Fluoxetine is a drug from the group of antidepressants that is available in capsule form for internal use. The active ingredient is fluoxetine hydrochloride.
The drug is a derivative of propylamine. Pharmacological action is the partial suppression of serotonin reuptake. As a result, there is an increase in the concentration of the drug in the synaptic cleft and enhancement of its action.
The active substance of the drug eliminates anhedonia, reduces tension, anxiety and feelings of fear. Fluoxetine does not have a toxic effect on the human body and does not provoke the appearance of orthostatic hypotension.
The development of a depressive state is due to the low serotonin content in the synaptic cleft (space in the area of neural contacts). Fluoxetine has little effect on the capture of catecholamines (adrenal medulla hormones). These include adrenaline and norepinephrine.
A special feature of the drug is that it does not affect the state of the receptors themselves. Fluoxetine may cause weight loss. The drug does not affect the heart and does not lead to drowsiness. The therapeutic effect is most pronounced in 7-14 days after the start of treatment.
Fluoxetine is an antidepressant and is used to treat depression, of various origins, obsessive-compulsive disorder (obsessive-compulsive states), and bulimia.
Indications for use
What helps Fluoxetine? The drug is effective in the following disorders:
- depression, accompanied by fears;
- bulimia, in this case, the tool is used as a component of complex psychotherapy;
- obsessive compulsive disorder;
- premenstrual dysphoria;
- prolonged alcoholism;
- bipolar disorder;
- schizophrenia and psychosis;
- obsessive states;
- resistant depression.
The drug eliminates the phenomenon of anhedonia, reduces anxiety, reduces the feeling of fear and tension. It has no toxic effect on the heart, does not cause orthostatic hypotension and sedation.
Instructions for use Fluoxetine and dosage
In case of depression, it is recommended to take Fluoxetine 20 mg daily in the morning, with insufficient effectiveness, it is possible to increase the dose to 40 mg per day (2 tablets Fluoxetine).
The maximum permissible daily dose is 80 mg in 2-3 doses, for elderly patients 60 mg (3 tablets) in 2-3 doses.
With bulimia, the recommended dose is 60 mg (3 tablets), with obsessive 20-60 mg (1-3 tablets).
The course of treatment is determined by the doctor depending on the severity of the condition. The standard duration of treatment is 4-5 weeks, after which the dose is gradually reduced to complete withdrawal within 1 week.
Fluoxetine is used with caution in elderly patients, in diseases of the circulatory system, kidney and / or liver failure. Careful control of patients who have suicidal tendencies, especially at the beginning of therapy, is necessary.
The highest probability of suicide is in patients who have previously taken other antidepressants, and in patients who have hypersomnia, excessive fatigue or motor restlessness during fluoxetine therapy.
When prescribing fluoxetine, the following side effects may occur:
- Blurred vision;
- Diarrhea, abnormal stools, nausea;
- Flushing, flutter;
- Frequent urination and ejaculatory disorders;
- Increased sweating, pruritus, skin rash and urticaria;
- Sleep disturbances, strange dreams;
- Headache, attention disorders, tremor, dizziness;
- Perhaps the development of hypomania or mania, increased suicidal tendencies, anxiety, increased irritability, agitation, seizures.
The described reactions were observed at the beginning of the capsules or with increasing doses of Fluoxetine. The development of any adverse reactions should be immediately reported to the doctor.
Hypersensitivity to fluoxetine or to any other components of the drug.
Severe liver and kidney failure, epilepsy, history of convulsions, suicidal thoughts, glaucoma, atony of the bladder, benign prostatic hyperplasia.
Simultaneous use with MAO inhibitors. The interval between the end of therapy with MAO inhibitors and the start of treatment with fluoxetine should be at least 14 days. The gap between the end of treatment with fluoxetine and the start of treatment with MAO inhibitors should be at least 5 weeks.
- Parkinson’s disease or disease;
- Diabetes or severe exhaustion;
- Liver or kidney failure in the compensation stage.
When fluoxetine is used during electroconvulsive therapy, epileptic seizures may develop.
Fluoxetine can be administered no earlier than 2 weeks after discontinuation of MAO inhibitors. After discontinuation of the drug prior to treatment with MAO inhibitors, at least 5 weeks should pass.
During drug treatment, one should refrain from drinking alcohol and engaging in potentially hazardous activities.
Compatibility with other drugs
With simultaneous use of fluoxetine with other drugs, the development of adverse drug interactions of varying degrees of severity is possible.
For this reason, it is recommended to avoid use with other antidepressants, lithium, benzodiazepine, carbamazepine, haloperidol, warfarin.
Fluoxetine Analogues, Drug List
If necessary, you can replace Fluoxetine with an ATH code analogue, a list of drugs:
Choosing analogues it is important to understand that the instructions for use of Fluoxetine, the price and reviews of drugs of similar action do not apply. It is important to consult a doctor and not to make an independent replacement of the drug.
The price in pharmacies is about 50 rubles per pack.
Store in a dry, dark place at a temperature not exceeding 25 ° C. Keep out of the reach of children. Shelf life – 3 years.