Chapter 4. Clinical and diagnostic evaluation
To summarize the first 3 chapters: I wrote that autism syndrome is a complex, multi-systemic disease that can have implications for the immune, digestive, and nervous systems. The syndrome is increasingly recognized as having a diverse etiology, and certain mechanisms are still being studied, paying attention to genetic and external results.
The more scientists study autism, the clearer the syndrome system is visible. Many of us have concluded that common etiology results from genetic susceptibility caused by external injuries, pathogenic lesions and / or the influence of toxins in early childhood. Since the syndrome affects many major systems of the body, I think that a sick child should undergo a clinical and diagnostic assessment to identify the affected body systems and the pathologies caused by these to determine the subsequent treatment. In this chapter, I will describe the course of my assessment and analysis.
Parents should be aware at first that the complexity of the syndrome lies in the complexity and duration of the healing process. It will take a lot of time, patience, work; can be huge costs of economic and moral resources. Prolonged treatment completely falls on the shoulders of parents, even with the help of an experienced professional.
Parents who are thinking about using the biomedical method may face another problem. Most, but not all, children will get better. For 2003, there is not a single exact method for determining whether a child will improve greatly, or slightly, or not at all. However, the improvements that occur in many children who are diagnosed with autism and who are undergoing biomedical treatment will most likely not occur if the parents and the child’s primary care physician do not explore the current opportunities.
Considering the hundreds or even more children with autism, it can be seen that the forms of the syndrome vary greatly, from child to child. The difference in the history of the disease, health, biological features requires an individual approach to treatment. The first step in my biomedical assessment is to prepare a detailed medical history of the child and his parents in the form of an extensive questionnaire, followed by a survey, preferably directly from a person, or by phone, for those living far away. These stories may give a hint in the definition of a child’s biomedical subgroup of autism. Does the family have autoimmune diseases or allergies? Are there symptoms of viruses, heavy metals and
^ FAMILY AND MEDICAL HISTORY
The questionnaire should have family history details, especially regarding relatives with autism spectrum disorders (ADD, ADHD, FDD, Asperger’s, high-functioning autism), dyslexia, cognitive impairment, autoimmune disorders, Down syndrome, Alzheimer’s disease, mental retardation, and periodical mental diseases depression, bi-polar disorders, schizophrenia. Particular attention should be paid to the mother’s health and the impact of toxins on her, namely:
^ Before conception: maternal health (especially autoimmune condition and any symptoms of impaired immune system), general nutritional status, genetic predisposition both on the paternal and maternal lines, vaccination of the mother during the period close to conception.
^ During pregnancy: the effects of toxins (for example, dental procedures using amalgam), eating large amounts of fish poisoned by mercury, contact with pesticides, heavy metals, mother malnutrition, Rh factors, viral or other diseases, pregnancy complications, medications.
^ During childbirth and early childhood: short, delayed labor, difficult childbirth, difficulties with breastfeeding, allergies to milk and soy in children who are not breastfed, digestive problems, vaccinations, especially with thimerosal, antibiotic treatment.
Problems of gestation and childbirth, the state at birth, weight, APGAR scale, the age of the mother at birth. Medical: duration of breastfeeding, digestive problems, vaccination with any marked reactions, infectious diseases, use of antibiotics, seizures, allergies, surgery, dental procedures. The following details often help a lot:
• Development: general: diet, sleep, stool. Height and weight, compared with the norms of age. Age, when he began to walk, talk, speech delay, any regress in speech, speech strangeness, eye contact.
• ^ Detailed vaccination history: dates, number of simultaneous injections, state of health at the time of vaccination, marked unusual reactions (excessive crying, temperature). Many parents documented the time and amount of ethyl mercury injected with vaccinations, as well as cases of several vaccinations during a single visit to the doctor.
• ^ Nutrition and stool details: how long did they breastfeed when they started drinking milk / soy. Favorite / not favorite food, allergies, the need for special diets and the reaction to them. Nutrition other family members. History of diarrhea, constipation, reflux, the presence of yeast infections, their treatment and results.
