Side Effects of Simvastatin

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Today, quite a few people suffer from various heart diseases. Due to the fact that modern medicine does not stand still, with these ailments can be dealt with. The most important thing is not to delay and contact a qualified specialist in time. “Lerkamen”, reviews of cardiologists about which will be presented at the end of the article, went on sale not so long ago, but already managed to gain the confidence of not only consumers, but also doctors as one of the best medicines for lowering high blood pressure.

The drug is used to treat various diseases of the cardiovascular system and has a long lasting effect. One pill lasts for 24 hours, so taking the medicine is enough once a day. One of the key benefits of the drug is that it does not affect blood glucose and cholesterol levels. Let’s look at whether this drug is really effective and whether it is better than its counterparts.

General information and composition

“Lerkamen”, the composition of which can be read in the instructions, is highly effective compared to other drugs in this group. The main active ingredient is lercanidipine hydrochloride, which belongs to the group of antagonists of Ca2 ions. They prevent the absorption of calcium by muscle tissue, as a result of which the blood vessels dilate and the blood flow improves significantly, and the pressure gradually normalizes.

Today, Lerkamen is one of the most effective and fast-acting drugs compared to other drugs in this group. Because of this, it can be used for the prevention and treatment of many diseases of the heart and circulatory system among patients of any age group.

“Lerkamen”, reviews of cardiologists about the drug confirm its high efficiency, is available only in the form of tablets, the dosage of the active substance in which can be 10 or 20 milligrams.

Indications for use

More and more cardiologists prescribe “Lerkamen” to their patients.

Indications for use in this drug are as follows:

The drug shows excellent results, because, in addition to high efficiency and prolonged action, it practically does not cause any side effects, regardless of the duration of the course of treatment. To increase the effectiveness of therapy and accelerate the recovery of the patient, cardiologists may prescribe “Lerkamen” together with other antihypertensive drugs.

Instruction

“Lerkamen” (instructions for the drug comes in a box of pills) should be taken in one pill once a day. It is recommended to do this in the morning 15 minutes before a meal. Tablets need to be swallowed whole, without chewing and washing down with a moderate amount of liquid.

At the very beginning of therapy, the daily rate of the drug is 10 milligrams. Gradually, the dosage is increased by 2 times. The duration of treatment is determined by the doctor individually, depending on the clinical picture of the patient and the effectiveness of therapy.

Application features

As medical practice shows, “Lerkamen”, reviews by cardiologists do not contain negative information about the drug, may cause patients to worsen attention and decrease their ability to spatially orient themselves, therefore it is recommended to abandon vehicle control for the duration of taking the drug, since dizziness, drowsiness, and neuropsychiatry sometimes appear. When using grapefruit juice, these manifestations will only increase.

Ethyl alcohol neutralizes the effect of Lerkledilin, therefore during treatment it is strictly forbidden to use any alcoholic beverages.

Side effects

Despite the large number of positive feedback from experienced cardiologists about the drug “Lerkamen”, side effects when taking medication can be. It:

  • peripheral edema;
  • nausea and gagging, indigestion, disruption of the normal functioning of the digestive system;
  • abnormal growth of the soft tissues of the gums;
  • dizziness, drowsiness, and fatigue;
  • skin rashes;
  • increase in heart rate, chest pain, loss of consciousness, heart attack;
  • muscle pain;
  • frequent urination to urinate.

If you are taking Lerkamen (the instructions for use must be studied without fail) and you have any side effects, it is recommended to interrupt the course of treatment and immediately contact an experienced cardiologist to undergo an examination and make the necessary adjustments to the treatment program.

Overdose

If you take the drug in accordance with the recommendations of the doctor, then the likelihood of an overdose is completely excluded. If you exceed the dose and take medication more than the daily norm, then an overdose may be manifested by increased heart rate and a significant decrease in blood pressure. If the overdose was very severe, then the patient may experience bradycardia, as well as loss of consciousness. In case of overdose, you should immediately go to the hospital.

Contraindications

Not all patients who have been diagnosed with any disease of the vascular system, you can take “Lerkamen.”

Contraindications for this drug are as follows:

In addition to all of the above, the use of this drug is prohibited to persons under the age of 18 years. Also, doctors do not recommend taking “Lerkamen” to people suffering from sick sinus syndrome.

Compatibility with other drugs

“Lerkamen”, reviews of cardiologists of which point out that side effects while taking the drug are very rare, can react with quite a large number of drugs, due to which it is often combined to increase the effectiveness of therapy.

