Allergy nasal spray

TIZIN ® Alergi is specially developed for the treatment of allergic rhinitis and acts locally due to its levocabastine. It is an antihistamine that selectively blocks H1-histamine receptors and reduces the severity of symptoms of AR or symptoms caused by an allergic reaction. This drug is recommended for use in allergic rhinitis, pollinosis in children from 6 years and adults. TIZIN ® Allergy quickly helps to eliminate the symptoms of allergies: rhinorrhea, sneezing, nasal itching.

TIZIN ® Alergi is a local antihistamine drug based on levocabastine, created specifically for the treatment of allergic rhinitis (pollinosis). The drug in a convenient form of spray helps in just 5 minutes to alleviate the symptoms of allergic rhinitis and get rid of itching in the nasal cavity, sneezing, rhinitis. The drug is approved for use in children from 6 years and adults.


What causes allergies and runny nose?

Spring allergies in adults and children are characterized by the following main symptoms: runny nose, itching in the nose and eyes, sneezing, impaired breathing, lacrimation, eyelid edema. The spread of inflammation in the bronchi is accompanied by the appearance of cough, shortness of breath, wheezing, shortness of breath. Rarely can develop allergic dermatitis, urticaria. Runny nose and other symptoms appear during the flowering period of the plant, to which the body of a child or an adult is sensitive.

Symptoms of pollen intoxication

What causes allergies?

Allergy nasal spray

Before you understand what to do with allergies and how to treat it, it is necessary to determine the causes of its occurrence. Allergy symptoms in children and adults usually manifest themselves with an increase in sensitivity to the effects of a particular environmental factor.

Spring allergy in adults and children occurs in response to pollen, the maximum concentration of which is usually observed in the early morning hours. Favorable conditions for palination (dusting) are sufficient humidity and sunny warm weather. Spring allergy most often occurs on pollen of birch, hazel, alder; as well as ambrosia and wormwood.

How to distinguish pollinosis from other diseases

Only a doctor can decide what to do with allergies in a child or an adult. To diagnose and prescribe treatment should contact an allergist. Also, depending on the identified symptoms (runny nose, conjunctivitis, etc.), the doctor may recommend consulting other specialists. To understand what to do with allergies and how to get rid of it in each case, the doctor collects a medical history, conducts a thorough examination of the child or adult and may order additional research.

Seasonal allergies in children and adults

Seasonal allergy in adults and children (hay fever or hay fever) is a reaction to an allergen that exists, as a rule, only at a specific time of the year, for example in the fall or spring. It manifests itself in many children and adults, however, it often remains not diagnosed and help for allergies does not come in time.

How to treat pollinosis?

Preventive measures can be divided into primary measures that need to be carried out by those who are subject to an adverse reaction to allergens, as well as people in risk groups (gardeners, beekeepers, agricultural workers), and secondary ones for people suffering from seasonal manifestations of allergic reactions. .


Prevention of the onset of rhinitis and other manifestations of hay fever in the spring and fall consists in observing the correct mode of work and rest, a balanced diet and keeping contact with substances of an allergenic nature to a minimum. So that in the future there is no question of what to do with an allergy in a child, prophylactic monitoring is necessary to identify respiratory diseases, which in a chronic course can lead to an increase in the sensitive child’s body to seasonal allergens.


Help with allergies is not only taking medications. To prevent the occurrence of a runny nose with allergies and other unpleasant symptoms in adults and children, it is recommended to: limit your stay in places where there is a large accumulation of different plant species, wear sunglasses and closed clothing in spring and summer; get rid of old upholstered furniture, remove carpets, etc .; timely treat acute infectious-allergic diseases; regularly ventilate and clean the rooms in the house, etc.

1 ml of the preparation contains:

active substance: Levocabastine hydrochloride (0.54 mg) in terms of 0.5 mg levocabastin;

Excipients: propylene glycol 48.26 μl, sodium hydrogen phosphate 8.66 mg, sodium hydrogen phosphate monohydrate 5.38 mg, hypromellose (2910 5


Pharmacotherapeutic group – antiallergic agent – H1-histamine receptor blocker.

ATX code – R01AC02

Pharmacodynamic properties

Levocabastin is a selective blocker of H1-histamine receptors with a long lasting effect. The local effect occurs after 5 minutes, and the action lasts for 12 hours. After intranasal administration, nasal spray “Tizin ® Alergi” eliminates the symptoms of allergic rhinitis: nasal discharge, sneezing, itching in the nasal cavity.

Pharmacokinetic properties

With each intranasal administration at a rate of 50 µg / dose, approximately 30–40 µg of levocabastin is absorbed, the maximum concentration of levocabastin in the blood plasma is reached approximately 3 hours after nasal administration. Levocabastin is approximately 55% bound to plasma proteins.

The main metabolite of levocabastine, acylglucuronide, is formed during glucuronidation, which is the main metabolic pathway. Levocabastin is excreted mainly with the urine in unchanged form (about 70% of the absorbed amount). The half-life of levocabastine is about 35-40 hours.


Symptomatic therapy of seasonal and year-round allergic rhinitis.


Hypersensitivity to any of the components of the drug.

Children’s age up to 6 years.


Patients with impaired renal function and the elderly.


Reliable data on the use of nasal spray “Tizin ® Alergi” in pregnant women are not available. Therefore, Tizin ® Alergi nasal spray should not be used during pregnancy unless the intended benefit to the mother justifies the potential risk to the fetus.

Based on the determination of the concentration of levocabastin in the saliva and breast milk of lactating women who received 0.5 mg of levocabastin orally, it is expected that approximately 0.6% of the total intranasal dose of levocabastin can be passed to the baby during breastfeeding. Due to the limited number of clinical and experimental data, it is recommended to use caution when using nasal spray “Tizin ® Alerdzhi” in lactating women. If necessary, the appointment of the drug during lactation should stop breastfeeding.


Intranasally for adults and children over 6 years old, 2 doses (100 µg) in each nasal passage 2 times a day. Use of the drug should be continued until symptoms are eliminated.

In the case of severity of symptoms, you can apply 3-4 times a day. Patients should be warned about the need to release the nasal passages before using the spray and inhale through the nose during administration.

Before first use, remove the protective cap and repeatedly press the spray nozzle until a mist appears. The bottle is ready for further use.

Shake the bottle before each use. Drug inhale through the nose.

Allergy nasal spray


Often (>1/10), often (>1/100, 1/1000, 1/10000, ® Alergi.

The simultaneous use of CYP3A4 isoenzyme inhibitors ketoconazole or erythromycin did not affect the pharmacokinetics of levocabastine when administered nasally.

Possible local interactions with other nasal preparations have not been studied enough, with the exception of interaction with oxymetazoline, which can transiently decrease the absorption of levocabastine when administered nasally.

Allergy nasal spray


Nasal spray “Tizin ® Alerdzhi” in the recommended dose usually does not have a clinically pronounced sedative effect and does not reduce the speed of the reaction compared with placebo. In the case of drowsiness, you should not engage in potentially hazardous activities that require increased attention and speed of psychomotor reactions.


If the medicinal product has fallen into disrepair or the expiration date has expired – do not throw it into sewage or on the street! Put the medicine in the bag and put it in the trash. These measures will help protect the environment!

Spray nasal dosage 50 mcg / dose.

On 10 ml (100 doses) of a preparation in a bottle from high-density polyethylene with a spray and a protective cap from low-density polyethylene.

On 1 bottle with the application instruction in a cardboard pack.

Do not use the drug after the expiration date printed on the package.

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