For the drug Finasteride, the instructions for use imply a detailed description of the drug, its components, the frequency of administration, the diagnoses for which it is prescribed, the diseases and conditions in which the drug is undesirable, adverse reactions. Finasteride is an antiandrogenic agent that reduces the activity of the enzyme that converts testosterone to dihydrotestosterone (it is more active). The greater the level of dihydrotestosterone in the blood, the greater the hypertrophy (increase in size) of the prostate. Testosterone is responsible for the formation of typical male traits. Finasteride reduces testosterone.
The composition of the medication is the main active ingredient – finasteride and auxiliary components. Tablets have a special shell, this eliminates their undesirable interaction with the skin, if the integrity of the shell of the tablet is not damaged.
Finasteride is a male drug. It is prescribed to reduce dihydrotestosterone and reduce the size of the prostate, which significantly improves urination. Thus, the reason for the appointment of tablets is:
- an increase in the size and volume of the prostate due to a benign neoplasm;
- reducing the likelihood of acute urinary retention.
The main effects that seek to achieve when prescribing medications:
- prostate volume reduction;
- increase the speed of the current flow of urine;
- preventing complications (acute urinary retention) and reducing the likelihood of prostate surgery;
- decrease urination at night.
Absorbability of the drug is good and does not depend on food intake. Rapidly absorbed, Finasteride reduces the level of dihydrotestosterone in the blood serum, the maximum concentration of the drug is reached after 8 hours. The main ways of removing metabolites of the drug are the intestines and kidneys.
With age, the rate of elimination of the drug from the body slows down. If young people have a half-life of 6 hours, then after the age of 60 years, the half-life of this drug reaches 8 hours. This is a slight difference, and it does not affect the dosage of the drug, depending on the age scale.
In the presence of comorbidities in the form of chronically occurring kidney failure, part of the metabolites of Finasteride, which was supposed to be excreted by the kidneys, goes through the intestines. Therefore, the level of metabolic products of Finasterid increases in the feces, and decreases in the urine. Thus, it is not necessary to regulate the dosage of the drug in patients with renal insufficiency in a chronic course.
Do not recommend taking medication in the following cases:
- allergic to medication components;
- persons under 18;
- female gender and especially the state of pregnancy;
- malignant tumor of the prostate gland;
- acute liver failure;
- old age
Traces of Finasteride get into the seminal fluid in men. The drug, hitting through the seminal fluid in the female body during pregnancy, often provokes a violation of the development of the genital organs in the male fetus. That is why if a person taking Finasteride is a blood donor, he must notify the doctor, because such blood, transferred to a pregnant woman, will disrupt the development of the genital organs of the male fetus.
Side Effects of Finasteride
The undesirable effects of the drug are explained by a decrease in the level of testosterone in the male body. In view of this, a decrease in libido, impotence, and an increase in the mammary glands develops.
The most common side effects are:
- male infertility;
- decreased libido;
- allergic reactions in the form of angioedema, angioedema;
- disruption of the liver (increased liver enzymes – ALT, AST);
- roughness and tenderness of the mammary glands.
The side effects of the 4-year administration of Finasteride did not differ from those taken with placebo.
Finasteride tablets can be taken with other medications, no pathological interaction between them has been identified. There is no information about cases of taking the drug in large doses. Treatment for overdose is not prescribed.
Finasteride tablets are prescribed 1 time per day, regardless of the meal. Duration of treatment usually exceeds 6 months. In case of accidental skipping of the drug, it is recommended to continue treatment in an appropriate dosage, it is strictly prohibited to increase the dose.
In the event that a patient develops adverse reactions as a result of taking this medication, Finasteride analogues are prescribed: Finast, Propecia, Penester, Proscar, Alfinale. The main active ingredient in all of them is Finasteride. All of these analogues differ only by the manufacturer.
In men, when an enlarged prostate gland is detected and in all after 60 years, a prostate cancer is screened. For this purpose, blood is taken from a vein for PSA (a prostatilen-specific antigen). Its increase above the norm is a signal for examination of the patient in order to exclude a tumor disease.
In patients taking the drug, the content of serum PSA is rapidly reduced in the first months of treatment. The free fraction of PSA under the influence of Finasteride is almost unchanged. Therefore, in patients taking the drug for more than six months, it is necessary to double the result of serum PSA, which will reflect the real picture. This is necessary in order not to miss prostate cancer.
When the serum PSA level rises against the background of long-term administration of Finasteride, a careful examination of the patient is required to identify the cause of such growth. In addition to the development of malignant disease of the prostate gland, an increase in serum RPSA indicates an independent cancellation of the drug by the patient.
Isolated cases of breast cancer were detected in men while receiving Finasteride. Therefore, if pain, tightness in the chest or discharge from the nipple is detected, it is necessary to inform the doctor.
Doctors recommend the following precautions:
- Use caution when driving due to the appearance of a side effect in the form of drowsiness.
- Do not use Finasteride and its analogs for expired. After discontinuation of the drug, prostate dimensions return to their original size within a few months.
- Careful administration of the drug with a large amount of residual urine in the bladder due to the high risk of obstructive uropathy and the further need for catheterization and surgical treatment.
In skin cells in the forehead and crown of the crown, testosterone is exposed to 5-alpha reductase, which turns it into dihydrotestosterone, inhibiting hair growth and development. Since Finasteride inhibits the enzyme 5-alpha reductase, hair loss stops or slows down while taking the drug, and sometimes the hair reappears. After discontinuation of the drug, hair loss and baldness resume.
The drug is available in pill form. The cost of Finasteride and its analogues varies from 200 to 2,000 Russian rubles.
The drug Finasteride should be administered exclusively by the attending specialist. If you experience side effects, you must immediately inform the doctor.
During treatment with a drug, it is recommended to periodically donate blood for PSA.