Proper liver function is an important condition for beauty and health of the whole body.
Among the factors that negatively affect the state of the liver, experts distinguish:
Often, damage to the liver cells (hepatocytes) is inflammation. Preparations containing glycyrrhizic acid (HA) and essential phospholipids (EF) can help in the fight against it.
Past clinical studies.
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- favorable safety profile;
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“The seat of the soul”, “mother of the heart”, “source of life beginning” – as soon as the liver was not called in antiquity. The first researchers found that what the liver has to the body is of great importance. Today, scientists have a rich arsenal of knowledge about the structure, functions and role of this gland, therefore
Where is the liver
The liver is the largest gland in the body. However, it plays a huge role in maintaining the metabolism in which the toxins are neutralized. Such involvement of the liver in various processes explains the great attention that is usually paid to maintaining its health.
The liver is located in the abdominal cavity under the diaphragm. It is located in the region of the right hypochondrium, and may contain up to 1800 grams, as well as in the stomach.
This fabric consists of large lobes. A lobule is a collection of liver cells that has the shape of a multifaceted prism. The lobules are literally entangled by a network of vessels and bile ducts. You have developed quite weakly. The cells of this gland are involved in the neutralization of toxins that come from the blood stream, as well as in the formation of other compounds necessary for the body.
The main functions of the liver are:
- Metabolism. In the liver, protein is cleaved to protein, the synthesis of the most important compounds, glycogen, which processes excess glucose and fat metabolism takes place (the liver is sometimes called the “fat depot”). In addition, the metabolism of vitamins and hormones occurs in the liver.
- Detoxification. As we mention, the detoxification of various toxins and bacteria occurs in the liver, and then the kidneys are eliminated.
- Synthesis. In this gland bile is synthesized, consisting of bile acids, pigments and cholesterol. Wishes to participate in the digestion of fats, the absorption of vitamins, stimulates intestinal peristalsis.
Causes of pathology
Thus, the normal metabolism (metabolism) in the body is impossible without the proper functioning of the liver. To avoid their development. The most dangerous are the following:
- Alcohol abuseIn the liver, the main metabolism of ethanol occurs – alcohol, which is produced in alcoholic beverages. With small amounts of alcohol consumption, liver cells manage to cope with their processor. If a reasonable dose is exceeded, ethanol is damage to the liver cells – fat accumulation (fatty hepatosis or fatty degeneration), inflammation (alcoholic hepatitis) and destruction. At the same time, excessive formation of connective tissue in the liver (fibrosis, and later cirrhosis and even cancer) occurs. A patient with alcoholic liver damage may suffer from weakness, a general decrease in tone and appetite, and indigestion. Gradually, these symptoms are aggravated, tachycardia, jaundice and others join it. Alcoholic liver disease may not cause any pain.
- MalnutritionResponsibilities for the exchange of fatty foods and reduce engine activity. As a result, fat begins to accumulate in the liver cells, causing their dystrophy (steatosis). This leads to the fact that the active formation of free radicals begins – particles that carry an electric charge and are dangerous to the cells. In the liver, foci of inflammation and necrosis are secreted, connective tissue grows, and as a result cirrhosis can develop. Malnutrition causes diseases such as non-alcoholic fatty disease, cirrhosis, and liver cancer.
- Violation of the rules of medication and the action of toxic substancesUncontrolled medication leads to an increased load on the liver, because it processes the main part of drugs. It is believed that the medicinal damage to the liver makes up to 10% of all side effects. Current toxins that may be dangerous to the liver. Substances that have a toxic effect, cause the destruction of cell membranes, lead to malfunction of hepatocytes (liver cells), can cause hepatitis and liver failure. Patients complain of pain in the liver, weakness, general malaise; jaundice may develop.
- Virus attackThe effect of viruses on the liver is dangerous in the first place the development of viral hepatitis. It is an inflammatory disease of the liver that can even be fatal. Often the disease is asymptomatic. Sometimes patients complain of indisposition, fever, pain in the right hypochondrium, jaundice. In case of severe hepatitis, liver tissue necrosis may begin.
