Vitamin with ascorbic acid

International name. Pyridoxine (Pyridoxin).

Vitamin with ascorbic acid

Composition and release form. Solution for injection, 1 ampoule with 1 ml of solution for injection contains 0.05 g, 0.1 g or 0.15 g of pyridoxine hydrochloride, in a carton 10 pcs.

  • pharmachologic effect
  • Indications for use
  • Contraindications
  • Side effects
  • Interactions with other drugs

Pharmachologic effect. Vitamin B6 (pyridoxine) regulates protein metabolism. This is due to his participation in the processes of transport of amino acids across cell membranes. Pyridoxine increases the content of creatinine in the striated musculature, which plays an important role in the process of muscle contraction. Takes part in fat and lipid metabolism, improves the absorption of unsaturated fatty acids. With a deficiency of vitamin B6 (pyridoxine), the activity of glucose-6-phosphate dehydrogenase, one of the direct oxidation enzymes of glucose in the pentose-phosphate cycle, decreases. Pyridoxal-5-phosphate is part of the phosphorylase that regulates the breakdown of glycogen. Significantly affects blood formation and immunity. Vitamin B6 (pyridoxine) synthesizes erythropoiesis, leukopoiesis and hemoglobin biosynthesis; activates cellular factors of nonspecific immunological

Vitamin with ascorbic acid

Indications for taking vitamin B6. Hypo-and avitaminosis B6 (treatment and prevention) – malnutrition, prolonged infections, diarrhea, enteritis, sprue, prolonged stress, malabsorption syndrome, condition after removal of the stomach and large intestinal sections, hemodialysis. As part of complex therapy: hypochromic and microcytic anemia, parkinsonism, sciatica, Little’s disease, Meniere’s disease and neuritis (in

Contraindications when using vitamin B6.

Side effects. Allergic reactions, hypersecretion of HCl, numbness, the appearance of a feeling of pressure in the extremities – a symptom of stockings and gloves, reduced lactation (sometimes it is used as a therapeutic effect); rarely, convulsions (occur only with rapid administration).

Dosing regimen. For the treatment of sideroblastic anemia, 100 mg is prescribed intramuscularly, 2 times a week. It is advisable to simultaneously take folic acid, cyanocobalamin, riboflavin. When parkinsonism – intramuscularly, 100 mg / day; for a course – 20-25 injections, repeat the treatment in 2-3 months or, starting with a dose of 50-100 mg / day, daily increase the dose by 50 mg, bringing it to 300-400 mg / day, in the form of a single injection in within 12-15 days. In depressions of the involutionary age – intramuscularly, at 200 mg / day. For the treatment of pyridoxine-dependent convulsive syndrome in adults – intravenously or intramuscularly, 30-600 mg; children – 10-100 mg daily.

Interaction with other drugs. Enhances the effect of diuretics; weakens the activity of levodopa. Isonicotine hydrazide, penicillamine, cycloserine, and estrogen-containing oral contraceptives reduce the effects of pyridoxine. It is well combined with cardiac glycosides (pyridoxine enhances the synthesis of contractile proteins in the myocardium), with glutamic acid and asparkam (increased resistance to hypoxia). Pharmaceutically incompatible with vitamins B1 and B12, in powder with ascorbic and nicotinic acids.

Storage conditions. Vitamin B6 (pyridoxine) should be stored in a dry, cool, out of reach of children, t ° not higher than + 25 ° C.

Manufacturer. WEIMER PHARMA, Germany.

The use of the drug vitamin B6 only as prescribed by a doctor, the instruction is given for reference!

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