• Individuality: attentiveness, fears, phobias, repetitive movements, mood swings, hyper or hypoactivity, outbreaks of irritation, inconsolable crying. Contact: The immediate environment, establishing and maintaining contact, affection, reactions to other children, pets, nannies, teachers, care during the day. Imagination, motor development, right-handedness or left-handedness, eye contact, reaction to changes, sense of humor, independence. The need for special training, the essence of inability to learn.
Many parents usually seek a biomedical assessment and treatment from an autism specialist, if one is available. For these families, the main attending physician is the person who conducts general examinations of the child, routine vaccinations, treatment of infectious diseases, injuries, or chronic diseases. Many ASD children have already been tested to exclude well-known genetic pathologies before parents began to seek help from an autism specialist.
In a biomedical examination regarding autism, this will help a specialist examine the child and his family, noting the child’s relationship with parents, brothers and sisters. General assessment of health, color, overall tone, motor development, attentiveness, eye contact, fearfulness, speech disorders, domination of one of the hands,
establishing and maintaining contact with others allows the doctor to have a basis for comparison with the subsequent stages in the treatment and development of the child. It is instructive to observe how a child plays with toys; Please write or draw something that gives a lot of information about how fine motor skills of a child are developed and how he perceives speech, about the level of thinking. The volume and quality of speech should be noted for comparison with subsequent progress.
In cases where a pre-test assessment (and perhaps subsequent treatment) is carried out remotely, periodic photographs and a monthly report on the condition of the child, written by the parents, will greatly help in documenting progress. For me, communicating by e-mail is a very convenient way to save time and leave a dated entry in the patient’s questionnaire for me and my parents. E-mail is the most convenient way for me to receive a report on the achieved results from parents and give them further recommendations. Unlike the phone, which is more intrusive and less effective than E-mail (if there is someone more busy than a doctor, this is the mother of a child with special needs), this type of communication helps to avoid misinterpretation of my instructions and treatment goals when writing them on paper and dating.
^ New diagnosis in ASD, based on the results of the surveys
Medical history and the survey are accompanied by laboratory tests to detect biomedical problems that need to be corrected. A new diagnosis of autism is based on the results of the surveys. Many of the biomedical abnormalities of an autistic child are difficult to distinguish. The purpose of laboratory tests is not to confirm the obvious disease, but to show the main pathologies. The use of a laboratory examination provides data that often show an unbalanced or even etiologically significant pathology, which determines the basis of subsequent treatment.
For example, testing for heavy metals is particularly important for children who were given hepatitis B vaccine after birth or in early childhood, between 1991 (first mass vaccinations) and 2001 (the year they were banned for newborns). Examination of heavy metals is also recommended for children with autism-spectrum, whose mothers underwent ProGam treatment or removal / installation of amalgams during pregnancy. Children in these categories have a greater risk of being over-exposed to neurotoxic mercury. Proper diagnostic testing for heavy metals is necessary to determine proper and effective chelation (see chapter 7).
Data on thousands of children with autism reveal the existence of “subgroups” of similar biomedical profiles. It is virtually impossible to determine without a full biomedical assessment, which subgroup best describes a child. Without a thorough assessment, it is almost impossible to know which subgroup gives the best description of the child. To get a general picture of the biomedical characteristics of the child, it is necessary to consider together: medical histories, reactions to some simple treatment methods and laboratory data. Despite the existence of subgroups of children with autism spectrum disorders, each case is unique.
^ Initial test evaluation strategies
As I have already said, many autists have intestinal problems, and in my experience, many of them respond well to a gluten-free and case-free diet. This is one of my first recommendations to parents. Hypersensitivity to products can be even in the absence of overt intestinal symptoms, which usually are not a rapid allergic reaction, as recorded by ordinary doctors. In addition, the child can be sensitive not only to dairy or flour products. Hypersensitivity testing for products should be carried out early in the order of diagnosis.
Because many autistic people are hypersensitive to food or digestive problems, many have improved as a result of giving them nutritional supplements.
After several months of a gluten-free and casein-free diet backed up with nutritional supplements, another analysis can be done that will show whether hypersensitivity has changed. Many children who are brought to my examination are already on this diet; in this case, a lot of time is saved.
