Protargol (silver proteinate) is a colloidal solution of silver, which is produced and used as an aqueous colloidal solution, and has a astringent, anti-inflammatory and pronounced antiseptic effect. It is a powder (dry extract) containing 7.8–8.3% silver, from which in the production departments of the pharmacy prepare one and / or two percent aqueous solution, which is used in the form of nasal drops, eye drops and solutions for washes Bladder. This drug is actively used in the treatment of inflammatory processes occurring in ophthalmology, urology, otolaryngology and is prescribed for the treatment of inflammatory processes, including purulent – rhinitis, conjunctivitis, adenoiditis, pharyngitis, urethritis. The main positive qualities of Protargol are the absence of dysbiotic disorders of the intestinal microflora (intestinal dysbiosis) and the absence of addiction. It is effective for the treatment of complicated rhinitis of various etiologies – with protracted purulent rhinitis, sinusitis, ethmoiditis and frontal sinusitis, for the treatment of recurrent and protracted nasopharyngitis and pharyngitis, as well as for the treatment of adenoiditis and purulent inflammatory processes of the middle ear. With predominantly purulent or complicated inflammation of the mucous membrane of the eyes (conjunctiva), as well as with the treatment of inflammatory diseases of the urinary tract (cystitis and urethritis). And to prevent the development of blepharitis in newborns.
Pharmacological properties of protargol and mechanism of action
The basis of the mechanism of action of protargol on the damaged, as a result of the inflammatory process of the mucous membranes or the skin surface is the formation of a protective film that occurs due to silver deposition of proteins, reducing the sensitivity of the mucous membranes, and activating vasoconstriction, which leads to inhibition of inflammatory reactions. Silver ions also have the ability to inhibit the reproduction of various bacteria, fungal flora and, to a lesser extent, viruses. At a lower percentage, the colloidal solution of protargol has a bacteriostatic effect, and at a higher concentration, it has a bactericidal effect on the bacterial and fungal pathogenic flora.
Indications for use
Aqueous colloidal solution of protargol is used for the treatment of rhinitis of various etiologies (rhinitis, sinusitis, ethmoiditis, frontitis), for inflammation of the mucous membrane of the eyes (conjunctivitis), for the treatment of pharyngitis and nasopharyngitis, for the treatment of adenoiditis and inflammatory processes of the middle ear (otitis), for the treatment of inflammatory diseases of the urethra (cystitis and urethritis). And also to prevent the development of blepharitis in newborns.
Protargol release form
The drug Protargol is available in the form of 1% and 2% aqueous colloidal solution for local use.
This is one of the few medicines on the modern pharmaceutical market that needs to be used only fresh, ordering a solution in a pharmacy, and when the expiration date has expired, acquire a new solution of the desired concentration. This is due to the fact that the unique properties of silver ions, which are contained in the colloidal solution of Protargol, provide its effective antiseptic effect, but it is very difficult to obtain active metal ions, because silver quickly turns into a bound state. But it is this quality that is used in the manufacture of dry extract. Silver is first associated with a protein substrate, which is then dried. The colloidal solution, which was previously actively used in medical practice and has not lost its relevance today, is obtained from dry extract, which is dissolved in distilled water. As a result of the dissociation reaction, silver ions pass into the active state from protein complexes into water and due to which they easily penetrate into the bacterial and fungal cells, disrupting the processes of its vital activity.
Protargol solution is manufactured in the production department of the pharmacy, which manufactures medicinal solutions from medicinal raw materials. In a small village, usually pharmacies do not have their own manufacturing department engaged in the manufacture of medicines, you will have to look for a nearby city and go for the drug to where it can be prepared. The pharmacist prepares the drops in the pharmacy by simply mixing the dry extract with distilled water, and the preparation process itself does not take much time. But to get dry extract and independently dilute it will not work, due to the fact that it is necessary to adhere to the method of preparation and accurate weighing of all the necessary ingredients. Order and purchase Protargol can only by prescription.
Also, before starting to use Protargol, it is necessary to know that it is a very effective, but not entirely innocuous drug, which has side effects and contraindications, as well as exact compliance with the recommendations of the attending physician – the dose, concentration, dose rate during the day and the duration of use for various pathological conditions in children and adults.
This drug is intended for local use only.
In the treatment of inflammatory diseases of the eye, Protargol is prescribed in the form of a 1% or 2% solution: for adults and children, two or three drops about two to four times a day by eye instillation.
For the treatment of urological infections (cystitis and urethritis) used 2% colloidal solution of the drug Protargol, which is used for washing the urethra and bladder.
