COMPOSITION AND FORM OF ISSUE
Tetramisole is a racemic mixture of the right- and left-handed isomer. In appearance, it is a homogeneous water-soluble fine granules of white color. About 150 g is packaged in packages of laminated foil.
The active ingredient of the drug is tetramisole, a broad-spectrum nematodesocide. Tetramisole is active against mature and immature forms of gastrointestinal nematodes: Ascaris suum, Ostertagia spp., Haemonchus spp., Trychostrongylus spp., Chabertia ochina, Cooperia spp., Nematodirus spp., Bunostomum spp. Trichocephalus spp., Pulmonary nematodes: Dictyocaulus spp., Müllerius capillaries, Metastrongylus spp. The mechanism of action of the drug is to enhance cholinomimetic activity of ganglia in the nervous system of the parasite, blocking the enzymes fumarate and succinate reductase, which leads to paralysis and death of nematodes. After oral administration, tetramisole is rapidly absorbed from the gastrointestinal tract, the therapeutic concentration of the drug is reached in organs and tissues after 1 hour and is stored in the body for at least 24 hours. Tetramisole is eliminated from the body mainly through urine, partly from feces. The drug according to the degree of impact on the organism of warm-blooded animals belongs to moderately hazardous substances and in recommended doses does not have a local irritant, resorptive-toxic and sensitizing action.
Assign for the prevention and treatment of nematodoses of cattle and small ruminants, pigs.
DOSES AND METHODS OF APPLICATION
The drug is prescribed without prior starvation and laxatives, once, orally, individually or as a group in the morning in a mixture with feed or water for drinking. To large and small horned livestock, the drug is drunk from a bottle or using a probe in a dose of