidant and anti-tumor properties.
Flavones are a subclass of flavonoids. Epidemiological studies show that eating foods rich in flavones reduces the risk of developing certain types of cancer, in particular breast cancer, the digestive tract, skin, prostate gland and some hematological malignancies.
It has been suggested that apigenin may also act as a defense mechanism in other diseases, especially those associated with the oxidative process, such as cardiovascular and neurological disorders, although more research is needed for accurate evidence.
Clinical trials on humans studying the effect of apigenin supplementation for the prevention of disease have not been conducted. But there is a significant potential for using apigenin as a chemotherapy drug for treating cancer.
From this article you will learn:
The powerful strength of flavonoids
Flavonoids are a family of polyphenolic compounds synthesized from plants with a similar structure. They are divided into subclasses, including anthocyanins, flavanols, flavonols, flavones and isoflavones.
These plant compounds are prescribed several beneficial properties, including antioxidant, anti-inflammatory and anti-carcinogenic.
According to the estimate, the average use of flavonoids in the form of flavonols and flavones varies from 6 mg / day in Finland to 64 mg / day in Japan, with intermediate results in other countries: USA (13 mg / day), Italy (27 mg / day), Netherlands (33 mg / day), Holland (23 mg / day), Denmark (28 mg / day), Finland (55 mg / day). This assessment is based on an analysis of five plant flavonoids: quercetin, kaempferol, myricetin, luteolin and apigenin in the food samples of the population analyzed in the Seven Countries study.
The use of five flavonoids was evaluated from 17 different diets. The lowest doses (1–9 mg / day) are attributed to the South African diet, while the highest use of flavonoids (75–81 mg / day) in Scandinavian diets.
Dietary sources of flavonols and flavones vary in different countries: tea in Japan (95%) and the Netherlands (64%), red wine and beer in Italy (46%), vegetables and fruits in Finland (100%) and the USA (80%) . In Australia, tea remains the main dietary flavonoid with an approximate consumption of up to 351 mg / person / day, of which 75% are flavan-3-ol.
One such substance that has acquired considerable interest as a beneficial agent for human health with prophylactic and therapeutic properties against cancer is flavone apigenin.
What is apigenin?
Apigenin is a naturally occurring color compound found in many fruits and vegetables, such as parsley, onions, oranges, tea, chamomile, grapefruit, wheat seedlings and some seasonings.
Yellow crystals of apigenin are commonly used for dyeing clothes. Its useful properties have been thoroughly studied in animals, but the effect on humans is not fully known.
Apigenin has one incredible characteristic: the ability to fight the effects of carcinogens, to prevent and eliminate various types of cancer in the body.
Apigenin is chemically known as 4, 5, 7, – trihydroxyflavone with the molecular formula C15H10O5, the molecular weight of which is MW