During the first visit of the child, I prescribe a complete blood count and metabolic group to get the basis for subsequent recommendations. Since intestinal pathogenic bacteria, fungi, parasites are found in many children, a urine test is needed to check the availability of metabolic products of fungi and parasites, and sometimes a stool test is immediately prescribed (see below).
^ MORE TESTS, NEW PHILOSOPHY
With the exception of the usual tests that virtually any laboratory can do (CBC, Chemistry Panel, and Thyroid Panel CBC, chemical analysis, thyroid analysis), most insurance companies do not pay for all (sometimes they do not pay at all) the tests that a child with ASD. Complete tests can cost from $ 1,200 to $ 3,000 (depending on what kind of analysis). It is important that parents understand that even with the availability of all these medically useful data, there is no absolute guarantee that this will help to make a clear diagnosis and prescribe treatment that will certainly work.
In the end, many children who were examined and are undergoing biomedical treatment have made good progress, some even have been diagnosed with autism. Most children make significant progress, but, to varying degrees, remain somewhere “in the spectrum”, unfortunately, another small group of children is progressing little, or not at all. At the moment, there is only one way to check if the method works – try it.
After receiving medical records, starting a diet, introducing some basic nutritional supplements, the choice is expanding. You can make a fairly complete list of tests, at the request of the parents, or subsequent laboratory tests can be done sequentially, several at a time. It depends on the knowledge and understanding of parents regarding the biomedical approach, their medical philosophy, as well as their insurance and financial situation.
When making this decision, parents should be aware that the data obtained at the same time facilitate the realization of their interrelation. The relationship between all major systems is so complex that complete information is useful, provided certain conditions are excluded. When laboratory tests are stretched in time, it is more difficult to create a complete picture of the current state. Therefore, the ideal situation is when all the data about the child was obtained at the time of the assessment, although this is not always possible. Sometimes some tests have already been done before, but the other doctor and for obvious reasons, the parents will not want to repeat the procedure. Such analyzes help, but one-time helps to find a more correct treatment.
^ Parents, Doctors and Philosophy of Analysis
Often the pathologies are hidden and the underlying disease processes are not obvious. For example, a child with an inflamed bowel may, surprisingly, have very few symptoms of this problem or not have them at all, and prior to analyzes that show an overgrown pathogenic flora, often accompanied by a pronounced imbalance of amino acids or vitamins, minerals and lack of fatty acids, inflammation will not be detected.
Parents have different attitudes to the analysis of the child. Some want to get as much diagnostic information as possible. Others do not like the idea of taking blood from a vein so much that they postpone biomedical evaluation for this reason. The instability of insurance companies makes it difficult to solve the problem. Often, autism syndrome is not a diagnosis whose treatment costs are covered by insurance. Often there are hidden disease processes that are important in terms of etiology, and which are detectable and treatable, such as: immunodeficiency, gastroenteritis, heavy metal poisoning, viral infections and
Doctors have different attitudes to testing. Many still believe that the genetic method is the only correct one, and they are skeptical about biomedical analysis. I disagree. On the other hand, the growing number of doctors inclined to biomedical ASD treatment methods allows changing their approaches to clinical treatment methods. Let’s look at a few methods that doctors use.
Some doctors think that it is not necessary to check the child in detail and offer treatment intuitively, relying on the history of the disease and existing problems. Other doctors, who do not have much time, carry out standard diagnostics and treatment, not taking into account the individual biomedical features of the child. On the other hand, some doctors, as a rule, prescribe a complete set of laboratory tests at the beginning of the diagnosis. The latter approach can be useful if the doctor is well versed in the biomedical aspects of autism and is experienced enough to interpret the data set. Sometimes the doctor works with anxious parents who want to undergo a full examination, even if they do not believe that this may be necessary.
I noticed a trend that gives a practical perspective on testing. The more a doctor works with children, the more “simplified” his assessment becomes, and the less testing is necessary, at least in the early stages of the treatment regimen. Later, if the child has additional problems and no progress, then more extensive research (along with more intensive treatment) can and should be considered. As each child is unique, parents should not be surprised if, in a certain situation, consultation with a neurologist, an immunologist, an endocrinologist, a gastroenterologist is required. Examples of such difficult cases are children with severe seizures or children with severe allergies that may have a negative reaction to certain aspects of treatment. These doctors may not know much about autism (for now!), But they know a lot about the medical problems of a particular child related to their specialty.
