Nosological classification (ICD-10)
Description of the dosage form
Round, biconvex tablets with a smooth surface, from red-orange to red in color, with a characteristic odor.
The drug VOBENZIM is a combination of natural enzymes of plant and animal origin. When entering the body, the enzymes are absorbed in the small intestine by resorption of intact molecules and, by binding to transport proteins of the blood, enter the bloodstream. In the future, the enzymes, migrating along the vascular bed and accumulating in the zone of the pathological process, have immunomodulating, anti-inflammatory, fibrinolytic, anti-edema, antiplatelet and secondary analgesic effect.
The drug VOBENZIM has a positive effect on the course of the inflammatory process, limits the pathological manifestations of autoimmune and immunocomplex processes, has a positive effect on the immunological reactivity of the organism. Stimulates and regulates the level of functional activity of monocyte macrophages, natural killer cells, stimulates antitumor immunity, cytotoxic T-lymphocytes, phagocytic activity of cells.
Under the influence of the drug VOBENZIM, the number of circulating immune complexes decreases and membrane deposits of immune complexes are removed from the tissues.
The drug VOBENZIM reduces the infiltration of the interstitium by plasma cells. Increases the elimination of protein detritus and fibrin deposits in the area of inflammation, accelerates the lysis of toxic metabolic products and necrotic tissue.
The drug VOBENZIM normalizes the permeability of the walls of blood vessels, contributes to a more rapid resorption of hematomas and edema.
The drug VOBENZIM reduces the concentration of thromboxane and platelet aggregation. It regulates the adhesion of blood cells, increases the ability of red blood cells to change their shape, adjusting their plasticity, normalizes the number of normal discocytes and reduces the total number of activated platelet forms, normalizes blood viscosity, reduces the total number of microaggregates,
The drug VOBENZIM reduces the severity of side effects associated with hormonal drugs (in
The drug VOBENZIM normalizes lipid metabolism, reduces the synthesis of endogenous Xc, increases the content of HDL, reduces the level of atherogenic lipids, improves the absorption of polyunsaturated fatty acids.
The drug VOBENZIM increases the concentration of antibiotics in the blood plasma and inflammation,
The drug VOBENZIM regulates the mechanisms of nonspecific protection (the production of interferons), thereby showing antiviral and antimicrobial action.
Indications drug Wobenzym
It is used in the treatment of the following diseases:
angiology – thrombophlebitis, postthrombotic disease and acute superficial vein thrombophlebitis, endarteritis and atherosclerosis obliterans of lower limb arteries, prevention of recurrent phlebitis, lymphatic edema;
urology – cystitis, cystopielitis, prostatitis, sexually transmitted infections;
gynecology – chronic infections of the genitals, adnexitis, gestosis, mastopathy;
cardiology – Angina, subacute stage of myocardial infarction (to improve the rheological properties of blood);
pulmonology – sinusitis, bronchitis, pneumonia;
gastroenterology – pancreatitis, hepatitis;
nephrology – pyelonephritis, glomerulonephritis;
endocrinology – diabetic angiopathy, diabetic retinopathy, autoimmune thyroiditis;
rheumatology – rheumatoid arthritis, reactive arthritis, ankylosing spondylitis;
dermatology – atopic dermatitis, acne;
surgery – prevention and treatment of postoperative complications (inflammation, thrombosis, edema), adhesive disease, post-traumatic and lymphatic edema, plastic and reconstructive surgery;
traumatology – injuries, fractures, distortion, damage to the ligaments, bruises, chronic post-traumatic processes, inflammation of soft tissues, burns, injuries in sports medicine;
neurology – multiple sclerosis;
pediatrics – atopic dermatitis, infectious and inflammatory diseases of the respiratory tract (inflammation of the upper and lower respiratory tract, pneumonia), juvenile rheumatoid arthritis, prevention and treatment of postoperative complications (suppuration and poor wound healing, formation of adhesions, local edema);
ophthalmology – uveitis, iridocyclitis, hemophthalmus, diabetic retinopathy, ophthalmosurgery.
Prevention of microcirculation disorders, post-stress disorders, as well as the breakdown of adaptation mechanisms.
Prevention of side effects of HRT, hormonal contraception. In surgical interventions to prevent infectious complications and adhesive disease.
The drug VOBENZIM recommended for the prevention of infectious complications and improve the quality of life during chemotherapy or radiation therapy.
