Diucha rechovina: 1 tablet is suitable for sildenafil citrate to be equivalent to sildenafil 25 mg, 50 mg or 100 mg; Dopomіzhnі rechovini: kalіyu polakrilіn, magnesium stearate, silica dioxide colohydrate, aspartame (E 951), sodium croscarmellose, flavoring m’yatniy, lactosi monogіdrat, povidon.
Likarska form: Tablets Zhuvalnі.
Fundamentals of the power industry:
three, three, three-sided, two-sided tablets with three “25” stamps on one side; three, three, three-sided, one-sided, three-sided tablets with one “50” stamped on one side; bіlі, trikutnі, vipuklі z oboh bokіv tablets with embossed "100" from one side.
On 1 abo on 2 tablets zhupaln_ at a bl_ster_ at kartonn_y korotts_. 4 tablets each for blister, 1 each 2 each, or 3 blisters each a cardboard box.
The preparation “Grafia®” is recommended to stop cholovik from erectile dysfunction, it is necessary to do something wrong for a successful member of the term member, it is necessary for a successful act of act. For its effectiveness, the GRA® drug is more sexually awake.
Spasіb zasosuvannya dozy:
Drug zasosovuyut orally. For effective drug treatment is more sexually awake.
Doroslі. The recommended dose of the drug is to put 50 mg and zastosovuvitsya raz neobh_dnostі approximately 1 year before the state act. Depot to the effect of tolerance to the drug dose can be made up to 100 mg and reduced to 25 mg.
The maximum recommended dose is 100 mg. The maximum recommended frequency zastosuvannya drug set 1 time for doba. When zasosuvannі pіd hour priyomu їжі dіya drug mozhe nastavat pіznіshe, nіzh when yogo zasososuvannі natche.
Patsі вnti lіtnogo vіku. Necessity at Corektsi doz pati_ntam lіtnogo vіku vіdsutnya.
Patsієnti with nirkovuyu nedikonistyu. Patsiіntam іz nirkovuyu lack of light and the pomirnuyu stage of gravity (klyrens kreatinіnu set 30-80 ml / hv) recommended dose of the drug є analogous dose, induced vyische at rozdіl "Doroslі."
Oskіlki patsієntіv with nirkovuyu lack of a serious step (klіrens kreatinіnu lower than 30 ml / hv) kliren sildenaf_lu znizheny, the dose is recommended to be 25 mg.
Depot to the effect of tolerance to the drug dose can be up to 50 mg and 100 mg. Patsієnti іz pechіnkovoyu negninistyu. Oskilka patsіnntіv іz pechіnkovoyu nediniznistyu (zokremema tsirozom) kliren sildenafіlu decrease, the recommended dose is set to 25 mg. Depot at the same time tolerance to the drug dose can be up to 50 mg or about 100 mg.
Patsіnti, yaki zasosovuyu іnshі lіkarskiі zobobi (for example, ketoconazole, erythromicin, cimetidine, ritonavіr). The detailed information is induced at the “Interconnection with Investigations of the Lіkarskie Sobabes and Introduced in Interviews” section.
Recommended that the dose of the drug should be recommended to patients, supposedly prescribed CYP3A4 іngі_bіtori, for vinata ritonavіru, zastosovannya yakogo at once, sildenafil is not recommended, become 25 mg. With the replacement of the riziku rozvitku orthostatically їpotenzії the camp of patsіnntіv, zakosovuyvat blocker alpha-adrenoreceptorіv, neobhіdno stabilize to the ear zastosuvannya sildenafilu. The recommended cob dose of sildenafil is 25 mg.
Children The drug is not indications for zasosuvannya vіkіm up to 18 rokіv.
– Suspiciousness to active speech abo be active with additional speech to the drug. – Odnochasne zastosuvannya іz nitrogen oxide donors (such yak amіlnіtrit) abo nіtratami at whether yakіy formі, oskіlki vіdomo scho Got sildenafil vpliv on Roads Ahead metabolіzmu nitrogen oxide / tsiklіchnogo guanosine monophosphate (cGMP) that potentsіyuє gіpotenzivny efekt nіtratіv. – The beds, if the state of activity is not recommended (for example, severe sertsevo-sudnnі rozladi, so i’m not stable stenocardia and sertseva lack of a serious step). – Vtrata zoru on one eye of the non-arterial frontal neuropathy of the zorovoy nerve, without regard to the fact that it is connected to the pathology of the pathology of the neuropathic nerve phytotoxico5, chi nі. – Habitat The small number of such fathers of genetically rooted phosphodisterases of viticulture), because the stability of sildenafil has not been reached in such groups of boys.