Side Effects of Simvastatin

It is usually combined with the following medications:

  1. In some cases, the drug is prescribed in conjunction with diuretics and inhibitors of the angiotensin-converting enzyme.
  2. In the treatment of certain diseases, “Lerkamen” is prescribed together with cardiac glycosides, but in this case the treatment is carried out under the strict supervision of a cardiologist.
  3. Good compatibility of the drug is observed in conjunction with “Zimetidin”. There are no significant changes in the blood plasma.
  4. Extremely careful it is necessary to be at the same time taking the drug with inhibitors of the CYP3A4 group, since in this case the effectiveness of the drug may significantly decrease.
  5. While taking Lerkamena, it is recommended to stop using grapefruit juice and any alcoholic beverages, as they also reduce the effect of the drug on the body.

It is worth noting that “Lerkamena” 5 mg is the minimum dosage of the drug, it is not recommended to combine it with any other drugs, as this can cause various negative manifestations that may pose a threat to human health and life.

Similar medical drugs with identical composition are:

  • “Lercanidipine Hydrochloride”;
  • “Zanidip Recordati”.

In addition, there are several products on sale that have a different composition, but have a similar effect.

Among such funds can be identified:

It is important to understand here that in no case should “Lerkamen” be replaced with any drug without the permission of the doctor, since although they have a similar composition and have a similar effect, nevertheless, the effectiveness of the treatment may be completely different. Many drugs that are used for the treatment of diseases associated with blood pressure, are not able to deal with pathological diseases, and will have only a short-term effect. Therefore, if you have been prescribed Lerkamen tablets, the analogs may simply be useless. In addition, self-medication can be very dangerous, so you should not take another risk.

Drug price

Every person who has been diagnosed with any diseases of the vascular system is interested in the question of how much “Lerkamen” costs. You can buy this drug in almost every pharmacy, and its average cost is 390 rubles, which is not much today. Therefore, given the high efficacy of the drug, there is absolutely no point in replacing it with similar drugs.

Reviews of cardiologists about “Lerkamen”

The vast majority of cardiologists who already have experience with this drug, note its high efficiency. In addition, a great advantage of Lerkamena is that it is perfectly combined with many other means, which allows you to create the most effective treatment program and fight many diseases of the cardiovascular system.

Many doctors prescribe their patients “Lerkamen” also because it is not eliminated from the body along with urine and does not create a large load on the liver and kidneys, so it can be safely prescribed to patients suffering from renal or hepatic insufficiency.

Patient reviews about the drug

“Lerkamen” deserved great recognition not only among cardiologists, but also among patients themselves. Most people choose this drug because of its low cost, high efficacy and long duration. Most people point out that it’s enough to take one pill a day, and you will feel well-being for 24 hours. As for the side effects, they are a single case and are extremely rare. The overwhelming majority of people do not have any negative manifestations, even with long-term use of Lerkamen. Far from all the products of this group that are on the market today can boast of this kind.

Finally

If you are looking for a good medicine for high blood pressure at an affordable price, then Lerkamen will be the perfect choice. But we should not forget that if you have any health problems, you must first be examined by a narrow specialist, and only then begin to take medications. Always keep an eye on your health, because it is impossible to buy it for any money.

In this article, you can read the instructions for use of the drug. Lerkamen. Presented reviews of visitors to the site – the consumers of this medicine, as well as the opinions of medical specialists on the use of Lerkamene in their practice. A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs Lerkamena in the presence of available structural analogues. Use for the treatment of essential hypertension and pressure reduction in adults, children, as well as during pregnancy and breastfeeding. The composition and interaction of the drug with alcohol.

Lerkamen – selective blocker of slow calcium channels with a predominant effect on the vessels, a derivative of dihydropyridine. Inhibits transmembrane current of calcium ions in vascular smooth muscle cells. The mechanism of the antihypertensive action of lercanidipine (the active ingredient of the drug Lerkamen) is due to the direct relaxing effect on vascular smooth muscle cells, as a result of which OPSS is reduced.

Despite the relatively short half-life of plasma, lercanidipine has a prolonged antihypertensive effect due to the high coefficient of membrane distribution. Due to the high vascular selectivity does not have a negative inotropic effect. Acute hypotension with reflex tachycardia is rarely due to the gradual development of vasodilation while taking lercanidipine.

The duration of therapeutic action – 24 hours.

Composition

Lercanidipine hydrochloride + excipients.

Pharmacokinetics

Lercanidipine is completely absorbed after ingestion. Due to the “first pass” effect through the liver, the absolute bioavailability of lercanidipine when taken orally after a meal is approximately 10%; when taken on an empty stomach, the bioavailability value decreases by 1/3. When taking lercanidipine no later than 2 hours after ingestion of fatty foods, its bioavailability increases 4 times, so Lerkamen should not be taken after meals. With oral administration of lercanidipine, its concentration in blood plasma is not directly proportional to the dose taken (nonlinear kinetics). The saturation of the presystemic metabolism occurs gradually. Thus, bioavailability increases with increasing doses. Distribution from blood plasma to tissues and organs occurs quickly and extensively. Plasma protein binding exceeds 98%. About 50% of the dose taken is excreted by the kidneys (about 50% is excreted by the intestine). Elimination occurs mainly by biotransformation. Cumulation of lercanidipine when re-ingestion is not observed.