For the treatment of otolaryngological diseases (rhinitis, pharyngitis, otitis), adults and children with 1% or 2% solution of Protargol should be prescribed three to five drops twice a day, instilled into each nostril.
Special recommendations for the use of the drug in the form of a colloidal aqueous solution are – thorough washing of the nose (especially in childhood) before dropping the drug. After holding the toilet of the nose, the baby should be put on his back and instilled the amount of drops prescribed by the doctor in each nasal passage, adhering to the frequency of use during the day. The instillation of Protargol is carried out in the morning and in the evening, and the effect of this drug appears in two or three days. The duration of treatment with Protargol is determined by the attending physician.
Side Effects of Protargol
It should be noted that this drug, like any other drug can cause a number of side effects, especially if used in inadequate dosage or long-term and uncontrolled. These include: allergic reactions – irritation of the mucous membrane, itchy skin, urticaria, atopic dermatitis, eye redness, angioedema, or anaphylactic shock. There may also be: dry mouth, numbness or burning sensation, headache, drowsiness or dizziness.
The use of the drug Protargol is strictly contraindicated for pregnant women and when breast-feeding a child, as well as in the presence of increased individual sensitivity to the drug or its components (in particular, to silver and its protein components).
This fact is the main reason for the significant restriction of the use of this fairly effective drug and the need for careful collection of allergic anamnesis. Therefore, adults and children with a high propensity for allergic reactions or with adverse family allergies, as well as reduced immunity Protargol is used only under the supervision of a physician. In childhood, Protargol is used only in 1% colloidal solution.
Also, parents of young children should be aware of the high toxicity of the drug when taken orally. Children up to three or four years old have an incredible curiosity and an almost complete lack of a sense of self-preservation and personal safety, so there are often enough cases when a young child consumes a large amount of the drug by mouth. When using Protargol, this can lead to severe poisoning and even death. In addition, it must be remembered that silver is a heavy metal having a certain hazard class and level of permissible concentration. Like most heavy metals, silver with a steady flow can accumulate and is slowly eliminated from the body. And getting into the gastrointestinal tract, this chemical element, due to its physicochemical properties, easily penetrates into the bloodstream and is spread throughout the body. Silver can be deposited in the skin and mucous membranes, in the kidneys, bone marrow, spleen, capillary walls, cornea and lens of the eye and endocrine glands. The accumulation of silver in the human body causes a specific disease called "argyrosis". Therefore, if there is a small child in the family, you must always monitor the amount of the drug and keep it out of the reach of children.
Protargol for children
Since ancient times, the healing properties of silver have been used by people for the treatment and prevention of many diseases. Therefore, many parents who note the effectiveness of Protargol solution, sometimes without thinking, use it at the first need – a slight cold, coughing or the onset of a viral infection. And this is not correct. Only a doctor should prescribe this drug, and it can only be used freshly prepared in a pharmacy.
Treatment with Protargol should be carried out with a full understanding of the benefits and risks of using this drug.
At present, when choosing an effective drug for children, especially when treating prolonged inflammatory processes in the nasal cavity and its paranasal sinuses (rhinitis or sinusitis), parents are guided by the opinion of a trusted pediatrician or pediatric otolaryngologist. To date, there are a number of modern products – sprays and drops, which are determined by their manufacturers as completely safe and at the same time no less effective drugs than drops in Protargol’s nose. But practitioners who have the opportunity to realistically evaluate all the positive qualities of this drug, and are well acquainted with all its side effects – prescribe it in their medical practice quite often, because it copes with its task immaculately and quickly. Possessing a range of positive effects – astringent, anti-inflammatory and pronounced antiseptic action, Protargol when applied strictly according to the instructions! – according to the prescribed dosage, solution concentration, frequency of use, duration and at the appropriate timeline for implementation is the most effective tool in the treatment of purulent inflammation of the nasal cavity, nasopharynx, eye mucosa or in severe purulent infections of the urinary system in children. The use of this drug in newborns allows you to avoid infection of the eyelids and a very frequent postpartum complication – the development of blepharitis in newborns. At the same time, Protargol, as a highly effective drug, quickly destroys any bacteria – gram-negative and gram-positive, aerobic and anaerobic, while addiction is not formed to it, and it does not cause intestinal dysbiosis.
Therefore, with good individual tolerance of silver and its protein fractions, which are used in this preparation to bind its ions in the preparation of dry extract, it is necessary to strictly control the treatment time, use the drug only when absolutely necessary and take long breaks between treatments. In this case, such complications as argyrosis, a disease characterized by a change in skin color due to deposits of silver ions in its cells, accumulated in the body in excess, are completely excluded.
