Blood test for antibiotics

Biseptol is a fully synthesized combined agent that has an antimicrobial effect and contains co-trimoxazole.

Blood test for antibiotics

The latter belongs to the group of sulfonamides, which are the first systemic antimicrobial agents.

On this page you will find all the information about Biseptol: complete instructions for use for this drug, average prices in pharmacies, complete and incomplete analogues of the drug, as well as reviews of people who have already used Biseptol. Want to leave your opinion? Please write in the comments.

Clinico-pharmacological group

Antibacterial sulfa drug.

Blood test for antibiotics

Pharmacy sales terms

It is released on prescription.

How much does Biseptol cost? The average price in pharmacies is at 40 rubles.

Release form and composition

The substance that provides Biseptolu therapeutic effect, called co-trimoxazole. This name combines two active compounds, the ratio of which in one tablet is 5 to 1. Depending on the number of such active substances, the preparation is represented by two dosages:

  1. 120 mg tablets, in which there is 100 mg of sulfamethoxazole, supplemented with 20 mg of trimethoprim.
  2. 480 mg tablets, of which the patient receives sulfamethoxazole in the amount of 400 mg, and trimethoprim in the dose of 80 mg.

Biseptol tablets are distinguished by a round flat shape, white (sometimes yellow) color, and the presence of risks and Bs engraving. They are packaged in blisters of 20 pieces and sold for 1 blister in a pack.

Pharmacological effect

Biseptol (480, 120, and 240 mg) is a broad-spectrum antimicrobial drug that refers to sulfanilamide drugs. The combination of active substances prevents the synthesis of folic acid, which is responsible for metabolic processes in microbial cells, as well as their division.

Blood test for antibiotics

Co-trimoxazole does not kill the causative agents of various diseases, but limits their reproduction, giving the immune system the ability to cope with pathogens on its own. This explains the absence of a strong toxic effect during Biseptol treatment.

The drug is able to cope with approximately 40 types of pathogenic microorganisms, including streptococcal and staphylococcal infections, Vibrio cholerae, Toxoplasma, Salmonella, Chlamydia, E. coli and others. Anaerobic and mycobacteria, as well as viruses, the drug has no effect.

It is also used for primary and secondary prevention of pneumocystosis and toxoplasmosis in HIV carriers.

Indications for use

According to the manufacturer’s instructions, Biseptol is prescribed for the treatment of infectious and inflammatory diseases, which are caused by microorganisms sensitive to the drug, namely:

  • Gonorrhea;
  • Otitis, sinusitis;
  • Infections of soft tissues and skin, including pyoderma, furunculosis;
  • Infections of the genitourinary system, including urethritis, pyelonephritis, prostatitis, salpingitis;
  • Various respiratory tract infections, including pneumonia, bronchitis, lung abscess, pleural empyema;
  • Infections of the gastrointestinal tract, including abdominal paratyphoid fever, typhoid, bacterial cholera, dysentery, diarrhea.

Biseptol is an antibiotic or not?

According to the abstract, Biseptol is not an antibiotic. It is a bactericidal drug (it causes the death of a microbial cell), but it does not apply to antibiotics. The action of the drug due to the fact that it blocks the synthesis of folic acid, without which the microbial cell can not divide. Sulfamethoxazole and trimethoprim complement and reinforce each other in this mechanism.

Contraindications

  • severe renal dysfunction in the absence of the ability to control the concentration of the drug in the blood plasma;
  • hyperbilirubinemia in children;
  • severe blood diseases;
  • deficiency of glucose-6-phosphate dehydrogenase;
  • established damage to the liver parenchyma;
  • severe renal failure;
  • hypersensitivity to the components of the drug, as well as to sulfonamides.

Biseptol should not be taken by women during pregnancy and lactation.

Children do not prescribe the drug:

  • pills – up to 3 years;
  • suspension – up to 2 months (or up to 1.5 months if the child was born from a mother with HIV infection).

Caution requires the use of Biseptol in the presence of the following diseases:

  • bronchial asthma;
  • lack of folic acid in the body;
  • thyroid disease.

Use during pregnancy and lactation

In pregnancy, the drug should be prescribed only if the expected benefit from its use exceeds the possible risk to the fetus, because both trimethoprim and sulfamethoxazole penetrate the placental barrier and, thus, can affect folic acid metabolism. In late pregnancy, the use of the drug should be avoided due to the possible risk of developing nuclear jaundice in newborns.

Due to the fact that trimethoprim and sulfamethoxazole penetrate into breast milk, the use of co-trimaxosol during lactation is contraindicated.

Instructions for use

The instructions for use indicate that the dosage of Biseptol is set individually depending on the disease. The drug is taken after meals with a sufficient amount of liquid.

  1. Children aged 3 to 5 years, the drug is prescribed 240 mg (2 tab. 120 mg) 2 times / day; children aged 6 to 12 years old – 480 mg each (4 tablets of 120 mg or 1 tablet of 480 mg) 2 times / day.
  2. Adults and children over 12 years old are prescribed 960 mg 2 times / day, with long-term therapy, 480 mg 2 times / day.
  3. Duration of treatment is from 5 to 14 days. In severe cases of the disease and / or in chronic infections, a single dose may increase by 30-50%.