Indications

  • essential hypertension 1-2 degrees of severity.

Forms of release

Tablets, coated 10 mg and 20 mg.

Side Effects of Simvastatin

Instructions for use and dosage

The drug is taken orally, at least 15 minutes before a meal, preferably in the morning, without chewing, drinking plenty of water.

Assign 10 mg 1 time per day. Depending on the individual tolerance of the drug by the patient, the dose may be increased to 20 mg.

The therapeutic dose is picked up gradually,

The pharmacokinetic profile and data from clinical studies show that elderly patients do not require dose adjustment of Lerkamen. However, care should be taken at the initial stage of treatment with Lerkamen in this group of patients.

When using the drug Lerkamen in patients with mild to moderate renal and hepatic insufficiency, caution should be exercised.

In case of renal failure (CC more than 30 ml / min) or mild or moderate hepatic insufficiency, the initial dose is 10 mg, then with caution increase the dose to 20 mg per day. The antihypertensive effect may be exacerbated in patients with mild to moderate hepatic insufficiency, and dose adjustment (reduction) may be required.

In case of renal failure (CC less than 30 ml / min) and severe hepatic insufficiency, the use of Lerkamen is contraindicated.

Side effect

  • headache;
  • dizziness;
  • drowsiness;
  • feeling of heartbeat;
  • tachycardia;
  • “Flushes” of blood to the skin of the face;
  • angina pectoris;
  • chest pain;
  • fainting;
  • nausea, vomiting;
  • dyspepsia;
  • diarrhea;
  • epigastric pain;
  • skin rash;
  • myalgia;
  • polyuria;
  • hypersensitivity reactions;
  • peripheral edema;
  • asthenia;
  • increased fatigue;
  • myocardial infarction (rarely);
  • pollakiuria (increased frequency of urination);
  • chest pain.

Contraindications

  • untreated heart failure;
  • unstable angina;
  • obstruction of vessels emanating from the left ventricle of the heart;
  • period within 1 month after myocardial infarction;
  • severe liver failure;
  • severe renal failure (CC less than 30 ml / min);
  • simultaneous use with CYP3A4 inhibitors (ketoconazole, itraconazole, erythromycin, ritonavir, troleandomycin);
  • simultaneous use with cyclosporine;
  • simultaneous intake with grapefruit juice;
  • lactose intolerance, lactase deficiency, glucose-galactose malabsorption syndrome;
  • pregnancy;
  • lactation period (breastfeeding);
  • use in women of childbearing age, not using reliable methods of contraception;
  • children and adolescents under 18 years of age (efficacy and safety have not been studied);
  • hypersensitivity to the drug;
  • hypersensitivity to other derivatives of the dihydropyridine series.

Use during pregnancy and lactation

The use of the drug Lerkamen during pregnancy and during breastfeeding, as well as in women of childbearing age in the absence of reliable contraception is contraindicated.

In the course of preclinical studies revealed no teratogenic effect of lercanidipine in rats and rabbits, the reproductive function of rats was unchanged.

Due to the lack of clinical experience with lercanidipine during pregnancy and during breastfeeding, and since it is known that other dihydropyridine derivatives exerted a teratogenic effect in animals, lercanidipine is not recommended for use in pregnancy and in women of childbearing age who do not use reliable contraceptive methods.

Due to the high lipophilicity of lercanidipine, it can be assumed that it penetrates into breast milk, so the drug is not recommended for use during breastfeeding.

Use in elderly patients

Caution should be used in elderly patients.

Use in children

The drug is contraindicated in children and adolescents under the age of 18 years.

special instructions

It should be used with caution in renal (CC more than 30 ml / min) and / or mild and moderate hepatic insufficiency, in elderly patients, in SSSS (without pacemaker), IHD, left ventricular dysfunction.

Influence on ability to drive motor transport and control mechanisms

Since dizziness, asthenia, fatigue and in rare cases of drowsiness may occur during therapy with Lerkamen, patients should use motor vehicles with extreme caution and engage in other potentially hazardous activities that require high-speed psychomotor reactions.

Drug interaction

Lerkamen can be used simultaneously with beta-blockers, diuretics, ACE inhibitors.

When used simultaneously with metoprolol, the bioavailability of lercanidipine is reduced by 50%. This effect can also occur with simultaneous use with other beta-blockers, so you may need to adjust the dose of lercanidipine to achieve a therapeutic effect with this combination.