My method is to prescribe those tests that will give me useful information for prescribing treatment. But since laboratory tests are very expensive and their costs are not always reimbursed, it is important to have a frank conversation with the parents of the child. I try to find out their attitude to the problem, the material possibilities with regard to the medical care of their child. Often, timing is very important, and some analyzes take precedence over others. In addition, the physical retention of a child while taking blood for analysis can injure both the child and the parents. Therefore, I sometimes prescribe painless tests (urine, hair, feces) at the beginning and organize most of the work on the initial examination, which requires blood, so as to take only one blood sample. (a “butterfly” needle, so that everything would be obtained in one venipuncture). Dispensing anesthetic cream (lidocaine
If the initial tests indicate heavy metal poisoning, an assessment of the child’s readiness for oral chelation is very important. We know that for optimal results, the condition of the gastrointestinal tract and nutrition should be maximally improved before beginning chelation. I want to emphasize that chelation therapy, in my opinion, should not be done without a doctor. Some analyzes, in essence, are mandatory. Some will show the presence of metals and their output. Others will show
The health of the child during chelation. Drugs used during oral chelation and detoxification can be harmful to the liver. Some children need to temporarily stop chelation if lab tests have documented liver stress or excessive pathogenic growth. That is why this treatment should be carried out under the supervision of an experienced doctor who knows how to monitor his progress through the most up-to-date tests available at the moment. Medical chelation protocols are available on the Autism Research Institute website and are described in Chapter 7.
Special laboratory descriptions
^ NECESSARY PRELIMINARY ANALYSIS
• CBC (Complete Blood Count) (Differential Blood Test) Differential and Platelet Platelets
• Comprehensive Metabolic Panel Complete Metabolism Scheme
• ^ Diagram of the thyroid gland (T 3, T 4, TSH) of the Thyroid panel (T3, T4, TSH)
These tests can be done in any laboratory nearby and almost always the costs are covered by insurance. They provide information about the health of the child, as well as diseases such as anemia, deterioration of the liver, kidneys, an imbalance in the thyroid gland, this is often the case with ASD children.
In small children, analyzes are taken at home in clean glassware. You can take samples from very small ones using a plastic urine collector. Using urinalysis, the presence of bleeding, infection in the bladder, or confirmation of kidney disease by the presence or absence of bilirubin, protein, or renal colic is determined.
At the moment, parents have already heard about the problem of heavy metal poisoning, and they want to do a hair analysis. In my opinion, this is an informative, non-aggressive and inexpensive analysis. I highly recommend Doctor’s Data Laboratory for this analysis. This lab has probably the largest database related to hair analysis. Hair – more excretory tissue than functional. The analysis of hair elements provides important information that, in combination with the symptoms and other laboratory data, can help the physician in diagnosing physiological disorders associated with abnormalities in the general metabolism and metabolism of toxic elements. The concentration of toxic metals in the hair can be several hundred times higher than in urine and blood. Therefore, hair is the fabric most convenient for determining the total load on the body and the recent contact of the body with arsenic, aluminum, cadmium, lead, and mercury. From my own experience, with the help of hair analysis, one can find out about the presence of mercury poisoning. For example, in many cases, the analysis can determine the presence of mercury poisoning, even despite the fact that (except for recent large exposures) it rarely manifests itself directly in the form of high levels of mercury on vital minerals in the body. Dr. Andrew Cutler, a chemist who suffered for many years and eventually underwent treatment for mercury poisoning due to amalgam, was a great help to specialists involved in chelation by teaching his system of subsetting rules in hair analysis to determine mercury intoxication.
Hair analysis – at its core, however, is preliminary, and often must be accompanied by more specific urine and blood tests, to confirm these results. Recent, not yet published scientific articles show that the hair of autistic children show a lower level of toxic metals than the hair of their close relatives. In fact, this may be additional evidence of impaired detoxification in ASD children.
