Ceftriaxone is a third-generation antibiotic of the cephalosporic series with a broad bactericidal spectrum of action.
Differs in resistance in relation to the majority of beta-lactamases produced by microorganisms.
Preparty is not only not absorbed from the gastric mucosa, but also causes severe irritation. Therefore, the drug is available in powder form for the / m and / in the introduction.
This has its advantages:
- the drug enters the bloodstream faster, and, consequently, the therapeutic effect begins earlier;
- the bioavailability of the antibiotic is 100%, as it enters the bloodstream, bypassing the barrier function of the liver and avoiding destruction by digestive enzymes.
Compared with other cephalosporins, ceftriaxone binds well with blood proteins, with the result that it has a rather long half-life, and it is enough to inject the drug 1-2 times a day.
The drug is active against gram-positive and gram-negative aerobes and anaerobes, with the exception of methicillin-resistant staphylococci, the majority of group D streptococci and enterococci.
The drug is included in the treatment of diseases of the urogenital system, among them pyelonephritis, cystitis, gonorrhea, prostatitis, epididymitis, syphilis, and chancroid.
However, in any case, before prescribing a drug, it is necessary to determine the sensitivity of microorganisms to it.
Usually the drug is well tolerated, there are not many contraindications, it is possible to use in pediatrics and during pregnancy, starting from the second trimester.
Of the drawbacks, the soreness at the injection site can be abolished in order to reduce its medication diluted with lidocaine.
In addition, the antibiotic inhibits the growth not only of pathogenic microorganisms, but also of normal flora, among which are bacteria responsible for the synthesis of vitamin K, which increases the risk of bleeding, especially in the elderly.
If it is necessary to replace
If necessary, the drug can be replaced with similar drugs, analyze what is better – Ceftriaxone or its analogues: Cefotaxime, Rocefin, Cefazolin, Azolin and some others.
Rocephin – Swiss quality and price
A Swiss drug whose active substance is ceftriaxone disodium salt.
Available in the form of a concentrated powder for parenteral use. Dosage forms intended for i / m administration are sold together with the solvent: lidocaine. Indications for use are the same as in Ceftriaxone.
Rocephin differs only in the fact that the dosage form for i / m use is available immediately with lidocaine, you do not need to buy it additionally.
The Swiss drug is better purified, its only minus is the high price. Some patients, reading the instructions to Rocephin, note that he has more side effects than Ceftriaxone.
In fact, this is not the case; just the majority of foreign manufacturers indicate in the annotation all the undesirable effects that were observed while taking the drug, while domestic manufacturers describe only the main ones.
Hazaran – high quality and expensive
Hazaran Yugoslav drug, the active ingredient of which is Ceftriaxone.
Therefore, the spectrum of action, indications and contraindications to the use of it are similar.
Both drugs contain the same substance, therefore, they have the same spectrum of action. The difference is in the degree of cleaning and price (imported equipment is more expensive).
Unfortunately, sometimes domestic manufacturers buy the substance for the manufacture of medicines abroad, but this one which already has expired and is sold much cheaper, which can not but affect the quality of the drug.
Cefotaxime also belongs to the third generation cephalosporins, its spectrum of action is almost the same as that of ceftriaxone.
It is poorly absorbed from the gastrointestinal tract, therefore the drug is used only parenterally.
The difference in cefotaxime is that it binds worse to blood proteins, and therefore is eliminated from the body after 6-8 hours.
Both drugs cause the death of the same microorganisms, the only difference is that Cefotaxime is also active in relation to methicillin-susceptible Staphylococcus aureus.
It is also faster excreted from the body, so in severe cases, the multiplicity of the introduction increased to 3-4 times per day.
And besides, the drug does not displace bilirubin from the connection with albumin, so it is recommended to use it for the treatment of newborns.
For the price, both drugs are not very different.
Cefazolin: pros and cons
Cefazolin belongs to the first generation cephalosporins, has a bactericidal effect. Available in powder form for the / m and / in.
When administered parenterally, it is rapidly absorbed into the blood. Up to 90% of the active substance is bound to plasma proteins, therefore the half-life is 8-12 hours.
Excreted mainly through the kidneys, creating in the urine large concentrations of the active substance.
Therefore, it is successfully used to treat the organs of the genitourinary system, including:
Cefalosin, as well as all the first generation cephalosporin antibiotics of the first generation, have low activity against gram-negative bacteria.
Ceftriaxone has a wider spectrum of action with respect to Gram-negative strains. However, Cefazolin is the drug of choice during lactation and does not require the abolition of breastfeeding.
Ceftriaxone is excreted both in urine and bile, so if the excretory function of the kidneys is impaired, but the liver is healthy, then no dose adjustment is required. Cefazolin also in violation of clearance requires a reduction in dosage.
Cefalexin – there are more pluses than minuses
Cephalexin belongs to the first generation of antibiotics of the cephalosporin series.
Available in the form of capsules and suspensions for oral administration. When taken orally, it is quickly absorbed from the gastrointestinal tract, the maximum concentration in the blood is observed after an hour.
Evenly distributed throughout the body, a high concentration of the drug is observed in the liver and kidneys.
Excreted from the body after 6 hours, if the kidney function is impaired, then this time increases many times.
Cefalexin already has a spectrum of action with respect to gram-negative microorganisms than ceftriaxone.
Of the benefits can be noted oral intake, no need to resort to the help of outsiders. Release capsules for adults and suspension for children.
Combined antibiotic Amoxiclav
Amoxiclav combined penicillin antibiotic. Active ingredient amoxicillin and clauvanic acid.
This combination was invented in the late 70s of the twentieth century. Both substances are well absorbed from the gastrointestinal tract, so the drug is produced in dosage forms for enteral and parenteral use.
Oral forms are represented by tablets and granules for the preparation of suspensions.
By itself, amoxicillin is destroyed by beta-lactamases, which produce some bacteria.
Clavunic acid inhibits a number of beta-lactamases, thereby preventing inactivation of amoxicillin.
In addition, it also has its own antibacterial activity, which significantly expands the spectrum of action of the drug.
Amoxiclav is successfully used to treat such urogenital diseases as:
- urinary tract infection;
- inflammation of the prostate gland;
- postpartum sepsis;
- bacterial vaginosis;
- tubo-ovarian abscess;
- septic abortion;
During treatment, it is necessary to control the work of the liver, kidneys and blood-forming organs.
Both drugs have a broad spectrum of action.
Amoxiclav has release forms for enteral use, which is very convenient, because not everyone can give injections. Also, the drug is available in ampoules, but it can only be administered in the form of infusions or meleno IV.
From the advantages it can be noted that the drug is quite widely used to treat women during pregnancy and no consequences for the fetus have been found.
It is impossible to say which drug is best. First, before treatment, it is necessary to determine the sensitivity of microorganisms to antibiotics and only then prescribe a specific medicine.
Secondly, it is not known what will be the reaction of the patient’s body to a particular drug, sometimes even the same active ingredient, but produced under different trade names may have different side effects.
In any case, self-medication is not acceptable, the doctor must select an antibiotic!