Lercanidipine is metabolized with the participation of the CYP3A4 isoenzyme, therefore inhibitors and inductors of this isoenzyme, when applied simultaneously, can affect the metabolism and elimination of lercanidipine. The simultaneous use of lercanidipine with CYP3A4 inhibitors (ketoconazole, itraconazole, ritonavir, erythromycin, troleandomycin) is not recommended.

The simultaneous use of cyclosporine and lercanidipine is not recommended.

Caution should be exercised with simultaneous use of lercanidipine with other substrates of CYP3A4 (terfenadine, astemizol, class 3 antiarrhythmic drugs, for example, amiodarone, quinidine).

With simultaneous use of lercanidipine at a dose of 20 mg with midazolam, the bioavailability of lercanidipine in elderly patients can be increased by approximately 40%.

Lercanidipine should be administered with caution simultaneously with inducers of CYP3A4, for example, anticonvulsants (phenytoin, carbamazepine) and rifampicin, since the antihypertensive effect of the drug may be reduced. Requires regular monitoring of blood pressure.

It is necessary to control the presence of signs of digoxin intoxication in patients taking both digoxin and lercanidipine.

The simultaneous use of lercanidipine with cimetidine (up to 800 mg) does not cause significant changes in the concentration of lercanidipine in the blood plasma. With high doses of cimetidine, the bioavailability and antihypertensive effect of lercanidipine may increase.

With simultaneous use of Lerkamena (20 mg) and simvastatin (40 mg), the AUC value for simvastatin increased by 56%, and the same value for its active metabolite – beta hydroxy acid – by 28%. When taking medications at different times of day (lercanidipine in the morning, simvastatin in the evening), undesirable interactions can be avoided.

With simultaneous use of lercanidipine at a dose of 20 mg and warfarin in healthy volunteers, no changes in the pharmacokinetics of warfarin were observed.

Simultaneous use with fluoxetine (an inhibitor of CYP2D6 and CYP3A4) in elderly patients did not have clinically significant changes in the pharmacokinetics of lercanidipine.

It is possible to enhance the antihypertensive effect while taking grapefruit juice and lercanidipine.

Ethanol (alcohol) can potentiate the antihypertensive effect of lercanidipine.

Analogs of the drug Lerkamen

Structural analogues of the active substance:

  • Zanidip Recordati;
  • Lerkamen 10;
  • Lerkamen 20;
  • Lercanidipine hydrochloride.

Analogs for pharmacological group (calcium channel blockers):

  • Agen;
  • Adalat;
  • Acridipine;
  • Altiazem PP;
  • Amlodipine;
  • Amlotop;
  • Verapamil;
  • Vertizin;
  • Diltiazem;
  • Isoptin;
  • Kalchek;
  • Cardilopin;
  • Kordaflex;
  • Cordipin;
  • Corinfar;
  • Corinfar retard;
  • Lekoptin;
  • Lomir;
  • Nicardia;
  • Nimotop;
  • Nifedikap;
  • Nifedipine;
  • Nifecard;
  • Nifelate;
  • Normodipine;
  • Prestanz;
  • Procorum;
  • Stamlo;
  • Tenochek;
  • Felodipine;
  • Finoptin;
  • Cinnarizine;
  • Equacard;
  • Equator;
  • Exforge;
  • Enanorm

In the absence of analogues of the drug on the active substance, you can click on the links below for diseases from which the corresponding drug helps and see the available analogues on the therapeutic effects.

Lercanidipine is a drug for hypertension from the group of calcium channel blockers. In Russian-speaking countries is sold under the name Lerkamen, made in Germany. There are more pills Zanidip, which are produced in Italy. This is the original drug lercanidipine, and Lerkamen is the equivalent.

Lercanidipine for pressure is all you need to know:

  • Official instructions for use.
  • Zanidip is the original drug, Lerkamen is its more popular counterpart.
  • Lerkamen or amlodipine – which is better?
  • How to relieve side effects, including leg edema.
  • Reviews of patients who take this medicine.
  • Effect of Lerkamen and Zanidip tablets on potency.

Modern dihydropyridine calcium antagonists are popular drugs for hypertension. They are in demand because they lower blood pressure well, are comfortable for patients and do not affect the pulse. They can be assigned to “difficult” patients – the elderly, diabetics, and even in difficult situations, pregnant women. Lercanidipine is one of the newest drugs in its group. It causes side effects 5-8 times less frequently than amlodipine, although reviews on the Internet do not confirm this.

Zanidip is an original drug of lecanidipine, made in Italy. Its counterpart are tablets Lerkamen. They are cheaper, although they are also produced in the European Union, in Germany. Coriprene, a combination drug that contains lercanidipine and enalapril in a single pill, is also registered and sold in Russian-speaking countries. While taking lercanidipine, leg edema in patients occurs 2-3 times less frequently than from amlodipine. There is also evidence that the tablets Lerkamen and Zanidip better protect the kidneys and reduce the mortality of patients than amlodipine. We will discuss all this in detail below.

