Taking antihistamines aims to reduce itching in the affected areas of the skin. The drugs can significantly alleviate the condition of the patient with psoriasis during exacerbation of the disease.
The disease is difficult to treat
Psoriasis is a serious and currently difficult to treat disease. Since its inception, it gradually progresses, turning into a chronic stage. This does not mean that the disease does not respond to treatment at all – it can be kept in check for decades, approaching treatment in a complex and systemic way.
The effectiveness of treatment depends on the following factors:
- systematic use of drugs that block the unrestrained growth of immune cells in the skin tissues;
- conducting health and physiotherapy aimed at reducing the foci of the affected skin;
- during periods of exacerbation taking antihistamines;
- exclusion of factors that can lead to the progression of the disease: smoking, alcohol intake, stress;
- maintaining clean skin.
The complexity of the disease is clearly visible already in compliance with the last paragraph. Doctors know that the frequent use of soap can be a stimulus for the start of the next exacerbation and the appearance of itching. But the skin, with this disease – especially, must be clean and breathe well. Therefore, to avoid harm and solve the problem, hygiene issues are carefully discussed with the doctor.
Antihistamines used in psoriasis
Itching brings tremendous discomfort to the patient. He is one of the frequent satellites of this disease. Actually, the name of the disease itself is translated from Greek as pruritus. To cope with the painful burning of the skin allows, again, a set of measures – in the treatment of psoriasis, the emphasis on a single remedy is not welcome, only on the complex. Among the medicines prescribed by the doctor, antihistamines are not the last. What pills, and in what sequence the doctor decides to take, but it will not be superfluous for the patient himself to understand the variety of remedies for itching.
There is a division into groups by generations of drugs. In psoriasis, the doctor often prescribes at the same time both first-generation drugs and the newest third and fourth, recommending only a certain sequence of administration. The reason for such wide coverage of treatments is the addiction to certain pills and the need to increase or diversify their effects.
Antihistamine tablets, solutions for injection of the first generation have a pronounced sedative effect, therefore they are not suitable for patients whose occupation is connected with the need to concentrate attention. Drugs in this group well block the H1 receptors, but the bonds they form are easily replaced by histamine entering the tissues. This means that the antipruritic effect is short-lived, albeit fast. Therefore, funds included in this group are taken 2-3 times a day. After two or three weeks of administration, it becomes addictive, and the medicine is replaced by another, perhaps the same group or a newer one.
The most famous tablets of the first generation are: DIPHENHYDRAMINE (DIMEDROL), CLEMASTINE (TAVEGIL), CHLOROPYRAMINE (SUPRASTIN), MEBGIDROLIN (DIAZOLIN), DOXYLAMINE (DECAPRINE). In total, histamine blocking agents, which have been serving as a cure for itching and allergic manifestations for dozens of years, are now on the market for about two dozen items. Most similar drugs are found in pharmacies under different, duplicate, names. For example, Pheniramine is often on pharmacy shelves can be found under the name AVIL and so on.
One of the first in our country appeared DIPHENHYDRAMIN tablets, best known as DIMEDROL. It relieves the itching reasonably well, but it also acts as a sleeping pill. DIMEDROL is produced in the form of ointments, tablets, injection solutions. The presence of a liquid dosage form is often used for emergency care. However, DIMEDROL can have side effects that are difficult to predict. With the presence of equally effective means of the first generation of antiallergic, he often prefer to find a replacement. Most drugs can be used as local anesthetics. This effect is due to a decrease in their permeability of cell membranes for sodium ions. So, DIMEDROL is even stronger analgesic than novocaine.
When choosing remedies to relieve itching, the doctor more often suggests two types of pills: CHLOROPYRAMINE (SUPRASTIN) or CLEMASTIN (TAVEGIL). Both bring a good healing effect. Available in tablet form, and solutions for injection. By TAVEGILU in some patients there is marked hypersensitivity – it is prescribed with caution.
MEBGIDROLIN (DIAZOLIN) has a sedative property, like all first-generation antihistamine medicines. When taken together with hypnotics and sedatives can enhance their effect. Like SUPRASTIN, it is indicated for the treatment of children and is available in the appropriate dosage.
The treatment of the second generation does not have a sedative effect, but their reception is limited for people with problems in the work of the heart muscle, with signs of arrhythmia. Drugs of the second generation cause a longer effect on suppressing the activity of histamine, so their intake is limited once a day. The effect of second-generation drugs is achieved due to the high degree of metabolism of the active substance in them entering and slowing it out of the body.
To the second generation drugs include acrivastine (SEMPREKS) dimethindene (fenistil), loratadine (Claritin), ebastine (Kestin), astemizole (GISMANAL), terfenadine (BRONAL, GISTADIN) BAMIPIN (SOVENTOL) and others. Such products of this group as LEVOKABASTIN, AZELASTIN, BAMIPIN are produced not only in the form of tablets, but in the form of ointments.
