For women with a uterine version of infertility, when the inner surface of the uterus is unable to receive a fertilized egg, it is extremely important to use effective therapies. Longiditis with endometritis helps prevent endometrial adhesive disease, which is the basis for the thinning of the functional layer of the mucous membrane of the uterus and the formation of synechias. A necessary condition for successful treatment is the use of the original drug in the dosage prescribed by the doctor and with the optimal duration of the treatment course.
Combined therapy of chronic inflammation
At the first stage of treatment of a long-term inflammatory process in the uterus, antimicrobial therapy is necessarily carried out, for which a drug with optimal sensitivity to the identified microorganisms is selected. Only after that the following types of therapeutic effects are applied:
- hormone therapy for the correction of ovarian functions and the restoration of the structure of the endometrium;
- metabolic therapy, providing restorative processes of the mucous membrane of the uterus;
- vascular treatment to improve uterine artery blood flow;
- local immunocorrection in the endometrium;
- anti-fibrotic and anti-adherent therapy that prevents the formation of intracavitary synechiae;
In chronic endometritis, longidase provides an optimal anti-sclerotic and anti-fibrosis effect on endometrial tissue, therefore the drug is widely used in gynecology.
Medicinal properties of Longidase
Enzyme drug in the form of vaginal or rectal suppositories has many beneficial properties that will help the doctor cope with the effects of endometritis. The optimal therapeutic effect is provided by the following properties:
- antifibrous (preventing the formation of new fibrous adhesions);
- antisclerotic (reduction of the severity of sclerotic processes in the endometrium);
- anti-inflammatory (reduced inflammatory tissue response);
- decongestant (elimination of local tissue edema caused by chronic inflammation);
- antioxidant (prevents the destruction of endometrial cells);
- immunocorrective (improvement of local immune responses).
The versatility of the positive effects of candles helps prevent serious complications of the chronic inflammatory process – infertility and pelvic pain syndrome caused by adhesive disease.
Indications for use
The doctor will prescribe vaginal suppositories for Longidase in the following cases:
- chronic inflammation in the uterus with a lesion of the basal layer of the endometrium;
- identification with ultrasound scanning of intrauterine synechiae;
- infertility due to uterine or tubal-peritoneal adhesions;
- adhesive pelvic disease;
- prevention of adhesions after gynecological operations and interventions (artificial or spontaneous abortion, ectopic pregnancy, ovarian apoplexy, diagnostic or surgical operations).
Blood and inflammation are the main adhesions factors, therefore, in all cases when there is an infection in the abdominal cavity and organs of the small pelvis or blood enters in any quantity, it is necessary after the course of treatment to use the anti-adhesive treatment scheme.
Contraindications and side effects
The optimal treatment regimen includes Longidase, but we must remember about the possibility of contraindications, which include:
- pregnancy on any term of gestation;
- postpartum lactation;
- a child under 12 years old;
- in the presence of chronic renal failure;
- against the background of any malignant neoplasms;
- with a proven allergy to the drug.
With the observance of the treatment regimen and the therapeutic dose of the medicinal substance, the risk of negative impact on the woman’s body is minimal.
The standard method of treatment of chronic endometritis with suppositories with proteolytic activity implies vaginal administration of the drug overnight every other day. It is necessary to take the drug at least 10 times: the duration of therapy is stretched for 20 days.
One of the treatment options may be the appointment of intravaginal candles 1 time in 3 days with a course of 1 month. If necessary, the doctor will advise the continuation of treatment in the form of maintenance therapy on 1 candle 1 time per week.
It is unacceptable to try to use the drug 1 time per day: highly active drug substance can not be used without a doctor’s prescription and using a daily treatment regimen.
A course of treatment of chronic endometritis, arising after an abortion or against the background of a genital infection, necessarily includes a whole range of effective drugs. Immunomodulatory and anti-adherent candles reduce the risk of long-term complications and help prevent the formation of adhesions in the uterus. It is especially important to use Longidase in the complex treatment of uterine or tubal-peritoneal forms of infertility when a woman cannot find the happiness of motherhood for a long time.