Depression Medication Weight Loss

Ethosuximide is a medicinal antiepileptic drug, it belongs to the group of succinimides, it is especially effective in the treatment of absences that are not accompanied by other types of seizures. This tool is included in the list of essential medicines according to WHO.

The most popular agents based on Ethosuximide are Suksilep, Petnidan and Zarontin, all medicines have a similar mechanism of action on the body, almost identical indications and side effects.

The composition of all drugs include the active substance ethosuximide, as well as impurity components, including macrogol, E110, titanium dioxide, gelatin, water, and others.

Medicines are available in the form of syrup, drops and capsules.

Pharmacological properties

Ethosuximide inhibits synaptic transmission in some areas of the brain, thereby reducing seizure activity and the number of seizures in a patient. Perform as an analgesic for neuralgia and some other neurological diseases.

The active substance is absorbed almost completely. The effective plasma concentration is 40-100 µg / ml. At a concentration of more than 150 µg / ml, toxic reactions may occur.

The state of "equilibrium" occurs after 8-10 days after the start of taking capsules. The liver processes the active component into monomers, which are eliminated by the kidneys. 10-20% are displayed unchanged.

Depression Medication Weight Loss

Brief description of analogs

Petnidan is a drug based on ethosuximide of a famous German pharmaceutical company that guarantees the effectiveness and quality of its drugs. It is one of the main antiepileptic drugs prescribed mainly for children. It is used in many types of juvenile and pediatric epilepsy. It can be used as an additional therapy.

The drug is introduced into the course of treatment gradually, with the constant monitoring of the patient’s condition. Petnidan has multiple side effects, namely: nausea, dizziness, migraine, abdominal pain, weight loss, diarrhea, unstable emotional state, and allergic reactions to the drug may occur.

Zarontin is an antiepileptic drug, which is prescribed for the treatment of epilepsy, ternary neuralgia and for the relief of many types of convulsive seizures. It has a more impressive list of side effects than other drugs based on ethosuximide.

Suksilep – the most effective drug among analogues on the basis of ethosuximide. Prescribed in the treatment of epilepsy and for the relief of various types of seizures. The drug has the same list of side effects. Consider its characteristics in more detail.

Scope of application and contraindications

Suxilep is indicated for administration when:

Do not take medicine:

  • in the event that the child is under six years old;
  • during lactation;
  • if the patient is diagnosed hypersensitive to the active substance;
  • with mental illness;
  • with renal or hepatic failure.

Recommended dosages

The drug should be taken before or during meals, you need to drink plenty of water capsules. The attending physician selects the dosage for each patient exclusively individually, based on the overall picture of the disease and the characteristics of the patient.

Therapy begins with small doses of ethosuximide, with time the dosage increases.

The daily dose is calculated in direct proportion to the weight of the patient. For children from 12 years and adults:

  • up to 50 kg – from 750 to 1500 mg;
  • from 67 kg – from 1000 to 2000 mg;
  • from 83 kg – from 1250 to 2500 mg.

For children under twelve:

  • up to 13 kg – from 250 to 500 mg;
  • from 25 kg – from 500 to 1000 mg;
  • from 38 kg – from 750 to 1500 mg;
  • from 50 kg – from 1000 to 2000 mg.

The treatment period is usually long. The duration of the course can only be determined by the attending physician. The dose should be reduced only if the convulsive seizures do not appear for several years.

Cancel the drug gradually. This process usually takes one or two years, depending on the condition of the patient.

Adverse reactions

When taking the drug should be careful with the dosage, since when it is exceeded, there may be many side effects:

The most common adverse reactions are nausea and vomiting.

This drug has a rather wide list of side effects, but they are quite rare. If you follow a special diet, do not drink alcohol and monitor the level of drug concentration in the blood plasma, then the danger is over.

What to do with overdose?

Overdose is diagnosed in the case when the concentration of the active substance in the blood is more than 150 µg / ml.

Symptoms of intoxication include lethargy, depression, and the side effects listed above.

In case of intoxication, it is necessary to immediately clear the stomach by taking a couple of tablets of activated charcoal. The patient, as a rule, is sent to intensive care for procedures for cleansing the cardiovascular and respiratory systems of the body.

Special patients

If the expectant mother will take Suksilep during pregnancy, then there is a chance of detecting malformations in the child. Constant monitoring of the state of the mother’s body is necessary.

If there is an urgent need, the medication should be administered in individual doses for the patient on certain days of pregnancy. The safest period of drug use during pregnancy is the period between the twentieth and the fortieth day.

If pregnancy occurs, you should immediately consult with your doctor.

Ethosuximide is excreted with milk, so breastfeeding is not acceptable.

Reception at children’s age

Drugs based on ethosuximide are just intended for children. But there is an age limit, only from six years old a child can start taking these medications. Dosing is determined by the attending physician.

special instructions

At the time of therapy, it is necessary to abandon alcohol, as this may lead to undesirable consequences for the patient.

Depression Medication Weight Loss

In case of kidney or liver failure, medication is not recommended. The active substance is derived from the work of the kidneys and liver. If the organs do not cope, then a certain percentage of the substance will remain in the blood plasma. Excessive accumulation of funds is fraught with overdose.

An individual course of therapy is being developed for these patients. Dosing is determined by the attending physician.

Ethosuximide does not cause a change in the concentration of other drugs in the patient’s blood. Sometimes Phenytoin level rises.

Carbamazepine and valproic acid may affect the concentration of the active substance.

If you take with Suksilep drugs that affect the work of the central nervous system, then their sedative properties increase.

Opinion of patients

Reviews of patients who took Suksilep and its analogues on the basis of ethosuximide for the relief of various types of seizures.

For several years we have been using Suksilep as an active therapy. They took medicine for a while and became very irritable. The medicine has a terrible taste, can cause irritation of the stomach and vomiting. I add means in mashed potatoes and porridges.

Nina, mother of Alyosha

He has a nasty taste, so the child often had vomiting. No more side effects were reported. They found out about the imported analogue Petnidan, which is sold in the form of syrup and drops. Syrup is well drunk, but this medicine did not suit us.


He helped us. Still, it tastes pretty unpleasant, so much so that the child has vomiting. It is necessary to drink plenty of clean water. To avoid nausea, consumed half a capsule with a meal.

Katerina Leonidovna, 48

For four years we have been registered with a doctor with a diagnosis of epilepsy. Relatively recently switched to Suksilep. It is much more effective than those drugs that we used before.

Attacks became much less, and it is noticeable. During the application of the drug, they found only one problem, unbearable taste. The taste is very sharp, the child sometimes can not stand it, it nauseates and vomits. Extremely unpleasant moment.

To prevent this from happening, she began giving out half a capsule each time before eating. I put part of the capsule in the porridge and mashed potatoes, the child eats and does not feel this nasty taste.

Alena, 27

Conclusions from the words of experienced …

This is a very effective antiepileptic remedy that helps to deal with seizures. The drug is terrible to taste, many patients can not take it, because immediately comes vomiting.

Drugs based on ethosuximide are often recommended by doctors. Most patients who took the drug had no side effects other than vomiting and abdominal pain.

Purchase and storage

The average price of Suksilep at the moment – 7350 rubles. The cost can vary in the range of 1000-2000 rubles. Shelf life of the drug is 3 years.


Other analogues

In addition to popular products based on ethosuximide, such as Suksilep, Petnidam and Zarontin, there are less popular counterparts in their effects on the body, namely:

Any replacement of drugs with each other should consult a doctor.

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