With the duration of the course of therapy for more than 5 days and / or increasing the dose of the drug, it is necessary to monitor the peripheral blood picture; when pathological changes occur, folic acid should be administered at a dose of 5–10 mg / day.

  • In pneumonia, the drug is prescribed at the rate of 100 mg of sulfamethoxazole per 1 kg of body weight / day. The interval between doses is 6 hours, the duration of treatment is 14 days.
  • In gonorrhea, the dose of the drug is 2 g (in terms of sulfamethoxazole) 2 times / day with an interval between doses of 12 hours.

In patients with renal insufficiency with CC 15-30 ml / min, the standard dose of Biseptol should be reduced by 50%.

Side effects

Patients may experience the following side effects when treating Biseptolum:

  1. Urinary tract: tubulointerstitial nephritis, elevated creatinine, salt diathesis,
  2. Metabolism: Biseptol should be taken with caution in violation of potassium metabolism;
  3. Gastrointestinal tract: hepatitis, abnormal stool (diarrhea), cholestatic syndrome, glossitis, elevated levels of liver enzymes, in patients with severe chronic diseases and immune diseases, acute pancreatitis is often diagnosed;
  4. Skin reactions, which often disappear after drug withdrawal: an increase in the body’s sensitivity to the effects of ultraviolet light, polymorphic erythema, malignant exudative erythema, acute or toxic epidermal necrolysis, hemorrhagic vasculitis;
  5. Central nervous system: meningeal syndrome, impaired motor coordination, hallucinatory conditions;
  6. Musculoskeletal system: muscle and joint pain;
  7. Changes in the blood picture: a decrease in the level of leukocytes in the general cellular composition of the blood, a decrease in the number of neutrophils, a reduced platelet count, neutropenia, a deficiency of folic acid, aplastic anemia, an increase in the concentration of methemoglobin, Verlgof disease.

In patients with diabetes mellitus, in the first days of therapy there is a decrease in the concentration of glucose in the blood. Hypoglycemia also occurs in individuals with kidney and liver disease. The cause of this pathological condition may be inadequate nutrition.

Overdose

With a significant excess of the recommended therapeutic dose develop symptoms of acute poisoning – nausea, vomiting, abdominal pain, headache, impaired consciousness. In this case, the drug should be stopped and seek medical help.

Detoxification therapy includes gastric and intestinal lavage and symptomatic therapy. Chronic overdose can lead to the suppression of blood formation with a significant decrease in the number of all blood cells.

special instructions

Requires regular monitoring of the concentration of sulfamethoxazole in the blood. If the value is more than 150 µg / ml, the treatment is stopped until the value reaches 120 µg / ml and below. If the course of treatment is designed for a month or more, then regular monitoring of the blood condition is required.

Upon appointment folic acid hematologic changes are reversible. In AIDS patients, side effects are more common and are pronounced. Biseptol is not recommended when pharyngitis and tonsillitis caused by beta-hemolytic streptococ. BUT.

Drug interaction

  1. Derivatives of salicylic acid increase the effect of Biseptol.
  2. Sulfamethoxazole and trimethoprim increase the anticoagulant activity of indirect anticoagulants, as well as the action of hypoglycemic drugs and methotrexate.
  3. In combination with thiazide diuretics there is a risk of thrombocytopenia and bleeding.
  4. In combination with diuretics increases the risk of thrombocytopenia.
  5. Biseptol reduces the intensity of the hepatic metabolism of phenytoin and warfarin, enhancing their action.
  6. Phenytoin, barbiturates, PAS increase the manifestations of folic acid deficiency in combination with Biseptol.
  7. Benzocaine, procainum, procainamide (as well as other drugs, as a result of the hydrolysis of which PABK is formed) reduce the effectiveness of the drug Biseptol®.
  8. Ascorbic acid, hexamethylenetetramine increase the risk of crystalluria when taking Biseptol.
  9. Biseptol may increase the content of digoxin in the blood plasma in some elderly patients.
  10. In combination with drugs that inhibit bone marrow hematopoiesis, the risk of myelosuppression increases.
  11. Biseptol reduces the effectiveness of oral contraceptive drugs.

We picked up some reviews of people about the drug Biseptol:

  1. Olga I consider “Biseptol” an old, reliable, proven drug that helps in solving the problems of not only the sick respiratory organs, but also of ulcers, barley, and diarrhea. She treated herself and her children with success. I know that it is bad for the liver, because it consumed it only after eating and drinking milk. In the battle with broncho-pulmonary diseases, it is obligatory to take 4 tablets per day, 2 times with an equal interval within 3-5 days, depending on the severity. For ulcers, one or two single intakes of 2 tablets are sufficient, and it saves diarrhea from one administration in the same number of tablets. Wonderful drug!
  2. Tatyana . That’s right, if dogs are treated, it means a person

Analogs are drugs: Bakteptol, Bactrim, Biseptazole, Biseptrim, Groseptol, Co-Trimoxazole, Oriprim, Raseptol, Soluceptole, Sumetrolim, Triseptol.

Before using analogues consult your doctor.

Storage conditions and shelf life

Biseptol is an antibacterial drug whose sales from pharmacies are allowed only for medical purposes. The shelf life of Biseptol tablets and Biseptol 480 when necessary storage conditions are observed is 5 years, suspensions are 3 years.

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