Diflucan side effects

Diflucanone Diflucan

Pharmachologic effect:The active ingredient of Diflucan – fluconazole – has the property of effectively inhibiting the synthesis of sterols in the cells of fungi. Diflucan proved the effectiveness of anti-yeast and yeast-like fungi (Candida spp, Cryptococcus neoformans), fungi (Histoplasma capsulatum, Blastomyces dermatitides), dermatophytes (Trichophyton spp, Microsporum spp), dimorphic forms (Coccidioides immitis). Diflucan is rapidly absorbed from the digestive system, reaching a maximum concentration already after

Indications for use:– candidiasis, including generalized forms, candidemia, candiduria, candidiasis in the presence of immunodeficiency, immunosuppressive therapy, prevention of candidiasis in patients with HIV infection and AIDS; – cryptococcosis, including cryptococcal meningitis, cryptococcosis on the background of immunodeficiency, immunosuppressive therapy, prevention of candidiasis in patients with HIV infection and AIDS; – mycoses of the skin, including scaly deprive; – onychomycosis; – other mycoses (histoplasmosis, coccidioidomycosis, sporotrichosis, paracoccidioidomycosis).

Mode of application:The effective daily dosage is calculated individually, depending on the pathology and the severity of the disease. For the treatment of genital candidiasis, as a rule, a single application of Diflucan is required. The administration of Diflucan for other pathologies should last until the disappearance of objective and subjective symptoms. Patients with low immune status (AIDS, immunosuppressive therapy, malignant neoplasms), as a rule, need maintenance therapy after completing the main course of therapy. For the treatment of cryptococcosis, the following scheme is used: on the first day the recommended daily dose is –

Treatment of generalized forms of candidiasis, cadidemia begins with a daily dose

For the treatment of vaginal candidiasis, Diflucan is usually enough in a dose

For the treatment of pityriasis versicolor, Diflucan is prescribed in a dose of

Diflucan side effects

Side effects:In most cases, Diflucan is treated without side effects. In rare cases, the following adverse effects are observed: • from the nervous system: headache, convulsions, dizziness; • on the part of the skin – allergic manifestations, up to Stevens-Johnson syndrome and Layel syndrome, alopecia; • on the part of the gastrointestinal tract: abdominal pain, changes in the level of liver tests, dyspepsia, toxic (drug) hepatitis; liver failure, even death; • common: anaphylaxis, change in taste, hematopoietic depression.

Contraindications:Known intolerance to fluoconazole or any of the components of the drug. The simultaneous appointment of Diflucan with terfenadine or cisapride is contraindicated. A relative contraindication is pregnancy or the period of breastfeeding, since there are no data on the degree of safety of the use of Diflucan during these periods.

Pregnancy:The use of Diflucan during pregnancy is undesirable, the drug can be used only for health reasons.

Interaction with other drugs:Anticoagulants (coumarin series): when used together with warfarin, prothrombin time may increase, which can lead to bleeding, therefore, if they are given at the same time, constant monitoring of the coagulogram and prothrombin time is necessary.

Hydrochlorothiazide: with the joint intake of these drugs may increase the concentration of fluconazole by 40%, which should be taken into account by the attending physician.

Benzodiazepines: simultaneous taking of midosolam and fluconazole may lead to an increase in benzodiazepine concentration and the development of psychomotor reactions. If the combined use is necessary, it is recommended to reduce the dose of Diflucan and carefully monitor the patient’s condition.

Cisapride: with simultaneous use with Diflucan may develop ventricular arrhythmias, like pirouette, including fatal forms, so their combined use is contraindicated.

Cyclosporine: data on the joint intake of cyclosporine and Diflucan are contradictory, in some studies there was an increase in the concentration of cyclosporine, in others it was not detected. If necessary, their joint use is recommended to regularly determine the concentration of cyclosporine in the serum.

Oral contraceptives: the use of fluconazole in high doses can lead to an increase in the level of ethinyl estradiol and levonorgestrol.

Phenytoin: Fluconazole may cause an increase in the concentration of phenytoin, therefore, if they are given at the same time, dose adjustment and constant monitoring of the concentration of phenytoin in the blood is required.

Rifampicin: can lead to a decrease in the concentration of fluconazole and its more rapid removal, so if you need their joint reception, it is recommended to increase the dose of fluconazole.

Sulfonyl Urea Derivatives: can be used in conjunction with fluconazole, but it should take into account the risk of hypoglycemia.

Theophylline: Fluconazole can lead to an increase in theophylline concentration, therefore, in cases where their simultaneous use is needed, a dose adjustment of theophylline is necessary.

Astemizol: simultaneous reception can take place only with careful monitoring of the level of astemizole in the blood plasma due to the possibility of increasing its concentration.

Terfenadine: at the same time, prolongation of the Q – T interval is possible, which can lead to arrhythmias, including fatal ones. The combined use of these drugs is possible only in the case when fluconazole is used in a dose of less

Diflucan side effects

Overdose:Cases of overdose are described, with the clinic of development of psychomotor reactions. Treatment consists of accelerating the excretion of fluconazole from the body, through gastric lavage, hemodialysis, and symptomatic therapy is also justified.

Diflucan side effects

Release form:Diflucan Capsules 50 mg, 7 capsules per pack. Diflucan Capsules 100 mg, 7 capsules per pack. Diflucan Capsules 150 mg, 1 capsule per pack. Diflucan solution for infusion 2 mg per 1 ml, 50 ml vial. Diflucan solution for infusion 2 mg per 1 ml, 100 ml in a vial.

Storage conditions:It is recommended to store Diflucan in a place, reliably protected from direct sunlight, the temperature in the room should not exceed 27 degrees Celsius.

Synonyms:Difluzol, Mikomax, Mikomaks 150, Mikomaks inf., Mikomaks sir., Mikosist, Fluconazole Sandoz, Flukonorm, Fluorkor, Fucis, Fucis DT.

Composition:Diflucan Capsules 50 (100, 150) mg: Active ingredient: fluconazole 50 (100, 150). Additional substances: corn starch, colloidal Si dioxide, Mg stearate, Na lauryl sulfate, lactose.

Diflucan solution for infusion: Active ingredient: fluconazole 2 mg per 1 ml. Additional substances: Na Cl.

Additionally:Due to the fact that fatal cases associated with liver damage are described, careful control is required of patients who have changed transaminase levels during the process of treatment with Diflucan. Elderly patients do not need to change the dosage of Diflucan, while in patients with impaired renal function, the dose is selected depending on the level of creatinine after the first (loading) dose. When breastfeeding, the administration of Diflucan is not recommended, therefore breastfeeding should be discontinued during therapy.

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