Prevention of viral infections and their complications.
individual intolerance to individual components of the drug;
diseases associated with an increased likelihood of bleeding (hemophilia, thrombocytopenia);
children’s age up to 5 years.
Use during pregnancy and lactation
Pregnancy and lactation are not a contraindication for the use of the drug, but pregnant women should take the drug VOBENZIM under the supervision of a physician.
The drug VOBENZIM well tolerated by patients. In most cases, side effects, withdrawal syndrome, addiction was not observed even with prolonged treatment with high doses. In some cases, there are minor changes in the consistency and smell of feces, skin rash in the form of urticaria, which take place with a decrease in the dose of the drug or withdrawal.
If other adverse reactions that are not noted in the description appear, it is recommended to stop taking the drug and consult a doctor.
At the same time taking the drug with other drugs incompatibility cases are not described.
Dosage and administration
Inside no less than 30 minutes before a meal, without chewing, drinking water (200 ml).
Depending on the activity and severity of the disease, the drug VOBENZIM is taken in a dose of from 3 to 10 table. 3 times a day. In the first 3 days of taking the drug, the recommended dose is 3 table. 3 times a day.
With an average activity of the disease, the drug VOBENZIM is prescribed in a dose of 5-7 tablets. 3 times a day for 2 weeks. In the future, the dose of VOBANZIM should be reduced to 3-5 table. 3 times a day, the course – 2 weeks.
With a high disease activity, the drug VOBENZIM is prescribed in a dose of 7-10 tablets. 3 times a day for 2-3 weeks. In the future, the dose of VOBANZIM is reduced to 5 tab. 3 times a day, course – 2–3 months.
In chronic long-term current diseases, the drug VOBENZIM can be used according to indications in courses of 3 to 6 months or more.
In order to increase the effectiveness of antibiotics and prevent dysbacteriosis, the drug VOBENZIM should be used throughout the entire course of antibiotic therapy in a dose of 5 tab. 3 times a day. After stopping the course of antibiotics to restore the microflora (biocenosis) of the intestine, the drug VOBENZIM should be prescribed in 3 tab. 3 times a day for 2 weeks.
As a cover therapy during chemotherapy and radiation therapy, the drug VOBENZIM should be used in a dose of 5 tab. 3 times a day until completion of chemotherapy and radiation therapy; to prevent infectious complications, improve the tolerability of basic therapy and improve the quality of life.
When using the drug VOBENZIM prophylactic dose of the drug is 3 table. 3 times a day, a course of 1.5 months with a repetition of 2-3 times a year.
Children from 5 to 12 years old – 6 kg of baby weight 1 tab. per day; from the age of 12 – according to the scheme for adults
Dosage and duration of treatment depend on the severity of the disease and are determined by the doctor.
Cases of drug overdose are unknown.
In the case of infectious processes, the drug VOBENZIM does not replace antibiotics, but increases their effectiveness by increasing the concentration in the blood plasma and the focus of inflammation.
It should be borne in mind that at the very beginning of the drug, the symptoms of the disease may worsen, in such cases, treatment should not be interrupted, but a temporary reduction in the dose of the drug is recommended.
The drug is not doping.
Impact on the ability to drive vehicles and mechanisms.The drug does not adversely affect the ability to drive vehicles and perform work that requires a high rate of mental and physical reactions.
Enteric coated tablets. At 20 tab. in PVC / PE / PVDH / aluminum blister. 2, 5 or 10 bl. in a pack of cardboard.
800 tab. in a bottle of HDPE. 1 fl. in a pack of cardboard.
Mukos Emulsions GmbH, Germany. Miraustrasse 17, 13509 Berlin, Germany.
The name of the legal entity in whose name the registration certificate is issued: Mukos Pharma GmbH and Co., CG, Germany.
Information for consumer requests: for more information, contact the representative office of the company Mukos Pharma CZ (Czech Republic) in St. Petersburg. 191025, St. Petersburg, Nevsky Prospect, 114–116, lit. BUT.
Tel: (812) 315-95-85, (812) 315-92-95.
Tel .: (495) 231-27-31, (499) 240-02-74 (Moscow).
Pharmacy sales terms
Storage conditions of the drug Wobenzym
Keep out of the reach of children.
Shelf life of the drug Wobenzym
Do not use after the expiration date printed on the package.