Lerkamen: instructions for use

Lerkamen is a drug of Lercanidipine, and Zanidip is another pill that contains the same active ingredient. Instructions for use Lerkamena read here. Under the link you will find an official document approved by the Ministry of Health of the Russian Federation. However, it contains too many medical terms. If the instruction seems incomprehensible to you, then below in our article you will find all the information in a convenient form. Read the real reviews of patients who take Lerkamen for hypertension and related diseases.

Lercanidipine (Lerkamen, Zanidip): a test of understanding

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    What are the benefits of hypertension in Zanidip and Lerkamen tablets?

    • Good for older people
    • Do not impair the metabolism in patients with type 2 diabetes
    • Do not reduce or increase heart rate
    • All listed and many more.

    Why is Lercanidipine Better Than Amlodipine?

    • Causes side effects, including edema, 5-7 times less
    • Starts to act faster
    • Lowers pressure more

    When does this drug start lowering blood pressure?

    • Within a few hours after taking the pill
    • After 3-5 days of daily intake
    • The real effect appears after 6-8 weeks.

    What is Zanidip?

    • Analogue, made in Italy
    • Original Lercanidipine Tablets

    Are the drugs Zanidip and Lerkamen suitable for the relief of hypertensive crisis?

    Does lercanidipine aggravate male potency?

    • Yes
    • Potency worsens due to vascular atherosclerosis and not medication

    Does this drug aggravate gout?

    • Yes, it is undesirable to take it with gout
    • No, because it does not affect the level of uric acid in the blood

    What is Koripren?

    • Captopril + Lercanidipine Combination Tablets
    • A drug that contains lercanidipine + enalapril
    • Combined medication noliprel + lercanidipine

    Lercanidipine and Amlodipine for hypertension

    Lercanidipine is often compared with another popular calcium antagonist, amlodipine. Both drugs are well suited for the treatment of hypertension in different categories of patients, including the most difficult, for which it is difficult to choose a medicine because of contraindications.

    Pressure Pills: Questions and Answers

    • How to normalize blood pressure, blood sugar and cholesterol
    • The pressure pills prescribed by the doctor used to help well, but now they have begun to act weaker. Why?
    • What if the pressure is not reduced even by the strongest pills
    • What if hypertension medications lower blood pressure too much
    • Increased pressure, hypertensive crisis – features of treatment in young, middle and old age

    Amlodipine and lercanidipine lower blood pressure, reduce the risk of complications of hypertension:

    • in the elderly;
    • patients with type 2 diabetes;
    • people with overweight and metabolic syndrome;
    • patients with heart disease, in which it is not desirable to take beta-blockers;
    • in pregnant women – in the most extreme cases.

    Amlodipine was synthesized in the 1970s. Lercanidipine was developed much later, as a medicine that replaces amlodipine. It has all the same important benefits in the treatment of hypertension, but causes side effects 2-8 times less. Amlodipine is absorbed into the bloodstream and circulates in it for a long time, affecting calcium channels. Due to this, each pill taken lowers blood pressure in 24-30 hours.

    Lercanidipine is absorbed differently. After taking and absorbing the tablets Lerkamen or Zanidip, the concentration of the active substance in the blood decreases after 6-8 hours. But it is not removed from the body, but accumulates in the cell membranes of vascular smooth muscle. From there, lercanidipine is later slowly washed out and has a blocking effect on calcium channels. Each pill of this calcium antagonist reduces the pressure within 24 hours.

    Lercanidipine has the same significant benefits in treating hypertension as amlodipine. However, it causes side effects 2-10 times less. The frequency of edema of the legs drops at least 2-3 times. Rash, dizziness, hot flashes – also occur much less frequently. If you are worried about the side effects of taking amlodipine, then discuss with your doctor whether it is not worth changing it to lercanidipine — Lerkamen or Zandipe tablets.

    The effectiveness of the drug Lerkamen was proven according to the results of many studies in which nearly 20 thousand patients with hypertension participated. Zanidip tablets also underwent clinical studies, but on a smaller scale. Lercanidipine in dosages of 10–20 mg per day lowers systolic “upper” blood pressure by 19–26 mm Hg. Art., and diastolic “lower” pressure – at 13-15 mm Hg. Art. Its hypotensive effect begins after a few days, and fully unfolds after 2-3 weeks of daily intake. Therefore, the initial dose of lercanidipine 10 mg per day can be doubled not earlier than in 2 weeks, if necessary.

    Lercanidipine tablets Lerkamen or Zanidip lowers blood pressure no worse than amlodipine, felodipine and nifedipine slow release in dosages in which these drugs are standardly prescribed. It relaxes and dilates the blood vessels. It does not “slow down” the heart, practically does not affect the pulse rate. It is assumed that lercanidipine also has unique properties – to improve cerebral circulation and protect the kidneys. These properties have not yet been reliably proven, they are only hinted at by articles in medical journals.

