About the drug:
Retinol Acetate, or Vitamin A, is a fat-soluble vitamin that is actively involved in the metabolic process. It is necessary for the body for normal full growth and maintain visual function. Vitamin A has a stimulating effect on the body’s regenerative and epithelial processes and improves the nonspecific immune response. Retinol also plays a large role in the formation and maintenance of the body’s resistance to adverse environmental conditions.
Indications and dosage:
The use of the drug Retinol acetate is usually prescribed for the treatment of:
Hypovitaminosis and avitaminosis A
Various corneal lesions and eczematous eyelid lesions
As an element of complex therapy, Retinol acetate is also used in the treatment of:
Acute diseases of the lungs and bronchi
Skin lesions (in this case, Retinol Acetate is used to enhance the regenerative functions of the body and stimulate epithelialization).
In addition, Retinol acetate is indicated for use in respiratory diseases that occur on the background of exudative diathesis.
Retinol Acetate – an oily solution for topical or oral administration.
In the treatment of avitaminosis A, 1-2 drops are usually prescribed twice a day. Orally 15 minutes after meals.
For the treatment of diseases of the skin is usually prescribed for 5-10 drops twice a day orally (appointed in conjunction with preparations of vitamins B).
Locally Retinol acetate is used for skin lesions. It is recommended to apply a gauze bandage up to 6 times a day.
Children over 7 years old are usually given 1-2 drops orally.
It should be remembered that the maximum permissible single dose of the drug for adults is 10 drops of the solution (50000ME), for children from 7 years old – 1 drop.
The maximum daily dose of Retinol acetate for adults is 20 drops of the solution (100,000 ME).
The maximum daily dose of Retinol acetate for children over 7 years old is 4 drops of the solution (20000ME).
The use of a dose of Retinol acetate, which is much higher than the recommended, can lead to an overdose of vitamin A, the symptoms of overdose are ataxia, drowsiness, headache, vomiting, nausea, pain in the bones of the lower extremities. In the event of an overdose of the drug, its use should be immediately stopped and go to a doctor. Since there is no specific antidote to Retinol acetate, symptomatic treatment is recommended. Laxatives are effective in treating overdose with this drug. Forced diuresis is recommended.
As a rule, the use of Retinol acetate is not accompanied by side effects, the drug is well tolerated by the body. But in rare cases, an allergic reaction may occur, accompanied by skin manifestations characteristic of it. The use of this drug over a long period of time in high doses can lead to the development of chronic overdose of vitamin A (hypervitaminosis A).
Symptoms of hypervitaminosis A are:
Exanthema and oliguria.
In case of detection of these symptoms, you should immediately stop taking the drug and consult a specialist.
Hypersensitivity to the components of the drug
Acute and Chronic Nephritis
Heart failure in decompensation stage
Acute inflammatory skin diseases
Children’s age up to 7 years
With care: liver cirrhosis, viral hepatitis, nephritis, renal failure, advanced age.
Interaction with other drugs and alcohol:
If you are taking any other drugs, be sure to inform your doctor!
Estrogens increase the risk of developing hypervitaminosis A.
Retinol acetate reduces the anti-inflammatory effect of glucocorticoids.
Retinol acetate can not be taken at the same time with nitrates and cholestyramide, as they interfere with the absorption of the drug.
Retinol acetate should not be used with other derivatives of vitamin A because of the danger of overdose, the development of hypervitaminosis A.
The combination with vitamin E contributes to the preservation of retinol acetate in an active form, absorption from the intestine and anabolic effects.
The simultaneous use of vaseline oil may interfere with the absorption of vitamin in the intestine.
The simultaneous intake of vitamin A and anticoagulants increases the tendency to bleed. Isotretinoin increases the risk of toxic effects while taking.
Composition and properties:
Active ingredient: retinol acetate (vitamin A acetate);
1 ml of the drug contains retinol acetate (vitamin A-acetate), in terms of 100% retinol acetate – 34.4 mg (100 OOO ME);
excipient: refined deodorized sunflower oil of “P” brand, frozen out.
On 10 ml of 3,44% solution in bottles from glass melt; on 1 bottle in a pack from a cardboard.
Vitamin A (retinol) belongs to the group of fat-soluble vitamins. Retinol acetate is an analogue of natural vitamin A and is necessary to restore the normal concentration of retinol in the body. Vitamin A plays an important role in the synthesis of proteins, lipids, mucopolysaccharides, regulates the balance of minerals.
The most specific function of vitamin A is to ensure the processes of vision (photoreception). Retinol is involved in the synthesis of visual purpura – rhodopsin, located in the rods of the retina.
Vitamin A modulates the processes of differentiation of epithelial cells, is involved in the development of secretory glands, keratinization processes, regeneration of mucous membranes and skin.
Vitamin A is necessary for the normal functioning of the endocrine glands and the growth of the body, because it is a synergist of somatomedins.
Vitamin A affects the division of immunocompetent cells, the synthesis of specific factors (immunoglobulin) and nonspecific (interferon, lysozyme) protecting the body from infectious and other diseases, stimulates myelopoiesis.
Retinol increases the level of glycogen in the liver, stimulates the production of trypsin and lipase in the digestive system; inhibits photochemical free radical reactions and cysteine oxidation; activates the inclusion of sulfates in the components of connective tissue, cartilage, bones; satisfies the need for sulfocerebroside and myelin, ensuring the conduction and transmission of nerve impulses.
With a lack of vitamin A develop disorders of twilight vision (night blindness) and atrophy of the epithelium of the conjunctiva, cornea, lacrimal gland. Observed degenerative-dystrophic processes in the airways (mucosa of the nasopharynx, the paranasal sinuses, trachea, bronchi), genitourinary tract (epithelium of the renal pelvis, ureter, bladder, urethra, vagina, the ovaries, the fallopian tubes and endometrium, seminal vesicles and cords, prostate gland), in the digestive system (mucous membrane of the digestive tract, salivary glands, pancreas). Vitamin A deficiency leads to a violation of the skin trophism (hyperkeratosis), deterioration of the growth and quality of hair and nails, as well as the function of the sebaceous and sweat glands. In addition, there is a decrease in body weight and slower bone growth, a decrease in the synthesis of glucocorticoids and steroid hormones, a violation of the body’s resistance to infectious and other diseases. There is a tendency to chole-and nephrolithiasis.
A deficiency or excess of vitamin A in a woman’s body can lead to fetal abnormalities.
Retinol has an antitumor effect that does not apply to non-epithelial tumors.
Store in original packaging in the refrigerator (at a temperature of + 2 ° C to + 8 ° C).
Do not use the drug after the expiration date indicated on the package. Keep out of the reach of children.