A blood test should also be carefully considered. Doctors who have not previously dealt with mercury poisoning can prescribe a blood test for mercury, and, having received a negative result, convince parents that their child is not poisoned with mercury and does not need chelation. But the blood test shows only recent significant poisoning, and does not show the presence of mercury in the brain, which is located beyond the blood-brain barrier and is not available for evaluation by a blood test. I was already disappointed by doctors who refused to conduct research after receiving a negative blood test; parents should know that the doctor who does this is not aware of new biomedical methods of treating mercury poisoning in ASD children.
The analysis must be appointed by the attending physician. Doctor’s Data Lab charges $ 42 for this service if you send a payment along with a hair sample.
Special laboratory tests for individual indications
I recommend a complete blood count, chemistry of metabolism, a diagram of the thyroid gland as essential for all children. Specific tests are prescribed in accordance with the symptoms and history of the child’s illness and often include tests of the immune system, tests for viruses and fungi, and peptide tests for the tolerance of wheat and milk. The last analysis I do only for those parents who are categorically against a gluten-free and casein-free diet to prove that their children really do not tolerate these large doses of peptides. Tolerance to a large number of products and plasma amino acid analysis will help to make the right diet for a child. Preliminary analyzes often reveal the need to treat candida, or other overgrown pathogens, and eliminating products containing wheat, milk, and even soy, is one of the first steps. The treatment of these diseases is described in Chapter 5. Blood tests, feces, urine can identify pathogenic microorganisms or pathogenic metabolites and provide the basis for anti-pathogenic treatment. A blood test helps to focus on areas where biochemistry can be improved by proper supplementation. Analyzes of hair, urine, and blood, taken together, will help determine whether there are heavy metals in the body and direct their removal, as well as the necessary mineral and nutritional support for chelation. Proper control during the treatment process helps to precisely regulate the dosage of medicines and supplements, and to maintain the optimal health of the child during treatment.
There are many more advanced analyzes for special cases, if this is required for clinical development, but these are the ones that I usually find useful in my practice at the initial stage of evaluation. Some children with seizures may need the help of a neurologist to undergo a 24-hour electroencephalogram if this has not yet been done. Severe cases of infection with severe immunological disorders may require the help of an immunologist or an infectious disease specialist. Some digestive problems are so serious that the child must be referred by the gastroenterologist for endoscopy. Less often, a child has to go to an endocrinologist for the treatment of diabetes or severe thyroid abnormalities, or an allergist to treat severe asthma. Usually such
Professionals are consulted before bringing a child for a biomedical assessment relating to autism. It is important that the attending physicians of the child work as a team in order to avoid contradictions of treatment methods, even if ordinary doctors know little about the biomedical approach to autism. Parents need to be prepared for the fact that some doctors may be wary of information and treatment methods that they do not yet understand, and therefore are skeptical about the use of diets and supplements during the treatment of their children.
^ PEPTIDE URINE ANALYSIS FOR CASEIN AND GLUTEN
This is a chromatographic assay for exorphin peptides, including also large peptides produced by wheat (gluten) and milk (casein). Quantitatively accurate measurements of these peptides do not yet take place in the field of routine clinical analyzes, and the results in terms of clinical use have been very confusing for a number of years. An accurate measurement of the amount of these peptides is not yet possible in the conditions of ordinary laboratories, and it is very difficult to predict the timing of implementation. In children with high rates, intestinal symptoms or any benefit from removing casein and gluten from their diet may not appear; Many children with normal outcomes can respond surprisingly well to a casein-free and gluten-free diet. I almost do not prescribe this analysis, except when the parents insist on it, hoping that the result will save their child from the diet. Nevertheless, despite the result of the analysis, especially if the child has limited nutrition and any problems with digestion, I advise you to go on this diet.
Parents, in most cases, are often surprised and rejoiced at the apparent clinical progress even before chelation begins. This includes the varied diet of their children, adherence to strict schedules of medical chelation, and passing the tests necessary for proper treatment. I also noticed that parents’ willingness to put children on a diet often shows their desire to undergo a complicated course of treatment, which includes the use of nutritional supplements, adherence to strict medical procedures and carrying out the necessary tests for treatment.
