Pharmacological properties of the drug Vitamin E
Vitamin E is a fat-soluble vitamin, has a pronounced antioxidant and radioprotective effect, is involved in the biosynthesis of heme and proteins, cell proliferation and other important processes of cellular metabolism. Vitamin E increases oxygen consumption by body tissues. It has an angioprotective effect, affects the tone and permeability of blood vessels, stimulates the formation of new capillaries. The immunomodulating effect of Vitamin E is manifested in the stimulation of T-cell and humoral immunity. Tocopherol is necessary for the normal course of reproductive processes: fertilization, fetal development, the formation and functioning of the reproductive system. With a deficiency of vitamin E, hypotension and dystrophy of skeletal muscles, myocardium develop, permeability and capillary fragility increase, and degeneration of photoreceptors develops, causing visual impairment. Men develop a decrease in sexual function, in women – menstrual disorders and a tendency to miscarriages. Vitamin E deficiency can cause hemolytic jaundice in newborns, malabsorption syndrome, steatorrhea. After absorption in the intestine, most of the tocopherol enters the lymph and blood, quickly distributed in the tissues of the body with a predominant accumulation in the liver, muscles, adipose tissue. The maximum concentration of the drug is determined in the adrenal glands, pituitary, gonads, myocardium. A significant part of the drug excreted in the urine, in part – with bile.
Indications for use of the drug Vitamin E
Hypovitaminosis E, menstrual disorders, threatened abortion; dysfunction of the male reproductive system; menopause; degenerative-dystrophic changes in the muscles (myopathy), joints, tendons; systemic connective tissue diseases (scleroderma, systemic lupus erythematosus, rheumatoid arthritis and others); skin diseases (dermatitis, psoriasis, trophic ulcers, eczema); eye diseases; recovery period after injuries, severe somatic diseases; during the period of increased physical activity; hypervitaminosis A and D; diseases that require antioxidant therapy.
Use of the drug Vitamin E
Adults and children aged 12 years old Vitamin E is administered orally after meals. In muscular dystrophy, diseases of the neuromuscular system, the tendon-articular apparatus – Vitamin E is prescribed in 100 mg 1-2 times a day. The course of treatment is 30–60 days, a second course is carried out in 2–3 months. With a violation of spermatogenesis and potency in men, the daily dose is 100-300 mg. In combination with hormonal therapy prescribed for 30 days. With the threat of miscarriage, Vitamin E is prescribed 100 mg 1–2 times a day for 7–14 days, and in the case of intrauterine fetal impairment, 100–200 mg / day in the first trimester of pregnancy. In the complex treatment of cardiovascular diseases, eye diseases, Vitamin E is prescribed 100–200 mg 1–2 times a day in combination with vitamin A. The course of treatment is 1–3 weeks. For dermatological diseases, the drug is prescribed 100-200 mg 1-2 times a day. The course of treatment is 20–40 days. For adults, a single dose is 100 mg, the maximum dose is 400 mg; the daily dose is 200 mg, the maximum daily dose is 1000 mg. In pediatric practice, Vitamin E at a dose of 100 mg can be used in children aged 12 years.
Contraindications to the use of the drug Vitamin E
Hypersensitivity to the drug components, marked cardiosclerosis, myocardial infarction. Children under the age of 12 years.
Side effects of the drug Vitamin E
Allergic reactions (itching, skin flushing). When taking the drug in high doses for a long time, hypocoagulation may occur, bleeding from the gastrointestinal tract, liver enlargement, creatinuria, fatigue, weakness, headache, nausea.
Special instructions for use of the drug Vitamin E
Be wary appointed with an increased risk of thromboembolism, patients with severe cardiosclerosis and myocardial infarction. When taking the drug, it is necessary to observe the dosage and duration of the course of treatment prescribed by the doctor, to prevent overdose and the development of hypervitaminosis E. With prolonged use of the drug in high doses, it is necessary to control the clotting time of the blood. Use during pregnancy and lactation. During these periods, apply only on prescription. Children. Vitamin E is not used in children aged ≤12 years. Influence on ability to drive vehicles and work with complex mechanisms. No data.
Drug interactions Vitamin E
Vitamin E can not be used in combination with iron, silver, alkaline agents (sodium bicarbonate, trisamine), indirect anticoagulants (dicoumarin, neodicoumarin). Vitamin E enhances the action of steroids and NSAIDs (sodium diclofenac, ibuprofen, prednisolone); reduces the toxic effect of cardiac glycosides (digoxin, digitoxin), vitamins A and D.
Overdose of Vitamin E, symptoms and treatment
When taking the drug in recommended doses, side effects do not develop. When taking the drug in high doses (400 mg / day for a long time), dyspeptic disorders, fatigue, general weakness, headache are possible; Creatinuria, an increase in the activity of creatine kinase, an increase in the concentration of cholesterol, TG, a decrease in the concentration of thyroxin and triiodothyronine in the blood serum, an increase in the concentration of estrogen and androgen in the urine. There is no specific antidote, the treatment is symptomatic.