    Hypertension in elderly patients

    Thiazide diuretics (especially indapamide) and calcium antagonists, in particular lercanidipine, are considered the most suitable drugs for treating hypertension in the elderly. Tablets Lerkamen and Zanidip do not have a harmful effect on metabolism – they do not worsen the indicators of sugar, cholesterol and triglycerides in the blood. They do not aggravate gout. This means that they can be prescribed for older people who have hypertension combined with other age-related diseases. It is also important that lercanidipine does not affect the pulse. This is essential for elderly hypertensive patients who have heart problems.

    Back in 1997, the results of a small study of the effectiveness of lercanidipine in the treatment of hypertension in the elderly were published. It involved 144 patients aged 60-85 years. They took Lerkamen or pacifiers, and blindly, that is, they did not know which tablets they were given. Among those who were treated with real lercanidipine, systolic “upper” pressure decreased by 15 mm Hg. Art., and the diastolic “lower” – 10 mm Hg. Art. In the placebo group, the upper pressure decreased by 7 mm Hg. Art., the bottom – 6 mm Hg. Art. The drug did not cause orthostatic hypotension. Reviews confirm that older people tolerate lercanidipine well, and this medicine is beneficial for them – it reduces blood pressure, reduces the risk of stroke.

    How to order supplements for hypertension from the United States – download instructions. Bring your pressure back to normal without the harmful side effects that Lerkamen, Zanidip and other “chemical” pills cause. Improve the work of the heart. Get calmer, get rid of anxiety, sleep at night like a child. Magnesium with vitamin B6 works wonders for hypertension. You will have excellent health, the envy of peers.

    Renal failure

    Clinical studies have confirmed the effectiveness of Lerkamena for patients in whom hypertension is combined with impaired renal function. For example, in 2005, the results of a study were published in which lercanidipine treated patients with diabetic nephropathy, as well as non-diabetic renal failure. Lerkamen tablets were added to therapy with ACE inhibitors or angiotensin-II receptor blockers (sartans). As a result, they were able to lower blood pressure to the target level (below 130/85 mm Hg) in 58.1% of patients. The course of hypertension in patients receiving lercanidipine significantly improved in 89.2% of study participants.

    Most patients improved kidney function – decreased urinary protein excretion, increased creatinine clearance. Lercanidipine protects the kidneys because it lowers blood pressure. It is also assumed that he has some other properties for the protection of the kidneys that are not associated with the hypotensive effect. But this is not completely proven. Amlodipine definitely does not have such properties. Pill makers Lerkamen and Zanidip emphasize this in their promotional materials so that doctors transfer their patients from amlodipine to lercanidipine.

    Side effects

    Lercanidipine reduces blood pressure as well as amlodipine and other calcium antagonists that compete with it. At the same time, it causes side effects much less frequently. This is the main advantage of Lerkamen and Zanidip tablets for hypertension. In the early 2000s, the results of two major studies on the efficacy of the drug Lerkamen were published. They included 9059 and 7046 patients. In the first study, the incidence of side effects was 1.6%, in the second – 6.5%.

    The most common side effects of lercanidipine are:

    In elderly patients, side effects of lercanidipine occur no more often than in younger patients. Also, the frequency of adverse reactions slightly depends on the daily dosage of the drug. It can be taken on 10 or 20 mg per day – there will not be much difference. Of course, this does not mean that you can arbitrarily double your dosage, without consulting a doctor. Instead of taking medicine for high blood pressure in high doses, it is better to add another drug to it. Combination therapy is the treatment of hypertension with 2-3 drugs at the same time. It is much more effective than if you take a single drug. Read more “The most powerful pills for pressure – combined.”

    Lercanidipine causes ankle swelling much less frequently than amlodipine. The main reason many patients stop treating with amlodipine is just leg swelling. In this case, it is worth trying to switch from amlodipine to lercanidipine, having previously discussed it with a doctor. With high probability, the swelling will pass completely or at least decrease. Just like other side effects – rash, palpitations, dizziness.

    Please note: edema in patients receiving amlodipine, lercanidipine or other calcium antagonists is not associated with the retention of salt or fluid in the body. This means that diuretic drugs from them are unlikely to help. If a calcium antagonist (lercanidipine, amlodipine, or another) is combined with a drug from the group of ACE inhibitors for hypertension, then the edema in many patients diminishes or completely disappears.

    In 2003, the results of a comparative study of the side effects of lercanidipine, amlodipine, felodipine, nitrendipine and nifedipine GITS (sustained release) were published. After transferring patients from other drugs to lercanidipine, after 1 month, the frequency of edema decreased by 42%, the frequency of headache, hot flashes and rash – by more than 50%. In general, Lercadenipine tablets Lerkamen and Zanidip cause side effects no more often than placebo.

