In this article, you can read the instructions for use of the drug. 5 noc. Presented reviews of visitors to the site – the consumers of this medicine, as well as the opinions of doctors of specialists on the use of 5 nok in their practice. A big request to add your feedback on the drug more actively: the medicine helped or did not help to get rid of the disease, what complications and side effects were observed, perhaps not stated by the manufacturer in the annotation. Analogs 5 nok in the presence of the available structural analogs. Use for the treatment of cystitis, pyelonephritis and other urinary tract infections in adults, children, as well as during pregnancy and breastfeeding.
5 noc – antimicrobial drug, 8-hydroxyquinoline derivative.
It has a wide spectrum of action. Selectively inhibits the synthesis of bacterial DNA, forms complexes with metal-containing microbial cell enzymes.
It is active against gram-positive and gram-negative bacteria, as well as other microorganisms: Ureaplasma urealyticum, Mycoplasma hominis, Mycobacterium tuberculosis, Trichomonas vaginalis. Effective against some species of fungi (candida, dermatophytes, mold fungi, some causative agents of deep mycoses).
Nitroxoline is well absorbed from the gastrointestinal tract (90%). Metabolized in the liver. Excreted mainly by the kidneys unchanged and partially with bile. There is a high concentration of conjugated and unconjugated drug in the urine.
Treatment of acute, chronic and recurrent urinary tract infections caused by microorganisms sensitive to nitroxoline:
- an infected prostate adenoma or carcinoma.
Prevention of infectious complications in the postoperative period during surgical interventions on the kidneys and urinary tract, as well as diagnostic and therapeutic procedures (catheterization, cystoscopy).
Prevention of recurrent urinary tract infections.
Forms of release
50 mg coated tablets.
Instructions for use and dosing regimen
The standard dose for adults and adolescents is 400 mg per day, divided into 4 doses (2 tablets, 4 times a day). The maximum dose is 800 mg per day.
The average dose for children older than 5 years is 200-400 mg per day, divided into 4 doses; for children 3-5 years old – 200 mg per day, divided into 4 doses.
The course of treatment is 2-4 weeks, if necessary, the therapy is continued with intermittent courses (2 weeks during the month).
Patients with moderate renal insufficiency (QC more than 20 ml / min) and liver failure are recommended to use half of the standard daily dose of the drug – 200 mg per day (1 tablet 4 times a day).
Tablets should be taken before meals.
- nausea, vomiting (can be prevented by taking the drug during meals);
- paresthesia, polyneuropathy;
- skin rash;
- severe renal failure (CC less than 20 ml / min);
- severe liver failure;
- children up to 3 years;
- lactation period (breastfeeding);
- hypersensitivity to nitroxoline or other components of the drug;
- hypersensitivity to quinolines.
Use during pregnancy and lactation
The drug is contraindicated for use during pregnancy and lactation (breastfeeding).
Use in children
5 NOK is contraindicated in children under 3 years of age.
Nitroxoline should not be administered simultaneously with drugs containing hydroxyquinolines or their derivatives.
You should not assign treatment for more than 4 weeks without additional examination of the liver and kidneys.
During treatment with nitroxoline, urine is stained an intense yellow-red color.
Influence on ability to drive motor transport and control mechanisms
There is no data on the effect on the ability to drive a car or machinery.
Analogs of the drug 5 NOK
Structural analogues of the active substance: