Alcohol in the first month of pregnancy

In this article, you can read the instructions for use of the drug. Amelotex. Presented reviews of visitors to the site – the consumers of this medicine, as well as the opinions of specialists in the use of Amelotex in their practice A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogues of Amelotex in the presence of available structural analogues. Use for the treatment of arthrosis and rheumatoid arthritis in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Amelotex – non-steroidal anti-inflammatory agent (NSAID), has anti-inflammatory, antipyretic, analgesic action.

Selectively inhibits the enzymatic activity of cyclooxygenase-2. Inhibits prostaglandin synthesis in the area of ​​inflammation to a greater extent than in the gastric mucosa or kidneys. Rarely causes erosive and ulcerative lesions of the gastrointestinal tract.

It belongs to the class of oxycams; an enolic acid derivative.

Pharmacokinetics

Plasma protein binding – 99%. Passes through the histohematic barriers, penetrates into the synovial fluid. It is derived equally through the intestines and kidneys, mainly in the form of metabolites. Less than 5% of the daily dose is excreted unchanged through the intestine; in the urine, the drug is detected in unchanged form only in trace amounts.

Indications

Alcohol in the first month of pregnancy

  • rheumatoid arthritis;
  • osteoarthritis (arthrosis);
  • ankylosing spondylitis (ankylosing spondylitis);
  • inflammatory and degenerative diseases of the joints, accompanied by pain.

Forms of release

Tablets 7.5 mg and 15 mg.

Solution for intramuscular injection (pricks in ampoules for injections) 1.5 ml.

Gel for external use (sometimes mistakenly called an ointment or cream).

Candles rectal 7.5 mg and 15 mg.

Instructions for use and method of use (as a prick drug)

The drug is taken orally during the meal once a day. The recommended dosage regimen for rheumatoid arthritis is 15 mg per day. Depending on the therapeutic effect, the dose may be reduced to

With osteoarthritis –

When ankylosing spondyloarthritis 15 mg per day.

The maximum daily dose should not exceed 15 mg.

In patients with an increased risk of side effects, as well as in patients with severe renal insufficiency who are on hemodialysis, the dose should not exceed

Intramuscularly, deeply – by

Patients with a slight or moderate decrease in renal function (QC more than 25 ml / min), as well as with liver cirrhosis in a stable clinical state, do not require dose adjustment. The initial dose in patients with an increased risk of side effects is

The maximum daily dose is 15 mg in patients with severe renal insufficiency who are on hemodialysis –

Outwardly. Do not apply inside.

A strip of gel with a length of about 4 cm (2 g) is applied 2 times a day with a thin layer on clean, dry skin over the lesion and lightly rubbed for 2-3 minutes.

The duration of the course of therapy is determined individually, may vary depending on the location of the lesion and the marked therapeutic effect and is not more than 4 weeks.

Used by

The maximum daily dose is 15 mg.

Side effect

  • nausea, vomiting;
  • belching;
  • abdominal pain;
  • constipation or diarrhea;
  • flatulence;
  • stomatitis;
  • erosive and ulcerative lesions of the digestive tract;
  • esophagitis;
  • gastritis;
  • colitis;
  • gastrointestinal bleeding (latent or overt);
  • dizziness;
  • headache;
  • noise in ears;
  • confusion;
  • drowsiness;
  • bronchospasm;
  • anemia, leukopenia, thrombocytopenia;
  • peripheral edema;
  • increased blood pressure;
  • flushing of blood on the face and upper chest;
  • heartbeat;
  • increasing the concentration of urea in the blood serum;
  • acute renal failure;
  • interstitial nephritis;
  • albuminuria, hematuria;
  • conjunctivitis;
  • blurred vision;
  • itching;
  • skin rash;
  • hives;
  • photosensitization;
  • bullous eruptions;
  • erythema multiforme;
  • toxic epidermal necrolysis;
  • angioedema;
  • anaphylactoid, anaphylactic reactions;
  • burning and pain at the injection site are possible.

Alcohol in the first month of pregnancy

Contraindications

  • hypersensitivity to the active substance or auxiliary components;
  • contraindicated in the period after coronary artery bypass surgery;
  • uncompensated heart failure;
  • complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses and intolerance to acetylsalicylic acid and other NSAIDs (in

Use during pregnancy and lactation

Amelotex is contraindicated for use during pregnancy and lactation (breastfeeding).

Use in elderly patients

It is used with caution in old age.

Use in children

Contraindicated in children and adolescents under the age of 15 years.

special instructions

In the event of peptic ulcers or gastrointestinal bleeding, the development of side effects from the skin and mucous membranes of the drug should be canceled.

In patients with reduced BCC and reduced glomerular filtration (dehydration, chronic heart failure, surgery), clinically severe chronic renal failure may occur, which is completely reversible after discontinuation of the drug (in such patients, daily diuresis and renal function should be monitored at the beginning of treatment).

With a persistent and significant increase in transaminases and changes in other indicators of liver function, Amelotex should be canceled and control tests should be conducted.

In patients with an increased risk of side effects, treatment begins with a dose.

In the terminal stage of chronic renal failure in patients on dialysis, the dose should not exceed

Caution: To reduce the risk of adverse events, use the minimum effective dose of the shortest possible course for coronary artery disease, cerebrovascular diseases, congestive heart failure, dyslipidemia / hyperlipidemia, diabetes, peripheral arterial disease, smoking, QA less than 60 ml / min, anamnestic data on the development of ulcerative lesions of the gastrointestinal tract, in the presence of Helicobacter pylori infection, in old age, with prolonged use of NSAIDs, frequent use of alcohol, severe somatic In the case of congenital diseases, concomitant therapy with the following drugs: anticoagulants (for example, warfarin), antiplatelet agents (for example acetylsalicylic acid, clopidogrel), glucocorticosteroids (GCS) for oral administration (for example, prednisolone), selective serotonin reuptake inhibitors (for example, citalopram, fluoxetine synthesis, glutocin, and fluoxetine,). ).

Influence on ability to drive motor transport and control mechanisms

During the period of treatment, care must be taken when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and psychomotor speed (when dizziness and drowsiness appear).

Drug interaction

With simultaneous use with other non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of developing ulcerative lesions of the gastrointestinal tract and gastrointestinal bleeding.

Increases plasma lithium concentration; reduces the effectiveness of intrauterine contraceptives, antihypertensive drugs.

Indirect anticoagulants, ticlopidine, heparin, thrombolysis increase the risk of bleeding; methotrexate enhances mielodepressive effect; diuretics increase the risk of kidney dysfunction; cyclosporine enhances nephrotoxic effect; Kolestiramin accelerates excretion. Myelotoxic drugs increase the hematotoxicity of the drug.

Analogs of the drug Amelotex

Structural analogues of the active substance:

  • Artrozan;
  • Bi-xikam;
  • Lem;
  • M Kam;
  • Matarin;
  • Medsikam;
  • Melbeck;
  • Melbeck Forte;
  • Melox;
  • Meloxam;
  • Meloxicam;
  • Meloflam;
  • Meloflex Rompharm;
  • Mesipol;
  • Mixol Od;
  • Mirloks;
  • Movalis;
  • Movasin;
  • Movix;
  • Oxycamox;
  • Exen Sanovel.

Analogs on the therapeutic effect (means for the treatment of arthrosis):

  • Ambene;
  • Apizartron;
  • Artradol;
  • Artrozilen;
  • Aertal;
  • Hydrocortisone;
  • Dexalgin;
  • Diklovit;
  • Diclozan Forte;
  • Dicloran plus;
  • Diclofenac;
  • Dimexide;
  • Is long;
  • Indomethacin;
  • Ketonal;
  • Ketoprofen;
  • Ketorol;
  • Ksefokam;
  • Longidase;
  • Meloxam;
  • Meloxicam;
  • Mydocalm;
  • Movalis;
  • Movix;
  • Nise;
  • Naklofen;
  • Nanoplast forte;
  • Nimulid;
  • Noltrex;
  • Piroxicam;
  • Rapten Duo;
  • Sirdalud;
  • Struktum;
  • Teraflex;
  • Fendivia;
  • Finalgel;
  • Flamax;
  • Chondroxide;
  • Celebrex;
  • Elbona.

Alcohol in the first month of pregnancy

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