Taking Acrivastin tablets (Semprex) does not lead to the accumulation of the active substance in the body, which makes it possible to apply a flexible schedule of administration.
DIMETINDEN, better known as FENYSTIL, is close to the first generation drugs in terms of its effect on the body, but it has a longer anesthetic effect and a less pronounced relaxing effect.
LORATADIN, or CLARITIN, is a very popular remedy among people with allergies. It does not lead to loss of attention, does not negatively affect the work of the heart muscle. Tablets effectively fight pain in psoriatic-affected areas of the skin.
3rd generation and newest medicines
As for antihistamines of the third and newest generations, when creating them, the aim was to eliminate the cardiotoxic effect, any influence on the activity of the cardiac muscle, which is observed in all drugs of the previous group. However, they are as active as metabolites, and produce a long healing effect. Among the well-known drugs today are the newest generation of CETHIRIZIN (ZIRTEK) and FEXOPHENADINE (TELFAST). Recently, Dezloratatin (Erius) has appeared in pharmacies.
TSETIRIZIN (ZIRTEK) and PEXOPHENADINE (TELFAST) practically do not accumulate in the body, they effectively counteract the connection of histamine with receptors and, accordingly, the occurrence of itching. In addition, ZIRTEK has an increased ability to penetrate the skin, which is why it is often used specifically for the pathologies of this organ.
DEZLORATADIN (ERIUS) suppresses the mechanism of histamine release, reduces edema and vascular permeability in places of skin pathologies. It does not affect the ability to concentrate, not cardiotoxic.
In men and women, the disease is different. In women, moderate to severe itching accompanies psoriasis 15.5% more often. Why there is a burning sensation in the skin, which is the cause of the response of the painful reaction of the body in places of pathological changes in the skin.
In most cases, itching occurs at the beginning of the process, at the time of relapse, and decreases with a transition of the disease to a stable stage. Another cause of burning of the skin is the use of irritating therapeutic agents: powders, lotions, ointments. The main thing in choosing the necessary means for the care of diseased skin is to find the least aggressive one. Moreover, the choice for psoriasis is always very individual. Sometimes, the affected skin areas become infected, leading to severe itching. Endocrine disorders can also cause painful burning in the endometrial tissue.
How antihistamine medicines work
To understand the mechanism of the active substance, which is part of the drugs, it is necessary to understand why it occurs.
In psoriasis, many fat cells form in the skin’s tissues, which are histamine stores. The nature of such an active cell attack today is not completely clear. Mast cells, like basophils, rush to where an immune (protective) response is required. Pathology of the skin in psoriasis is perceived by the body as a foreign infection. Fat cells release a huge amount of immune elements, including histamine. It increases the permeability of capillaries, causes swelling and contributes to blood stagnation in the tissue, which, on the one hand, blocks the development of infection, and on the other – causes itching in pathological foci, the development of which he himself promoted.
The burning effect of histamine action occurs when it binds to the special receptors H1, H2 and H3. Medicines, more precisely, the active substances included in them, are able to occupy free receptors and thereby prevent the binding of histamine with them.
In the first generation of antihistamine drugs, such connections are very fragile. The active substance can not replace the bound histamine, it only occupies free receptors. However, having a weak connection with them, it can be replaced by a more active histamine. In the means of the latest generations, such ties are already more stable. That is why the taking of such tablets as ERIUS or ZIRTEK is carried out once a day, unlike DIMEDROL or TAVEGIL, which should be taken two to three times a day to prolong the effect against burning in skin tissues.
Suppression of pain in the skin is accompanied by the reception of certain antidepressants. Such drugs of the tricyclic group, such as AMITRIPTILIN or CLOMIPRAMIN, not only improve night sleep, but also reduce the degree of skin burning during psoriasis.
The value of medicine for effective treatment
In the overwhelming majority of cases, the disease occurs in waves, with attenuation and activation of pathological processes occurring in the skin. If basic medicines, physiotherapy and phytotherapy, dosed UVC radiation should be taken continuously and systemically, the doctor sometimes prescribes antihistamines only when the first signs of relapse occur.
Itching for psoriasis is an aggravating phenomenon in the patient’s condition. The patient sometimes suffers so much from an unpleasant burning sensation in the skin that every minute being in this state deprives him of the will to live and, of course, complicates the treatment process.
Antihistamines, along with ointments and physiotherapy, can neutralize completely painful manifestations at the onset of relapse.
Summing up, we recall:
- drugs of different generations are effective;
- taken comprehensively, change with signs of addiction;
- have side properties: belonging to the first generation, have a sedative effect, the second – cardiotoxic;
- most come in pill form, but some can be presented in pharmacies in the form of injections or ointments.
The most important thing is that psoriasis is an insidious disease that almost always manifests itself as a relapse, so it is better to take any medication after consulting a specialist.