Author of the article: Victoria Stoyanova, 2nd category physician, head of laboratory at the diagnostic and treatment center (2015–2016).
From this article you will learn: what are ACE inhibitors (abbreviated as ACE inhibitors), how do they reduce pressure? What are similar and how different from each other drugs. List of popular drugs, indications for use, mechanism of action, side effects and contraindications of ACE inhibitors.
ACE inhibitors are called a group of drugs that block a chemical substance that promotes vasoconstriction and increased pressure.
Human kidneys produce a specific enzyme, renin, from which the chain of chemical transformations begins, leading to the appearance in the tissues and blood plasma of a substance called “angiotensin-converting enzyme”, or angiotensin.
What is angiotensin? This is an enzyme that has the ability to constrict the vascular walls, thereby increasing blood flow and pressure. At the same time, its increase in blood provokes the production of other hormones by the adrenal glands, which delay sodium ions in the tissues, increase the vasospasm, provoke heartbeat, increase the amount of fluid in the body. It turns out a vicious circle of chemical transformations, as a result of which arterial hypertension becomes stable and contributes to damage to the vascular walls, the development of chronic heart and kidney failure.
An ACE inhibitor (ACE inhibitor) interrupts this chain of reactions, blocking it at the stage of transformation into an angiotensin-converting enzyme. At the same time, it contributes to the accumulation of another substance (bradykinin), which prevents the development of pathological cellular reactions in cardiovascular and renal failure (intensive division, growth and death of myocardial cells, kidneys, vascular walls). Therefore, ACE inhibitors are used not only for the treatment of arterial hypertension, but also for the prevention of heart and kidney failure, myocardial infarction, stroke.
ACE inhibitors – one of the most effective antihypertensive drugs. Unlike other drugs that dilate blood vessels, they prevent vascular spasm and act softer.
ACE inhibitors are prescribed by a general practitioner based on the symptoms of arterial hypertension and related diseases. Independently to accept and establish a daily dose is not recommended.
What is the difference between an ACE inhibitor?
ACE inhibitors have similar indications and contraindications, mechanism of action, side effects, but differ from each other:
- the initial substance in the basis of the drug (the decisive role is played by the active part of the molecule (group), which ensures the duration of the validity period);
- drug activity (the substance is active, or it needs additional conditions to start work, as far as it is available for absorption);
- methods of elimination (which is important for patients with severe liver and kidney diseases).
The original substance affects the duration of the drug in the body, with the appointment it allows you to choose the dosage and determine the period of time through which you need to repeat the reception.