Analysis of organic acids – determination of the concentration of various organic acids in the urine, the appearance of which indicates a violation of the metabolic pathways in the body and is a marker of diseases from the group of organic aciduria.
The list of tests in the study:
- Glycolic acid;
- 3-hydroxybutyric acid;
- Methyl malonic acid;
- 2-ethyl-3-hydroxybutyric acid;
- 2-hydroxy isocaproic acid;
- Ethyl malonic acid;
- Succinic acid;
- Glycerol (D, L-isomer) acid;
- Glutaric acid;
- 3-methylglutaric acid;
- Glyoxylic acid;
- Adipic acid;
- Pyruvic acid;
- Mevalonic acid;
- 3-hydroxy-3-methylglutaric acid;
- 4-hydroxyphenylacetic acid;
- N-acetyl-parpartic acid;
- Suberic acid;
- Homogentisic acid;
- Hippuric acid;
- Sebic acid;
- Phenylpyruvic acid;
- 4-hydroxyphenylpyruvic acid.
Organic acids are intermediate decay products of many substances, the exchange of which takes place in the human body. They play a major role in the conversion of energy from nutrients, are intermediate products of metabolism. The concentration of organic acids reflects the level of carbohydrate metabolism, characterizes the functioning of mitochondria and the process of cellular respiration in them. Organic acids measured in the study are the main components, as well as intermediate products of metabolic energy conversion during the Krebs cycle.
Indications for use in adults: Analysis of organic acids can detect abnormalities in metabolism due to intoxication, intestinal dysbiosis, pathological changes in blood glucose concentration, oxidative load, nutritional deficiencies, poor nutrition and other causes.
Symptoms suggest an imbalance of organic acids in the body:
- chronic ailments, headaches;
- fibromyalgia, reduced skeletal muscle tone, muscle and joint pain;
- low endurance of the body.
Indications for use in children: Analysis of organic urine acid is an important step in the examination of a child suspected of congenital metabolic disorders.
The study is conducted in the presence of:
- specific, strange smell of urine;
- metabolic acidosis, transient or permanent, with an increased or normal anion interval;
- persistent vomiting, especially if metabolic acidosis is observed;
- acute illness in infancy, especially if there is hyperammonemia and metabolic acidosis;
- progressive extrapyramidal symptoms;
- Reye’s syndrome, especially when occurring in infancy, in the presence of repeated attacks and burdened hereditary history;
- any hereditary disease with an unidentified cause.
Preparation On the eve of the analysis, it is not recommended to eat vegetables and fruits that can change the color of urine (beets, carrots, cranberries and
Collect strictly morning portion of urine, allocated immediately after sleep. Before collecting the urine, a thorough hygienic toilet of the external genital organs must be carried out. When you first urinate a small amount of urine (the first 1-2 seconds) to release into the toilet, then collect the entire amount of urine in a clean container without interrupting urination. Pour urine into a sterile plastic container with a screw cap of approximately 50 ml. During urine collection, it is advisable not to touch the body container. It is necessary to deliver the container with urine to the medical office as soon as possible after taking the biomaterial.
Women are not recommended to take a urine test during menstruation.