Drops of protargol
Protargol is a drug intended only for local use in the form of drops, and comes in the form of a 1% and 2% aqueous colloidal solution. It is used for treatment of complicated rhinitis different etiology – protracted purulent rhinitis, sinusitis, etmoidita, frontal sinusitis, with predominantly purulent or complicated by inflammation of the mucous membranes of the eyes (conjunctivitis), for the treatment of recurrent and protracted pharyngitis and nasopharyngitis, for treating adenoiditis and purulent inflammatory middle ear (otitis), as well as in the treatment of inflammatory diseases of the urethra (cystitis and urethritis). And to prevent the development of blepharitis in newborns. In the treatment of inflammatory eye diseases, Protargol is prescribed in the form of a 1% or 2% solution: for adults and children by instilling two to three drops about two to four times a day.
For the treatment of otolaryngological diseases (rhinitis, pharyngitis, otitis) in adults and children, 1% or 2% solution of Protargol is applied by instillation into the nose from three to five drops twice a day each nostril.
The duration of treatment with Protargol is determined by the attending physician.
Where to buy protargol
Protargol solution is not a drug that is freely sold in the pharmacy chain in finished form. It is manufactured by a pharmacist who manufactures medicinal solutions in the production department of a pharmacy. Order and purchase Protargol can only by prescription.
In a small village, usually pharmacies do not have their own production department, which is engaged in the manufacture of drugs, so you have to look for a nearby city where there are such pharmacies, having previously consulted the pharmacy help line or you can also find information on the Internet.
The pharmacy prepares the drops in the pharmacy by simply mixing the dry extract with distilled water, and the process of preparing the colloidal solution takes a little time. But to get dry extract and independently dilute it will not work, due to the fact that it is necessary to adhere to the method of preparation and accurate weighing of all the necessary ingredients.
Protargol for the price is available to each patient, which is 70-80 rubles, but this is not the main advantage of this drug. Unlike a number of ultra-modern drugs – sprays and drops, which are determined by their manufacturers as completely safe and at the same time no less effective drugs than Protargol’s nose drops, they are inferior to him in the spectrum of action on pathogenic bacterial microflora (gram-negative and gram-positive, aerobic and anaerobic microorganisms) and fungal flora. It also does not cause intestinal dysbiosis and addiction is not formed to it. A combination of active anti-inflammatory and astringent effects only complement its quality, speed and effectiveness of action.
But it is also necessary to know, along with the fact that Protargol is a very effective, but not entirely innocuous remedy, which has side effects and contraindications, and also requires precise adherence to the recommendations of the attending physician – the dose, concentration, dose rate during the day and the duration of use. various pathological conditions in adults and children. Therefore, Protargol is not the drug of choice at the initial stage of a runny nose or during a viral infection, the first manifestations of conjunctivitis, or even with suspected sinusitis. He is appointed only in a medical institution, after being examined by a pediatrician, a general practitioner or an otolaryngologist, if absolutely necessary or unsuccessful in treating other drugs.
A solution of Protargol or silver proteinate is a silver-containing protein compound that has a strong astringent, a unique antiseptic and strong anti-inflammatory effect. This tool has the appearance of a brown-yellow powder of a slightly bitter taste and odorless, well soluble in water. The silver content in it is from 7.8 to 8.3%. 1-2 or 5% solutions are prepared from the powder (dry extract) in pharmacies, which are used for topical administration. The disinfecting (antiseptic) ability of the Protargol solution increases in proportion to its concentration. In the same relationship is the severity and frequency of side effects (the higher the concentration – the greater the risk). In this regard, this drug is not prescribed at the first manifestations of conjunctivitis, at the initial stage of rhinitis, or when a banal viral infection. In addition, its use is the exact observance of the recommendations of the attending physician – the dose, concentration, frequency of administration during the day and the duration of use in adults and children. Protargol is prescribed only in a medical institution, after examination by a doctor, when absolutely necessary or ineffective treatment with other drugs. For the treatment of complicated rhinitis with prolonged purulent rhinitis or sinusitis (sinusitis, ethmoiditis and frontitis), for the treatment of recurrent and prolonged nasopharyngitis and pharyngitis, for the treatment of purulent inflammatory processes of the middle ear (otitis) and adenoiditis. And also for predominantly purulent or complicated inflammation of the mucous membrane of the eyes, as well as for the treatment of inflammatory diseases of the urethra (cystitis and urethritis).
But it must be remembered that its use is possible only with good individual tolerance of silver and its protein fractions, strict control of treatment time and use the drug only when absolutely necessary, taking long breaks between treatments.