Treatment of nodular goiter

Yodomarin ® 100

Registration number: П N013943 / 01 from

The composition of 1 tablet

Active ingredient: potassium iodide ?? 0.131 mg (which corresponds to 0.100 mg of iodine); excipients: lactose monohydrate ?? 75.119 mg, magnesium carbonate basic ?? 28,250 mg gelatin ?? 4,000 mg, sodium carboxymethyl starch ?? 4,750 mg, colloidal silicon dioxide ?? 1,750 mg, magnesium stearate ?? 1,000 mg.

Description: round flat-cylindrical tablets of white or almost white color, with a facet and a risky one side.

Pharmacotherapeutic group: thyroxine synthesis regulator ?? iodine drug

ATX code: H03CA.

Pharmacological properties

Iodine ?? vital trace element that ensures the normal functioning of the thyroid gland, the hormones of which perform many vital functions. They are responsible for the metabolism of proteins, fats, carbohydrates and energy in the body, regulate the activity of the brain, nervous and cardiovascular systems, the genital and mammary glands, as well as the growth and development of the child.

Iodine deficiency is especially dangerous for children, adolescents, pregnant women, and nursing women. Iodomarin ® 100 compensates for iodine deficiency in the body, preventing the development of iodine deficiency disorders and contributing to the normalization of thyroid function, impaired by iodine deficiency.

Indications for use

  • prevention of endemic goiter (especially in children, adolescents, pregnant and lactating women);
  • prevention of recurrence of goiter after its surgical removal or after the end of drug treatment with thyroid hormone drugs;
  • treatment of diffuse euthyroid goiter caused by iodine deficiency in children, adolescents and adults up to 40 years.


  • hyperthyroidism;
  • hypersensitivity to iodine;
  • toxic adenoma of the thyroid gland, nodular goiter when used in doses of more than 300 mg / day (with the exception of preoperative therapy to block the thyroid gland);
  • Herpetiformis (senile) dermatitis Dühring.

The drug should not be used for hypothyroidism, except in cases where the development of the latter is caused by a pronounced iodine deficiency.

The purpose of the drug should be avoided with radioactive iodine therapy, the presence or suspicion of thyroid cancer.

Use during pregnancy and lactation

During pregnancy and lactation, the need for iodine increases, so it is especially important to use in sufficient doses (200 µg / day) to ensure adequate iodine intake in the body. The drug penetrates through the placenta and is excreted in breast milk, so the use of the drug during pregnancy and lactation is possible only in recommended doses.

Dosage and administration

Goiter Prevention

Newborns and children up to 12 years old: ½ ?? 1 tablet Iodomarina ® 100 per day (which corresponds to 50−100 mcg of iodine).

Children over 12 years old and adults: 1-2 tablets of Iodomarin ® 100 per day (which corresponds to 100−200 mcg of iodine).

Period of pregnancy and lactation: 2 tablets Iodomarina ® 100 per day (which corresponds to 200 µg iodine).

Prevention of relapse of goiter

one ?? 2 tablets Iodomarina ® 100 per day (which corresponds to 100−200 µg iodine).

Treatment of euthyroid goiter

Newborns and children (from 1 year to 18 years): one ?? 2 tablets Iodomarina ® 100 per day (which corresponds to 100−200 µg iodine).

Adults under 40: 3-5 tablets of Iodomarin ® 100 per day (which corresponds to 300−500 µg iodine). The drug is taken after meals with a sufficient amount of liquid.

Children are advised to pre-dissolve the drug in milk or juice. Preventive reception is carried out within several years, in the presence of indications ?? for life

For the treatment of goiter in newborns, an average of 2–4 weeks is enough, in children, adolescents and adults it usually takes 6–12 months, and long-term administration is possible. The duration of treatment is determined by the attending physician.

Side effect

With prophylactic use at any age, as well as in the treatment of euthyroid goiter in newborns, children and adolescents, as a rule, no side effects are observed. In rare cases, the constant use of the drug can lead to the development of iodism, which can manifest a metallic taste in the mouth, swelling and inflammation of the mucous membranes (runny nose, conjunctivitis, bronchitis), iodine fever, iodine acne. Extremely rarely the development of angioedema, exfoliative dermatitis. When using the drug in a dose exceeding 150 µg / day, latent hyperthyroidism can turn into manifest form. With prolonged use of the drug in a dose exceeding 300 µg / day, it is possible to develop iodine-induced thyrotoxicosis (especially in elderly patients suffering from goiter for a long time, in the presence of nodular or diffuse toxic goiter).


Symptoms, staining of mucous membranes in brown, reflex vomiting (in the presence of food starch-containing components, vomit becomes blue), pain in the abdomen and diarrhea (perhaps melena). In severe cases, dehydration and shock may develop. In rare cases, there were stenoses of the esophagus, the emergence of the phenomenon of iodism (see Adverse effects).

Treatment of nodular goiter

Treatment for acute intoxication: washing the stomach with a solution of starch, protein or 5% sodium thiosulfate solution before removing all traces of iodine. Symptomatic therapy of violation of water balance, electrolyte balance, antishock therapy.

Treatment for chronic intoxication: drug withdrawal.

Treatment of iodine-induced hypothyroidism: the abolition of the drug, the normalization of metabolism using thyroid hormones.

Treatment of iodine-induced thyrotoxicosis: with mild forms of treatment is not required; in severe forms, thyrostatic therapy is required (the effect of which is always delayed). In severe cases (thyrotoxic crisis), intensive therapy, plasma exchange, or thyroidectomy are necessary.

Interaction with other drugs

Iodine deficiency increases, and excess iodine reduces the effectiveness of therapy for hyperthyroidism with thyrostatic agents. In this regard, before or during treatment of hyperthyroidism, it is recommended, if possible, to avoid taking any iodine. On the other hand, thyreostatic agents inhibit the transfer of iodine to an organic compound in the thyroid gland and, thus, can cause the formation of goiter.

Treatment of nodular goiter

Simultaneous treatment with high doses of iodine and lithium salts can contribute to goiter and hypothyroidism. High doses of the drug in combination with potassium-sparing diuretics can lead to hyperkalemia.

special instructions

Iodomarin ® 100 does not affect the ability to drive vehicles and control mechanisms.

Release form

Tablets 100 mcg. On 50 or 100 tablets in bottles of dark glass. On 1 bottle together with the application instruction in a cardboard pack.

Storage conditions

At a temperature not higher than 25 ° С. Keep out of the reach of children!

Shelf life

3 years. Do not apply after the expiration date.

Pharmacy sales terms

Manufacturing firm

Berlin-Chemie AG Tempelhofer Veg, 83 12347, Berlin, Germany or Menarini-von Hayden GmbH, Leipziger Strasse, 7−13, 01097, Dresden, Germany

Claim Address

123317, Moscow, Presnenskaya Embankment, Building 10, BC Embankment Tower, Block B. Tel: (495) 785−01−00 Fax: (495) 785−01−01

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