The safety profile of the drug Grah is based on a tribute to Danish, Otromanic from 74 first-time placebo-control clan dosleen (9570 patients). Naychastіche povіdomlyalosya about taki pobichnі reaktsії, as a golovniy bіl, pour blood, dyspepsia, nasal congestion, bіl at spinі, zapamorochennya, nudota, priliv heat, ruinous zoru, tsianopsіya zaat martenya zoru. Informatia of secondary reactions in the framework of post-marketing cooperation of the company with the help of trivialists more than 10 times. Oskilki applicants povomdomlyosya not about all the vicious reactions that are not all the defective reactions are included in the database of the dan zhzpeki, the frequency of such reactions cannot be properly identified.
Us klіnіchno significant reaction of the reaction, just sposterіgali psd hour klіnіchnih doslіjen part_che, nіzh with zastosuvannі placebo, brought lower vidpovno to the classifiers of the horn of a horn of a horn of a horn of a horn of a horny 150 µmol). Oskіlki pіkovі plasmovі concentrates і Sildenafіlu more than 1 micromolar, injected with the preparation ІGRA® on the class of substrates of cich izofermentiv maloymovіrniy. All times given to each other such sildenafilu such nonspecific іngіbіtorіv phosphodіesteraz, yak teofіlіn that dipimidamol.
In vivo. Oskіlki vіdomo, sildenafіl maє vpliv on metabolism to nitric oxide / cyclic guanosine monophosphate (cGMF) metabolism, has been installed, silo optics juvenile guards, guards, guards, guards, guards, guards, guards, guards, guards, guards, guards, guards Prototype ").
Overnight, zasosuvannya sildenafіlu that blocker α-adrenoceptor can lead to rozvitku symptomatic іpotension і in children who ache to the point of parasitic. This reaction was carried out with the help of 4 years after signing for sildenafil (div. Rozdil “Sposіb zastosovannaya ta dozi” and “Osoblivosty zostosuvannya”). At the end of the year,
In tsikh populiytsіy sposterіgalosya middle dodatkove snezhennya arterіalnogo vice in a prone position at 7/7 mm Hg. Art., 9/5 mm Hg. Art. that 8/4 mm Hg. Art. the middle of the arterial tension in a position standing at 6/6 mm Hg. Art., 11/4 mm Hg. Art., 4/5 mm Hg. Art. відповідно. With a one-hour zasosuvannі sildenafіlu and doxazosin patients, the stability of the camp will be reached at the same time with doxazosin, and there will be a breakthrough in symptomatic orthostatic symptoms. In tsikh pov_domlennyakh ishlosa about vipad zapamorochennya camp before nepatomnistyu, ala without syncope.
Do not ask for meaningful interactions at one hour of sildenafil (50 mg) and tolbutamidu (250 mg) or warfarin (40 mg), CYP2C9 is metabolized.
Sildenafil (50 mg) did not cause a bleeding up to a dozen hours of hemorrhage due to acetylsalicylic acid (150 mg).
Sildenafil (50 mg) is not potentiated by hypotensive alcohol in healthy volunteers at mid-maximal levels of ethanol blood 80 mg / dl.
At patsієntіv, SSMSC zastosovuvali sildenafil not sposterіgalosya zhodnih vіdmіnnostey profіlyu pobіchnih efektіv porіvnyano of placebo odnochasnomu zastosuvannі such klasіv gіpotenzivnih lіkarskih zasobіv, yak dіuretiki blockers, β-adrenoretseptorіv, іngіbіtori ACE antagonіsti angіotenzinu II, antigіpertenzivnі lіkarskі zasobi (sudinorozshiryuvalnі that tsentralnoї dії) , blocker of adrenergic neurons, blocker of calcium channels and blocker α-adrenoreceptors. At the special dosdіdzhennі vzagmodії at a one-hour zasosuvannі sildenafіl (100 mg) and amlodipunu patsіntam from the arterial hypertension that is given to the pre-sigil arterialalnialalto-vai za dés, i’m not allowed to get the same systole in this case, I’m not sure how to find the right one, I’m not sure how to find the right one, I’m not sure what I’m looking for. Art. Vіdpovіdne znizhennya d_astol_chnogo arterialnogo vice became 7 mm Hg. Art. Tsі doodatkovі znizhennya arterialnogo the vise of boules porіvnyannimi іz such, just sposterіgalsya under zastosuvannі lish sildenafіlu from healthy volunteers (div. Rozіl “Pharmacological authority”).
Sildenafil in a dose of 100 mg without having absorbed the pharmacokinetic indications of the implantable HIV protease, sacvinoaviru and ritonavіru, yaki є substrates of CYP3A4.
In healthy volunteers with a stature, it was sildenafil in a dental camp (80 mg tricy for supplementation) induced an AUC and Cmaxbocentan (125 mg dvichi per day) to a pvidvishchennya (125 mg dvichi on the day) by