    Lerkamen – patient reviews

    If you read the patient reviews about Lerkamen tablets, it seems that this medicine does not help much, and the side effects from it are significant. Although articles in medical journals claim that the opposite is true. They assure us that lercanidipine and, in particular, the drug Lerkamen well reduces pressure and rarely causes adverse reactions. Who to believe? Reviews on the Internet or official information? In fact, the truth is somewhere in the middle. Reviews of medicines are written mainly by patients who have not been affected by the pills. Or those whom the medicine helps, but at the cost of significant side effects.

    People to whom lercanidipine from pressure did not fit, although very active, but not numerous. Most patients control their hypertension well with this medicine. But they are unlikely to write comments on medical sites, because they calmly go about their business. Reviews of dissatisfied people taking Lerkamen or Zanidip, which can be found in abundance in the Russian and English-speaking Internet, distort the overall picture. Lercanidipine is a relatively good drug for hypertension, with minimal side effects.

    Most of the problems that people complain about drug reviews are not the side effects of pills, but the consequence of the unhealthy lifestyle that the author leads. Of course, it is more convenient to write off your illnesses on the side effects of drugs, instead of going in for physical exercise and stop eating junk food. But if you do not go on a healthy lifestyle, then no medicine will not save from hypertension and other “age-related” diseases.

    Sedentary lifestyle, junk food, chronic stress, race for money and career destroy the human body long before retirement age. Hypertension pills temporarily reduce the pressure, but do not eliminate the causes of the disease. After some time, they are no longer able to muffle the symptoms, and the situation gets out of control. A manifestation of this will be hypertension, resistant to the effects of drugs, and other health problems.

    A low-carbohydrate diet not only normalizes blood pressure for 3 weeks, but also helps against gout. Because the cause of gout is an excess of insulin in the blood. Insulin levels are normalized by a low-carbohydrate diet. After this, gout attacks are no longer bothering, as is hypertension. This technique works many times better than the traditional low-protein diet and anti-gout pills. All information about the natural treatment of hypertension is free. Just read and follow the recommendations.

    Whatever medicine for pressure may be taken, in reviews, people complain that it worsens the male potency. Lerkamen is no exception to this general rule. In fact, the main reason for the weakening of the sexual function is atherosclerosis of the arteries that fill the penis with blood. Many more men in middle age testosterone levels in the blood are below normal. Vascular occlusion and low testosterone are the consequences of an unhealthy lifestyle, and lercanidipine has nothing to do with it. As for the potency, you can save the remnants of the former luxury, and if you are lucky, you can fully recover. Read more about the article “Hypertension and impotence.” It provides specific recommendations on how to treat.

    Reviews of tablets Lerkamen and other antihypertensive drugs too exaggerate the paint. They create the wrong impression that medications do not help in controlling hypertension, but only poison the body with side effects. Many people take medicine well, especially if they are combined with the transition to a healthy lifestyle. On the other hand, articles in medical journals exaggerate the advantages of drugs, because they are paid by manufacturers. Most articles are shameless advertising of drugs aimed at doctors and their patients. The truth is in the middle. Use the method of treatment of hypertension without fasting and harmful pills to abandon the “chemical” drugs.

    How much does lercanidipine reduce mortality?

    In November 2008, the results of a comparative study of the influence of modern calcium antagonists on the overall mortality rate of patients with hypertension were published. Amlodipine, felodipine, nifedipine and lercanidipine were compared. This study was conducted in Australia. Analyzed the statistical reports of the largest insurance company Medicare. We used data from tens of thousands of patients who, from 2003 to 2006, received one of the four drugs listed above. They took calcium antagonists as a single drug for hypertension or as part of a combination treatment.

    It turned out that overall mortality within 4 years in the nifedipine, amlodipine and felodipine groups was 75% higher than among those who took Lerkamen tablets. It turns out that lercanidipine reduces the mortality of patients much better than other calcium antagonists. This is despite the fact that its antihypertensive effect is no more pronounced than that of other drugs. Where does such a sensational result come from? Perhaps due to the fact that the refusal rate of treatment in the amlodipine, felodipine and nifedipine groups of sustained release was 88% higher than in the Lerkamen group. Or maybe Lercanidipine still has some positive properties that have not yet been discovered. This is not yet known.

    The authors of the publication emphasize that their data are not significant evidentiary. They only determine possible directions for future research. However, this information is very interested scientists and medical practitioners around the world. After 2008, many articles appeared in medical journals about the benefits of lercanidipine, in particular, Lerkamen tablets, compared with amlodipine and other calcium antagonists.