^ ANALYSIS ON ORGANIC ACIDS (URINE)
I prescribe an analysis of organic acids due to the ubiquity of the yeast problem and imbalance of metabolism. The organic acid test measures the amount of key components in a child’s biochemical processes. The function of metabolism, tested by analysis of organic acids, shows how efficiently the metabolism of the child occurs, how well the food is processed, and what problems may occur. The analysis is extremely important to identify those microbial imbalances that cause an increase in metabolic toxins that can be detected in the morning urine. As mentioned earlier, many cases of yeast infections show signs of chronic diarrhea, constipation or alternation, as well as gas, bloating, gastrointestinal discomfort, foul-smelling stools. However, I often encountered children who, using laboratory tests, detected an excessive amount of yeast, but did not have obvious symptoms. Clinically, if a child remains very picky about food, I suspect intestinal inflammation and pathogenic colonization, despite the absence of symptoms.
^ 90-products. IgG antibody assay (SERUM)
Delayed or latent sensitivity to food is usually not noticeable for several hours or days after meals. Often these reactions show a constant exposure to commonly eaten derivatives of products such as corn, wheat, milk, eggs. This complex group is a valuable tool in the treatment of patients with allergies. For children who are not helped by the diet, or helped, but only at first, I recommend doing this analysis to make sure that some of the usual foods do not affect them. IgG detects delayed sensitivity (not IgE, or an instantaneous allergic reaction), which is more often
worried about children with autism. In this sense, it is more a sensitivity analysis to products than an allergic analysis, which shows that even without obvious allergic reactions, these products irritate the intestines and contribute to its long-term inflammation. After excluding these foods from the diet, the child takes another leap in the recovery process.
Amino acids are building materials for proteins and are necessary for many processes in the body. The digestive system breaks down the protein coming from food into amino acids that enter the blood. These amino acids:
• Build structural proteins of muscle and connective tissue
• Make up enzymes that control every chemical reaction in the body
• Produce a range of transmitters and brain hormones
• Stabilize blood sugar
• Help in detoxification and antioxidant protection
Due to poor diet or inadequate digestion and protein absorption, many ASD children have an amino acid imbalance. The overwhelming majority of these problems are caused by impaired digestion or impaired metabolism of methionine and cysteine, as well as a lack of taurine. Low levels of taurine can adversely affect the detoxification and absorption of essential lipids from food, which can lead to a lack of vitamins A, E, D and essential fatty acids. To do a basic analysis, you must first do an amino acid test, thus: the child eats his usual food, without food additives, for 3 days before the analysis. Subsequent tests are done when the child follows his diet, which includes supplements. More information can be collected using the study of daily urine for the presence of amino acids, but with autists it is very difficult, so I usually do a fasting plasma test.
^ COMPREHENSIVE MICROBIAL / DIGESTIVE ANALYSIS OF KALA
For children who continue to have intestinal problems while on a diet and using probiotics, this is an important study of the digestive tract that is necessary for further treatment. This analysis helps to assess the digestion, absorption of substances, the intestinal flora, the state of immunity, the development of colonies of bacteria, and to determine the presence of parasites using microscopic analysis. The sensitivity panel for the treatment of pathogenic flora is being done by several laboratories, but this requires a specific request and additional costs, of course. However, this analysis is invaluable in the treatment of re-infection by pathogenic microorganisms in order to ensure the use of a properly chosen antifungal or antibiotic drug.
^ ANALYSIS OF FATTY ACIDS (PLASMA)
Autists usually have a very poor diet, especially food containing “good fats,” found in vegetables, nuts, whole grains and fish (which is not recommended because most fish have mercury). The hydrogenation process used in modern food processing destroys important fatty acids and creates structurally modified fatty acids, called trans fatty acids, which can harm the body. See more on fatty acids in Chapter 6.
