Executives, Drug for smart students and entrepreneurs seeking a gold standard increase motivation, wakefulness and focus eventually finding yourself exploring Modafinil and Adderall.
Both drugs are used to treat patients with a diagnosis of narcolepsy and both produce a feeling of wakefulness to the user.
Both are also used in Treatment of ADHD and other cognitive disorders, Although only Adderall was approved by the FDA for this purpose during the time of Modafinil is prescribed by psychiatrists-label. Although these two drugs have some similar attributes and effects, there are distinctive differences between them.
In this article, We will compare Modafinil vs. Adderall to help understand their main differences.. In addition to comparing the beneficial effects of each of these drugs, the potential side effects and risks of addiction should also be compared.
History of Modafinil and Adderall
ModafinilA: Modafinil is a eugeroic (promoting wakefulness) compound that was first discovered in 1976. The discovery of this compound was due to testing on another related compound, Adrafinil.
Adrafinil was first developed by scientists at the Lafon laboratories of the French pharmaceutical company 1974. It was one of a series of benzhydryl sulfinyl compounds developed by neuroscience and experimental medicine professor Michel Jouvet.
During the test to determine the Adrafinil mechanism of action, Modafinil was discovered. Adrafinil is broken down in the liver in inactive modafinilic acid and active modafinil. Modafinil is committed to being the primary active compound in Adrafinil.
Modafinil was first tested in animal testing and was seen in motor activity and wakefulness. Because of these results, as well as previous human tests with Adrafinil, Modafinil was first tested in humans for the treatment of narcolepsy and sleep disorders.
Modafinil was approved as a drug for the treatment of narcolepsy in France in 1994, and in the United States in 1998. He was later approved by the FDA in the USA in 2003 for the treatment of shift work sleep disorders, and adjunct treatment for obstructive sleep apnea / hypopnea sleep.
Modafinil is classified as Schedule IV prescription drugs in the United States, and this is only for prescription drugs in many other countries around the world, including Canada, the United Kingdom, Australia, and New Zealand.
In 2001, Lafon was purchased by Cephalon Inc. Then in 2011, Cephalon was acquired by the Teva pharmaceutical industry. To this day, Working as a subsidiary of Teva, Cephalon still makes the original version of the most popular brand Modafinil, Provigil.
Adderall: Adderall is a drug that contains a combination amphetamine and two enantiomers amphetamine (A mirror image of a copy of the same compound), Levamphetamine and dextroamphetamine.
Amphetamine was first discovered by English scientist Lazar Edelyan in 1887. It was first synthesized and studied for pharmaceutical use in the United States in 1927. In 1929, researcher Gordon Alles introduced himself with physical and psychological effects to stimulate documentation of drugs.
Alles accepted his findings for the pharmaceutical company Smith, Kline, and French, and in 1934, the drug used in the nasal decongestant, called phenamine, was first presented on the basis of amphetamine. Later in 1937, they began to produce Dexedrine, which is made from only the more powerful amphetamine D-enantiomer.
How various formulations were used amphetamine and its derivatives stimulants and cognitive enhancers ever with. During World War II, amphetamine (Phenamine), and dextroamphetamine (Dexedrine) were given to soldiers and pilots to increase alertness and mood.
When first introduced in the 1930s, research on the effects of these drugs on the symptoms of attention deficit disorder (ADD) and attention deficit hyperactivity disorder (ADHD) in children showed a positive effect of these drugs had. Various formulations of amphetamines have been used as a medication for ADD and ADHD so far.
In the 1970s, Rexar Pharmaceutical Company reworked their Obertol weight loss drug by replacing two methamphetamine with the components amphetamine and dextroamphetamine. It has been sold for a number of years.
In 1994, Richwood Pharmaceuticals bought Rexar and they reuse this drug for treatment for ADD / ADHD, currently marketed as Adderall, which was the abbreviation of the phrase “Add for all.” Legal complications and disruption to production with the FDA led to a couple of years of controversy, but in 1996, Richwood was allowed to change the name, and Adderall had its status as an approved drug granted.
Rights to the drug have changed hands several times due to mergers and acquisitions of companies. In 2008, Teva Pharmacuticals bought Barr Pharmacueticals, which owned the rights of Adderall at the time, and to this day, Teva makes the brand version of Adderall.
Modafinil against. Adderall Effects
Comparison of Adderall vs.. Modafinil has not been conducted clinical studies. Therefore, we can only draw indirect conclusions about the differences between the work of these two drugs.
For both Modiginil (Provigil) and Adderall, exact mechanisms of action remain unknown. However, there are some very clear indications that the brain processes these drugs affect and the resulting effect they have on the user.
It is important to remember that many Nootropic drugs can affect people in different ways, depending on a number of different physiological factors.
Modafinil: Modafinil (Provigil, Modalert, Alertec, Modapro, Modiodal) works on several brain processes at the same time in order to create the desired stimulation. Scientists have suggested that this affects GABA, glutamate, histamine, and the neurotransmitters of norepinephrine, as well as the neuropeptide Orexin (Hypocretin).
The result is a natural feeling of being awake and alert. Other beneficial effects include increased motivation leading to increased productivity, minor mood elevation and general expansion ability to focus for long periods of time.
Adderall: Adderall works on Dopamine, Neurotransmitters norepinephrine and serotonin to produce a state of psychostimulation.
For those with ADD / ADHD, Adderall can produce a mental state. calm which allows the user to focus on tasks. For those who do not have ADD / ADHD, She tends to have a stimulating effect of type both mentally and physically.
Adderall is formed from a combination of four amphetamine and dextroamphetamine mixed salts: aspartate monohydrate, aspartate sulfate, dextroamphetamine sulfate, and dextroamphetamine saharaty.
It contains 25% levamphetamine salt (referring to the levorotary or left-handed enantiomer) and 75% dextroamphetamine salt (dextrorotary or right-handed enatiomer) per dose.