Furadonin – Antimicrobial synthetic therapeutic agent with a broad spectrum of action.
Furadonin is not an antibiotic, it belongs to the group of nitrofuran preparations. On many bacteria – Klebsiella, Staphylococcus, Enterococcus, E. coli, Proteus, Enterobacter, etc. – the drug has a bacteriostatic (stops the growth of microbes) and a bactericidal (kills germs) action.
Furadonin is used to treat urinary tract infections.
The drug is well absorbed from the gastrointestinal tract, passes through the placenta and into breast milk, cerebrospinal fluid, excreted by the kidneys. May give urine a dark color. Concentration in blood at usual therapeutic doses insignificant.
The active ingredient of the drug is nitrofurantoin.
Forms of release
- Tablets 0.05 g for 20 pieces per pack.
- Tablets 0.1 g for 20 pieces per pack.
- Tablets of 0.03 g soluble in the intestines of 30 pieces per pack (for children).
- Suspension Furadonin (for dispensing a measuring cup or spoon is attached in the package).
Instructions for use Furadonina
Indications for use
- Individual intolerance to nitrofurantoin;
- renal failure with severe impaired renal excretory function;
- chronic active hepatitis or cirrhosis of the liver;
- heart failure II-III degree;
- vitamin B deficiency;
- genetic (congenital) deficiency of the enzyme glucose-6-phosphate dehydrogenase;
- pregnancy and breastfeeding;
- early childhood: up to 1 month;
- acute porphyria (hereditary disease with damage to the nervous system);
- purulent inflammation of the kidney tissue.
- Allergic reactions:urticaria, angioedema (diffuse or limited swelling of the subcutaneous fat), pruritus; in very rare cases, anaphylactic shock (life-threatening severe allergic reaction of the body).
- On the part of the respiratory system:cough, shortness of breath, chest pain; interstitial pneumonitis (inflammation of the lung tissue with damage to the wall of the alveoli) or fibrosis (replacement of the lung tissue with connective tissue); decreased lung capacity; asthma attack in patients with bronchial asthma.
- On the part of the digestive system:loss of appetite, discomfort in the epigastric region, nausea, vomiting; in rare cases, hepatitis (inflammation of the liver); cholestatic jaundice (violation of the outflow of bile); abdominal pain, diarrhea.
- From the nervous system: headaches, drowsiness, dizziness, nystagmus (involuntary oscillatory rhythmic movements of the eyeballs), peripheral neuropathy (dystrophic lesion of peripheral nerves).
- From the side of blood-forming organs: a decrease in the number of leukocytes (white blood cells), a decrease in the number of platelets (blood plates involved in blood coagulation), a decrease or complete absence of granulocytes (a type of white blood cells involved in the body’s defense reactions), hemolytic anemia (anemia due to the destruction of red blood cells blood cells), megaloblastic anemia (malignant anemia with vitamin B deficiency12) – these adverse reactions are reversible.
- On the part of the skin: exfoliative dermatitis (inflammation of the skin with detachment of the surface layer), erythema multiforme (a disease of the skin and mucous membranes of an infectious-allergic nature).
- Other side effects options: superinfection of the urinary tract (inflammatory process caused by another pathogen – more often with pyocyanic stick); arthralgia (joint pain); drug fever; chills, aches in bones; weight loss; tinnitus; itching and vaginal discharge.
Furadonin has a bitter taste. Tablets should not be chewed; you need to drink them with plenty of water (at least 1 cup).
A bottle of suspension should be shaken well before use, then measure the required dose of medication. The suspension can be mixed with milk, water or fruit juice.
Taking Furadonin with food or milk can reduce the discomfort of the stomach and intestines.
The action of Furadonin is enhanced in an acidic environment, so the use of protein foods is recommended in the diet.
You should not take nalidixic acid and antacids (drugs that reduce the acidity of gastric juice) during treatment with Furadonin, which include magnesium trisilicate,
Sulfinpyrazon and Probenecid are also unsuitable for use at the same time – they help to reduce the excretion of Furadonin in the urine. And this will cause an increase in the concentration of Furadonin in the blood, an increase in its toxicity and a decrease in the therapeutic effect in the urinary tract.
Furadonine Dosage The dose of furadonin is determined by the doctor. Usually prescribed for adults 50-100 mg 4 times a day. The course of treatment lasts 5-8 days, if necessary, the doctor can extend the course of treatment up to 10 days.
In the absence of a therapeutic effect, a longer administration of the drug is not advisable.
Preventive, anti-relapse treatment can last 3-12 months. The daily dose is determined at the rate of 1-2 mg per 1 kg of patient weight. The prophylactic dose can be taken 1 time a day, before bedtime.
Furadonin for children
In pediatrics, for the treatment of urinary tract infections, Furadonine may be given to children older than 1 month of age.
The dose of the drug is determined at the rate of 5-7 mg per 1 kg of body weight per day. The daily dose is divided into 4 doses.
Children over 12 years old are prescribed 100 mg 2 times a day. The course of treatment is 5-7 days.
Furadonin during pregnancy
Experimental studies on animals revealed a risk to the fetus. The clinical experience of using Furadonin during pregnancy has not been studied.
Gynecologists sometimes use Furadonin in the treatment of urinary tract infections in women after 12 weeks of pregnancy. In this case, it is necessary to compare the possible risk to the fetus and the therapeutic effect of the use of Furadonine.
Furadonin for cystitis
Furadonin is used to treat acute and chronic cystitis (inflammation of the bladder) in both adults and children (older than 1 month).
It is advisable to conduct a bacteriological examination of urine (urine culture) prior to treatment to identify the causative agent that caused cystitis, and determine the sensitivity of the selected microorganism to antibacterial agents (and to Furadonin as well). In chronic cystitis, such an examination should be carried out with each exacerbation,
Furadonin dosage for cystitis is normal: 50-100 mg 4 times a day. Duration of treatment is 7-10 days. Children are prescribed a dose of 5-8 mg per 1 kg of body weight.
Maintenance dose (or prophylactic to prevent exacerbations) in chronic cystitis – 50-100 mg Furadonin 1 time per day (can be taken at night). The duration of maintenance therapy is determined by the doctor. Treatment can be carried out within 3-12 months. More about cystitis
There are no structural analogues (synonyms) for Furadonin.
Analogs on the mechanism of therapeutic action (nitrofuran derivatives):
Furagin or Furadonin?
Furadonin and Furagin are antimicrobials from the same group (nitrofuran derivatives). The mechanism of action and indications for these drugs are similar. In some cases, Furagin shows a more effective action.
Both of these drugs have almost the same side effects. But in Furagin they are somewhat less pronounced, it is a milder drug in comparison with Furadonin.
Currently, in the treatment of urinary tract infections are used more modern drugs (Norbaktin, Nolitsin, etc.). In any case, the choice of the drug is carried out by the doctor. Read more about the drug Furagin
Many reviewers have noted the rapid therapeutic effect of the use of Furadonin for cystitis. But there are reviews of its inefficiency, especially in the treatment of pyelonephritis.
Of the advantages of the drug note the relative cheapness of furadonin.
In almost all reviews, there are painful side effects, especially on the part of the digestive organs (nausea, vomiting, loss of appetite, abdominal pain) and the nervous system (headache, dizziness).
Many reviewers recommend taking more modern, new drugs, although they are more expensive.
50 mg Furadonin tablets – the price ranges from 33 to 75 rubles.
Furadonin tablets on 100 mg – the price from 85 to 108 rubles.