Plasma analysis of fatty acids can show more than 30 different fatty acids in the body – initial and their derivatives, saturated and transfatty acids. This analysis usually goes further in my sequence of analyzes, unless malnutrition is evident at the beginning of the diagnosis; I always prescribe it for ADD-ADHD or for bipolar children, the more I study, the more data show the effectiveness of treating these children (and adolescents) with fatty acids. This analysis helps me modify food and supplements that can balance their fatty acid levels.
^ METALLOTHONEINE DYSFUNCTION TEST
Dr. William Walsh, from Fafer Treatment Center, located in Naperville, believes that metallothionein (MT) dysfunction is one of the primary causes of the onset of the syndrome. 85% of the children studied showed an increased ratio of copper / zinc in the blood compared to healthy ones. He tests: plasma zinc, serum copper, plasma ammonium, pyrrole urine and ceruloplasmin to balance patient biochemistry with minerals, especially zinc, and other additives.
MT protects cells from the harmful effects of free radicals, DNA damage and the toxicity of excess heavy metals. Since it is an intracellular protein, only cellular activity is important in determining the toxicity of metals; plasma analysis for MT level is not essential. I use a functional MT study, which analyzes the cellular level of MT expression before and after stimulation with metals, as performed by the laboratory of immune sciences in Beverly Hills, to approximately determine the effectiveness of MT protection. This analysis, together with the hair analysis and the RBC mineral test, show whether the patient needs chelation.
As each of us working with autistic children, Dr. Walsh found that the most difficult thing to treat is a high percentage of acute intestinal problems. In his treatment protocols with a chemically rebalanced diet, he said that with regular use of special diets, drugs to improve digestion, probiotics, and the exclusion of sugar from the diet, the results of treating autistic children improved dramatically.
^ Laboratory tests in chelation therapy
Primary tests to prepare for chelation. (see Chapter 7 on the chelation protocol):
• Standardized preliminary tests, which are highlighted above, to check overall health;
• A urine / feces test to ensure that the intestines are healthy, such as OAT (organic acid analysis) and CDSA;
• Hair analysis (see above);
• Mineral analysis of the red blood cell to facilitate the mineral / nutrient plan;
• Analysis of urine for heavy metals before and after the introduction into the body of a substance that provokes their excretion. Such tests are often not needed and are performed when the parents want it, or are sent by a doctor, who may not be sure that the child will benefit from chelation. A regular morning urine test is taken (before the substance is injected), then two doses of a chelator are given, usually DMSA (Chemet. Or 2.3 dimercaptosuccinic acid), calculated by the weight of the child and given overnight and the next morning. The analysis after administration is obtained by taking a portion of urine within a few hours after the morning dose. The chelator is attached to the metals contained in the urine, and the test results before and after the introduction of provocative
substances are compared to see what the reaction to chelation may be. Details in Chapter 7.
Because of its high technology, the discussion of this analysis is in Chapter 8, where the immune system is covered in detail.
What labs are suitable
The question of which laboratory to use is very important. Preliminary analyzes are simple and can be done anywhere.
If the doctor has his own venopunktora in the office, this is ideal. If not, it is very important to help the patient find the nearest laboratory where they will agree to take blood for a specialized laboratory and work with special children. Such laboratories often specialize in autism and make tests that are not available in regular laboratories. In this case, test kits are issued to the patient by the attending physician, or are sent to the patient by the laboratory at the request of the doctor. Laboratories with which I personally work:
CALIFORNIA Immunosciences Lab (ISL)
GEORGIA Meta-Metrix Lab (MML)
ILLINOIS Doctors’ Data Lab (DDL)
KANZAS Great Plains Lab (GPL)
NORTH CAROLINA Great Smokies Lab (GSL)
All of these laboratories send test kits to clients at the request of the doctor. Many people send duplicate results to the attending physician so that the patient can have one such for his files.
I am sure that there are other good laboratories; each doctor must, through experimentation, find a laboratory with which he loves to work. Using the same laboratory for a specific analysis with all of my patients helps me relate the results of the analysis to the symptoms that I see clinically. This approach helps me to get acquainted with the laboratory staff, so that I can get answers to my questions. The ease of reading the reports, the time to get the results, the availability of the laboratory directors for discussing the results of the analysis – all this is often important for me in choosing between equally good laboratories.