Major Liver Diseases
These are too weak negative factors affecting its impact. In total there are about 50 pathologies of this gland, which were noted in the European Association for the Study of the Liver, about 30 million Europeans suffer from its chronic diseases.
Let us list again the main types of pathological changes in the liver:
- hepatosis (fatty liver, steatosis)
- liver failure;
- cancer and others.
Signs of malfunction of the gland and the diagnosis of diseases
Therefore, it is not always possible to make a definite conclusion that the patient is faced with a liver disease. Patients noted poor health, loss of appetite, lethargy, abnormal stool, frequent colds, increased susceptibility to allergic reactions, skin itching, irritability (toxins that are not neutralized in the liver, have a negative effect on the brain).
Among the specific signs of violation can be identified:
- pain in the right hypochondrium;
- appear heaviness, abdominal discomfort, nausea;
- bitterness in mouth.
The brightest sign indicating the presence of liver disease, of course, is jaundice – discoloration of the skin and mucous membranes. This is due to the accumulation of bilirubin in the blood.
Symptoms of the disease are not always specific, in the presence of these symptoms, you must be examined. Early diagnosis will help the doctor prescribe an effective treatment and restore liver function as much as possible.
The pathology is handled by a gastroenterologist. Blood therapy (ALT) (alanine aminotransferase), LDH (lactate dehydrogenase) and AST (aspartate aminotransferase). These indicators make it possible to judge the presence of inflammation in the liver. According to the content of other substances in the blood: GGT (gamma-glutamyl transpeptidase), bilirubin, alkaline phosphatase (alkaline phosphatase) – it is possible to judge the presence of stagnant bile.
Also, the patient must pass a urinalysis, as a result of which the bilirubin content is measured.
In relation to the liver, the doctor evaluates its size: in the presence of steatosis and inflammation of iron increases, and the tissues acquire a heterogeneous structure. Modern ultrasound diagnostic technology – elastography – makes it possible to measure the so-called elasticity of the liver tissue and to determine the degree of fibrosis. In addition, magnetic resonance or computed tomography may be used for diagnosis.
If the doctor needs to accurately establish the stage of the disease (for example, cirrhosis or fibrosis), a liver biopsy is performed – the tissue to be examined.
Liver disease prevention
One of the first steps towards maintaining liver health is diet control: the presence of large amounts of fatty foods, alcohol, fried and refined foods adversely affects the health of the gland. Cooking should not be plentiful, it is better to eat 4–5 times a day in moderate portions.
All these measures are effective, but not always sufficient. As a result, drugs can be obtained that help the liver and help restore the affected cells.
Drugs aimed at protecting and restoring the functions of the liver belong to the group of hepatoprotectors. In the framework of complex therapy, which involves a rational diet, an active lifestyle, giving up bad habits, the enemies prescribe various drugs to eliminate and restore the work of the hepatocytes.
Currently, there is a large selection of hepatoprotectors based on essential phospholipids – substances that are integral parts of cell membranes. The destruction of membrane hepatocytes (the development of the inflammatory process and other factors) leads to disruption of their work, the additional intake of phospholipids contributes to their recovery.
However, the search for a drug that causes the inflammatory process makes it impossible to repair the liver cells.
One of these substances is glycyrrhizic acid, which has anti-inflammatory, antioxidant and anti-fibrotic effects. In combination with phospholipids, the bioavailability of glycyrrhizic acid increases, which allows for the most pronounced therapeutic effects.
It should be noted that the complex composition of glycerol acids and phospholipids since 2010 is included in the list of vital and essential medicines that are subject to approval by the Government of the Russian Federation.
Studies of the properties of glycyrrhizic acid began in 1975, and clinical studies have proven its effectiveness against non-alcoholic fatty liver disease, alcohol and drug pathology of the liver, chronic hepatitis and other diseases. Experts note that they have long been used in hepatoprotectors. That is why the new generation of drugs have a complex composition, which allows us to achieve noticeable results in the prevention and treatment of liver pathologies.