    Lercanidipine tablets Lerkamen and Zanidip lowers blood pressure in patients with hypertension no worse than other modern calcium antagonists. At the same time, it causes side effects much less. Patients are especially pleased that leg edema is less common with lercanidipine intake. Due to this, a larger% of patients continue to consistently take pressure pills. This reduces the risk of heart attack, stroke and other deadly complications for them.

    In the Russian-speaking countries only one combination pill is sold – Koripren, which contain lercanidipine and enalapril. However, enalapril is not the best choice among ACE inhibitors for the treatment of hypertension. To use other combined treatment regimens that include lercanidipine, you need to take 2-3 pressure medications at the same time. Patients with hypertension do not like this regimen. If prescribed, patients do not comply with the recommendations, quit treatment. This hinders the replacement of amlodipine with lercanidipine in real medical practice. In Western countries, there are much more combination drugs with lercanidipine.

    Lerkamen – a blocker of slow calcium channels, used in the treatment of diseases of the cardiovascular system.

    Pharmacological action Lerkamena

    The drug Lerkamen inhibits vascular smooth muscle cells and transmembrane calcium current in cardiomyocytes, has a prolonged antihypertensive effect and hypotensive effect, due to the direct relaxing effect on vascular smooth muscle.

    Form release Lerkamena

    According to the instructions, Lerkamen is produced in the form of biconvex, round, film-coated pale yellow or light yellow tablets, with a dye on one side, light yellow on a break, in blisters, in packs of cardboard. One tablet of Lerkamen contains 10 mg of Lercanidipine hydrochloride, 30 mg of lactose monohydrate, 39 mg of microcrystalline cellulose, 15.5 mg of sodium carboxymethyl starch (type A), 4.5 mg of povidone K30 and 1 mg of magnesium stearate.

    Lerkamen’s film coating contains 3 mg of opadra OY-SR-6497, 1.913 mg of hypromellose, 0.3 mg of macrogol 6000, 0.15 mg of talc, 0.6 mg of titanium dioxide and 0.037 mg of iron yellow oxide dye.

    Also according to the instructions, Lerkamen is produced in the form of biconvex, round, film-coated, reddish-pink tablets, painted on one side, light yellow on the break, in blisters, in cardboard packs. One tablet of Lerkamen contains 20 mg of Lercanidipine hydrochloride, lactose monohydrate, microcrystalline cellulose, sodium carboxymethyl starch (type A), Povidone K30, and magnesium stearate.

    The composition of the film shell of Lerkamen includes opadry 02F25077, titanium dioxide, macrogol 6000, iron oxide, talc and hypromellose.

    The analogue of Lerkamena on the active substance is the drug Zanidip-Recordati.

    By analogy Lerkamena on the mechanism of action and belonging to the same pharmacological group include drugs:

    • Agen;
    • Vero-Amlodipine;
    • Zanifed;
    • Cardilopin;
    • Lacipil;
    • Nimopin;
    • Omelar Cardio;
    • Plendil;
    • Sakur;
    • Tenox;
    • Foridon;
    • EsCordi Cor.

    Indications for use Lerkamena

    According to the instructions, Lerkamen is prescribed for essential hypertension of mild to moderate severity.

    Method of use Lerkamena

    In accordance with the instructions, Lerkamen is taken 15 minutes before eating in the morning inside, without chewing and drinking plenty of water. The initial dose of the drug is 10 mg with a gradual increase to 20 mg once a day.

    In accordance with the instructions, Lerkamen is contraindicated for use in:

    • Hypersensitivity to the drug;
    • Aortic stenosis;
    • Lactose intolerance, galactosemia, impaired glucose absorption and galactose syndrome;
    • Chronic heart failure;
    • Severe abnormal liver and kidney function;
    • Unstable angina pectoris.

    Also, the use of Lerkamena is contraindicated during pregnancy and lactation, during the month after myocardial infarction, children under the age of 18 years and women of childbearing age who do not use reliable contraception.

    With caution Lerkamen prescribed for hepatic and renal failure, elderly patients, coronary heart disease and left ventricular dysfunction.

    Side effects Lerkamena

    The use of Lerkamena, according to reviews, causes side effects from various body systems, namely:

    • Peripheral edema, palpitations, tachycardia, lowering blood pressure, chest pain, angina, asthenia, myocardial infarction, fatigue, headache, and dizziness (cardiovascular system);
    • Dyspepsia, vomiting, reversible increase in liver enzymes, epigastric pain, nausea, diarrhea, and gingival hyperplasia (digestive system).

    Also Lerkamen, according to reviews, sometimes causes polyuria, skin rash, myalgia and drowsiness.

    In accordance with the instructions, Lerkamen must be kept out of the reach of children and protected from light, in a dry place, at room temperature up to 30 ° C. The shelf life of the drug in compliance with the recommendations is 3 years.

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