Pregnancy hypotonia


Composition and release form:

Injection. Ampoules 2 ml number 6

Thiokolchicoside. 4 mg

Pharmacological properties:

Pharmacodynamics. Muscomed contains the active ingredient thiocolchicoside, a semisynthetic muscle relaxant, which is derived from the natural glycoside of colchicoside. It exhibits selective affinity for gamma-aminobutyric acid (GABA) and glycine receptors, which determines the effect of the drug at different levels of the nervous system, both with spasms of a local nature and with spasms of central origin. Muscomed does not have a curare-like action, does not cause paralysis and does not affect the cardiovascular and respiratory systems.

Pharmacokinetics. When administered intramuscularly, thiocolchicoside is rapidly distributed in the blood, the peak concentration in plasma is reached in 15-45 minutes. After a single intramuscular injection of 4 mg thiocolchicoside, the maximum plasma concentration is 61 ng / ml. Protein binding (mainly albumin) is 13%. The average imaginary volume of distribution is 76 liters after a single intramuscular injection at a dose of 4 mg. The half-life is 2.5-5 hours. Approximately 20% of the dose taken is excreted in the urine as unchanged metabolites, 75-81% is excreted in the feces.

For additional short-term relief of painful muscle contractures.


Muscomed is administered intramuscularly in a dose of 2 ml (4 mg) 2 times a day.

Pregnancy hypotonia

The recommended duration of treatment with an injectable form of the drug is 3-5 days. If necessary, continue treatment with oral forms of the drug for 5-7 days in a total daily dose of 16 mg of thiocolchicoside (8 mg twice a day). In preparation for physiotherapeutic procedures, the period of muscle relaxation is 30-40 minutes after intramuscular injection.

Children. The drug is contraindicated in children under the age of 16 years.

Contraindications: A

  • hypersensitivity to the drug;
  • muscle hypotension;
  • mild paralysis

Side effects:

Rarely: skin rash, edema, allergic and pseudo-allergic reactions (allergic vasculitis), pain in the stomach, diarrhea. Very rarely: hypotension, irritability and drowsiness.

Special instructions:

Muscomed should be used with caution in case of impaired kidney or liver function. With caution it is necessary to use the drug in patients with epilepsy or the risk of seizures.

Use during pregnancy or lactation. Muscomed is contraindicated during pregnancy and lactation.

The ability to influence the reaction rate when driving vehicles or other mechanisms. During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require an increased concentration of attention and speed of psychomotor reactions.


There is no data on drug interactions. However, caution is advised when taken with other muscle relaxants at the same time. With simultaneous use with drugs that suppress the central nervous system (CNS), including alcohol, antihypertensive drugs, curariform drugs, possible increased muscle relaxation and depression of the central nervous system, the development of hypotension. With simultaneous use with anticoagulants increases the risk of bleeding.


No overdose data.

Symptoms: possible increased adverse reactions.

Treatment: symptomatic, supportive therapy.

Pregnancy hypotonia

Storage conditions:

Store at a temperature not exceeding 25 ° C in the reach of children.

Pregnancy hypotonia

Registration data:

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